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GENE：VAV2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VAV2
FullNmae vav guanine nucleotide exchange factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12658
EnsembleID ENSG00000160293
Uniprot P52735

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VAV2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
VAV2 GO:0001525,GO:0001784,GO:0005085,GO:0005085,GO:0005085,GO:0005154,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007264,GO:0008361,GO:0016477,GO:0030032,GO:0030168,GO:0038095,GO:0038096,GO:0043087,GO:0043087,GO:0046872,GO:0048010,GO:0051056,GO:0071466

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VAV2 hsa:7410 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04510 Focal adhesion - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
VAV2 hsa:7410 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
VAV2 hsa:7410 path:hsa05135 Yersinia infection - Homo sapiens (human)
VAV2 hsa:7410 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
VAV2 hsa:7410 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR VAV2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 VAV2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 VAV2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 VAV2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 VAV2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 VAV2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C VAV2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 VAV2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 VAV2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000070B1D VAV2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 VAV2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD VAV2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003BBF48 VAV2 21703006 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000209F04 VAV2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B VAV2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001597DC VAV2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 VAV2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 VAV2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C VAV2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D VAV2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 VAV2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A VAV2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 VAV2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EGFR VAV2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ARHGDIA VAV2 25361965 interaction type N/A PTMCode2
VAV2 ARHGDIA 25361965 interaction type N/A PTMCode2
CBL VAV2 25361965 interaction type N/A PTMCode2
VAV2 CBL 25361965 interaction type N/A PTMCode2
LCP2 VAV2 25361965 interaction type N/A PTMCode2
VAV2 LCP2 25361965 interaction type N/A PTMCode2
RAC1 VAV2 25361965 interaction type N/A PTMCode2
VAV2 RAC1 25361965 interaction type N/A PTMCode2
VAV2 EGFR 25361965 interaction type N/A PTMCode2
GRB2 VAV2 25361965 interaction type N/A PTMCode2
VAV2 GRB2 25361965 interaction type N/A PTMCode2
VAV2 SYK 25361965 interaction type N/A PTMCode2
SYK VAV2 25361965 interaction type N/A PTMCode2
VAV2 PRLR 25361965 interaction type N/A PTMCode2
PRLR VAV2 25361965 interaction type N/A PTMCode2
ERBB4 VAV2 25361965 interaction type N/A PTMCode2
VAV2 ERBB4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SF3A3 VAV2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNW1 VAV2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TPD52L2 VAV2 25348397 N/A physical interaction ComPPI
PRKAR2B VAV2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRGBP VAV2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MED21 VAV2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RAC1 VAV2 14525934 16397238 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PNMA1 VAV2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CD44 VAV2 11606575 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ERBB2 VAV2 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
TXNIP VAV2 24234451 25348397 26919541 N/A isothermal titration calorimetry,x-ray crystallography ComPPI,IntAct
CBL VAV2 11313921 14525934 15345594 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
PRLR VAV2 14525934 15618286 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
RHOG VAV2 11909943 12376551 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SYK VAV2 14525934 15345594 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SH3BP2 VAV2 11390470 14525934 15345594 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,in vivo ComPPI,HPRD,IntAct
SOCS1 VAV2 10022833 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NEK3 VAV2 14525934 15618286 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,IntAct
CBLB VAV2 25348397 N/A physical interaction ComPPI
VAV2 GRB2 11606575 12577067 14525934 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
VAV2 EPHB2 14525934 15848800 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VAV2 EGFR 10618391 10938113 11516622 12454019 14525934 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
VAV2 CD19 11080163 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
VAV2 PDGFRB 25348397 N/A physical interaction ComPPI
VAV2 CCNO 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 BRDT 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 EIF4G3 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 RBBP6 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 ST13 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 ST13P4 25348397 N/A physical interaction ComPPI
VAV2 TOM1L1 18654987 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
VAV2 VCPIP1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 BOD1L1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 SRRT 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 FNTA 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 TCP11 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 MARCHF7 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 HSPH1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 BZW1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 SERBP1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 USP38 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 UBE4B 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 GAPVD1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 POGZ 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 TARBP2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 IPO4 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 FUCA1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 CHMP3 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 NCKAP5 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 CEP170 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 RAD23A 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 DNAJC21 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 TTN 18654987 23414517 24234451 25348397 physical association two hybrid,physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
VAV2 CCT3 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 DCUN1D4 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 STK24 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 PHF10 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 PPM1B 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 ARIH1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 BIRC6 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 SRPK2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 CCT2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 CRCP 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 ELAVL1 25348397 N/A physical interaction ComPPI
VAV2 FYN 25348397 N/A physical interaction ComPPI
VAV2 SMAD3 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
VAV2 THOP1 25348397 N/A physical interaction ComPPI
VAV2 ERBB3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
VAV2 CAV1 20808760 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,protein array,pull down,physical interaction ComPPI,IntAct
VAV2 NTRK1 25348397 N/A physical interaction ComPPI
VAV2 RTEL1 25348397 N/A physical interaction ComPPI
VAV2 TRIM25 25348397 N/A physical interaction ComPPI
VAV2 HNRNPL 25348397 N/A physical interaction ComPPI
VAV2 ABI1 20598684 24234451 25348397 N/A array technology ComPPI,IntAct
VAV2 AR 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
VAV2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
VAV2 SF1 24234451 25348397 26420826 physical association two hybrid fragment pooling approach ComPPI,IntAct
RHOA VAV2 11909943 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GAB1 VAV2 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
HNRNPF VAV2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VAV2 VAV2 12376551 14525934 N/A experimental interaction detection HPRD
SRC VAV2 1311423 1531699 27898060 stimulant N/A OmniPath
LCK VAV2 12400014 12454019 27898060 stimulant N/A OmniPath
EGFR VAV2 10618391 10938113 11516622 12454019 17016520 17389395 18271526 19531499 20940296 24797263 27898060 stimulant N/A OmniPath
VAV2 EGFR 10618391 10938113 11516622 12454019 18271526 19531499 20940296 24797263 27898060 stimulant N/A OmniPath
IGF1R VAV2 11094073 27898060 stimulant N/A OmniPath
CTNND1 VAV2 22946057 27898060 stimulant N/A OmniPath
VAV2 RAC1 10982832 11790798 16397238 27898060 8990121 stimulant N/A OmniPath
GRB2 VAV2 11606575 12577067 27898060 7809090 stimulant N/A OmniPath
ABL1 VAV2 11790798 27898060 stimulant N/A OmniPath
SH2B2 VAV2 12400014 27898060 stimulant N/A OmniPath
VAV2 CDC42 27898060 8994827 9032261 stimulant N/A OmniPath
SIAH2 VAV2 10207103 27898060 inhibition N/A OmniPath
SMAD3 VAV2 18729074 27898060 N/A N/A OmniPath
ZAP70 VAV2 27898060 7798261 stimulant N/A OmniPath
CBLB VAV2 12881521 27898060 inhibition N/A OmniPath
VAV2 ARHGAP1 27898060 8994827 9032261 9822605 stimulant N/A OmniPath

Visualization










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