GENE：CR1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CR1 |
| FullNmae | complement C3b/C4b receptor 1 (Knops blood group) |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2334 |
| EnsembleID | ENSG00000203710 |
| Uniprot | P17927 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CR1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CR1 | GO:0001618,GO:0001851,GO:0001855,GO:0001861,GO:0001970,GO:0001971,GO:0002430,GO:0002435,GO:0002456,GO:0002638,GO:0004877,GO:0005515,GO:0005615,GO:0005856,GO:0005886,GO:0005886,GO:0005886,GO:0006957,GO:0006958,GO:0007009,GO:0008284,GO:0009986,GO:0030667,GO:0032689,GO:0032703,GO:0042130,GO:0044853,GO:0045591,GO:0045916,GO:0045957,GO:0045959,GO:0045959,GO:0046718,GO:0070062,GO:0101003,GO:1900004,GO:1900005,GO:1900099,GO:1903660,GO:1904669 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CR1 | hsa:1378 | path:hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| CR1 | hsa:1378 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| CR1 | hsa:1378 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| CR1 | hsa:1378 | path:hsa05134 | Legionellosis - Homo sapiens (human) |
| CR1 | hsa:1378 | path:hsa05140 | Leishmaniasis - Homo sapiens (human) |
| CR1 | hsa:1378 | path:hsa05144 | Malaria - Homo sapiens (human) |
| CR1 | hsa:1378 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMARCA4 | CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | CR1 | 10533284 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| C4A | CR1 | 14525934 25348397 27898060 8422437 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| C3 | CR1 | 10382758 14525934 25348397 9988761 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| C1QA | CR1 | 10528211 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CR2 | CR1 | 14525934 1708808 25348397 27898060 7690834 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| CR1 | FUT4 | 14525934 25348397 3305706 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CD55 | CR1 | 11694537 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |