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GENE：CDC45

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDC45
FullNmae cell division cycle 45
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1739
EnsembleID ENSG00000093009
Uniprot O75419

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDC45 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDC45 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDC45 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CDC45 GO:0000076,GO:0000727,GO:0003682,GO:0003688,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005813,GO:0006268,GO:0006270,GO:0031261,GO:0036064,GO:0071162,GO:1902977

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDC45 hsa:8318 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDC45 CDC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
CDC45 MCM5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
CDC45 ORC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
CDT1 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM2 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM3 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM4 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM6 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM7 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC1 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC3 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
CDK2 CDC45 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 CDC45 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 CDC45 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
RPA1 CDC45 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA2 CDC45 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA3 CDC45 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
HUS1 CDC45 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD1 CDC45 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD17 CDC45 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
CDK1 CDC45 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 26192618 7575488 interaction type N/A ACSN
ATRIP CDC45 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
ATR CDC45 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CHEK1 CDC45 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CLSPN CDC45 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
TIPIN CDC45 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR CDC45 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA3 CDC45 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CDC45 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CDC45 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CDC45 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CDC45 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CDC45 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 CDC45 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CDC45 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CDC45 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CDC45 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CDC45 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 CDC45 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F3 CDC45 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AD002 CDC45 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
ORC1 CDC45 25348397 N/A physical interaction ComPPI
CIAO1 CDC45 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PCNA CDC45 25348397 N/A physical interaction ComPPI
CDKN1A CDC45 14525934 15232106 24234451 25241761 25348397 physical association experimental interaction detection,protein array,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
MCM6 CDC45 19805216 24234451 25348397 N/A physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
MCM2 CDC45 19805216 24234451 25348397 26167883 association anti tag coimmunoprecipitation,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
ORC6 CDC45 25348397 N/A physical interaction ComPPI
DDIT4L CDC45 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPP4C CDC45 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
POLA1 CDC45 10518787 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CUL3 CDC45 25348397 N/A physical interaction ComPPI
MCM10 CDC45 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CDKN2A CDC45 15232106 24234451 25348397 N/A protein array,physical interaction,in vitro ComPPI,IntAct
UBC CDC45 25348397 N/A physical interaction ComPPI
NTRK1 CDC45 25348397 N/A physical interaction ComPPI
SQSTM1 CDC45 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
BRCA2 CDC45 22293751 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA2 CDC45 23910567 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
ORC2 CDC45 14525934 25348397 9660782 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ACTR1A CDC45 25348397 N/A physical interaction ComPPI
CEP55 CDC45 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDK2 CDC45 25348397 N/A physical interaction ComPPI
POLD1 CDC45 23910567 24234451 25348397 association pull down ComPPI,IntAct
H3C1 CDC45 25348397 N/A physical interaction ComPPI
CDC45 MCM3 25348397 N/A two hybrid,physical interaction ComPPI
CDC45 ORC3 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CDC45 ORC5 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CDC45 CDK4 14525934 15232106 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDC45 MCM7 10518787 12614612 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CDC45 MCM4 25348397 N/A physical interaction ComPPI
CDC45 CCL2 25348397 N/A physical interaction ComPPI
CDC45 L3MBTL1 21149733 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC45 ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC45 CDKN2A 25348397 N/A physical interaction ComPPI
CDC45 DTD1 25348397 N/A physical interaction ComPPI
CDC45 TOPBP1 17887956 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CDC45 CAMK1G 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDC45 TRAPPC3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDC45 FBXO6 25348397 N/A physical interaction ComPPI
CDC45 PDS5B 22293751 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC45 RPS6KB2 25348397 N/A physical interaction ComPPI
CDC45 RFC1 25348397 N/A physical interaction ComPPI
CDC45 AAR2 25348397 N/A physical interaction ComPPI
CDC45 GINS4 19805216 24234451 25348397 N/A physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
CDC45 TSC22D1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDC45 CLSPN 23910567 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
CDC45 ZRANB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC45 CDC23 12972571 22433840 27898060 N/A N/A OmniPath
CDC45 MRC1 12944972 19515819 19819872 19913425 27898060 N/A N/A OmniPath
TOPBP1 CDC45 17887956 27898060 stimulant N/A OmniPath

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