Gene Information gene info

GENE:CXCL6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CXCL6
FullNmae C-X-C motif chemokine ligand 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10643
EnsembleID ENSG00000124875
Uniprot P80162

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CXCL6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CXCL6 GO:0001776,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007165,GO:0007267,GO:0008009,GO:0008009,GO:0008201,GO:0030593,GO:0030593,GO:0032642,GO:0042119,GO:0042742,GO:0045236,GO:0061844,GO:0061844,GO:0070098,GO:0070951,GO:0071222,GO:0071222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CXCL6 hsa:6372 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
CXCL6 hsa:6372 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
CXCL6 hsa:6372 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
CXCL6 hsa:6372 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
CXCL6 hsa:6372 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
CXCL6 hsa:6372 path:hsa05133 Pertussis - Homo sapiens (human)
CXCL6 hsa:6372 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CXCL6 MMP1 18660381 23180781 protein cleavage protease assay InnateDB
CXCL6 MMP9 18660381 23180781 protein cleavage protease assay InnateDB
CXCL6 CXCR1 23180781 9485196 physical association competition binding InnateDB
CXCL6 CXCR2 23180781 9485196 physical association competition binding InnateDB
MMP12 CXCL6 18660381 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR CXCL6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 CXCL6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CXCL6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CXCL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CXCL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CXCL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CXCL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 CXCL6 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000821E0 CXCL6 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CXCL6 CXCR1 25361965 interaction type N/A PTMCode2
CXCR1 CXCL6 25361965 interaction type N/A PTMCode2
CXCL6 MMP9 25361965 interaction type N/A PTMCode2
MMP9 CXCL6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PF4 CXCL6 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CCL5 CXCL6 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CXCR2 CXCL6 10593335 14525934 25348397 9692902 N/A experimental interaction detection,in vivo ComPPI,HPRD
CCL8 CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL12 CXCL6 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
SSX2IP CXCL6 24234451 24397932 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CCL11 CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL1 CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
MMP9 CXCL6 25348397 N/A physical interaction ComPPI
PPBP CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CCL7 CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCR1 CXCL6 10593335 14525934 25348397 9692902 N/A experimental interaction detection,in vivo ComPPI,HPRD
CXCL10 CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL6 CXCL3 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL2 CXCL6 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
MMP9 CXCL6 18660381 27898060 N/A N/A OmniPath
MMP1 CXCL6 18660381 27898060 N/A N/A OmniPath
CXCL6 CXCR2 10593335 24218476 27898060 9485196 9692902 stimulant N/A OmniPath
CXCL6 CXCR1 10593335 12964882 24218476 27898060 9485196 9692902 stimulant N/A OmniPath

Visualization