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GENE：INPP5D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol INPP5D
FullNmae inositol polyphosphate-5-phosphatase D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6079
EnsembleID ENSG00000168918
Uniprot Q92835

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
INPP5D immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
INPP5D GO:0004439,GO:0004445,GO:0005515,GO:0005829,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0006661,GO:0006796,GO:0006915,GO:0007165,GO:0008340,GO:0009968,GO:0016064,GO:0016314,GO:0017124,GO:0030889,GO:0032715,GO:0034485,GO:0035556,GO:0043065,GO:0045121,GO:0045579,GO:0045648,GO:0045656,GO:0045659,GO:0045671,GO:0045779,GO:0046856,GO:0050776,GO:0050777,GO:0050852,GO:0052658,GO:0052659

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
INPP5D hsa:3635 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
INPP5D hsa:3635 path:hsa01100 Metabolic pathways - Homo sapiens (human)
INPP5D hsa:3635 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
INPP5D hsa:3635 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
INPP5D hsa:3635 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
INPP5D hsa:3635 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIK3R1 INPP5D 23180781 9918857 physical association anti tag coimmunoprecipitation InnateDB
FLT3 INPP5D 23180781 9918857 physical association anti tag coimmunoprecipitation InnateDB
INPP5D LYN 12882960 23180781 physical association affinity technology InnateDB
XIAP INPP5D 22815893 23180781 physical association anti tag coimmunoprecipitation InnateDB
INPP5D CDKN1A 19322021 23180781 physical association anti tag coimmunoprecipitation InnateDB
TIGIT INPP5D 23180781 24817116 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 INPP5D 23180781 24817116 physical association anti tag coimmunoprecipitation InnateDB
SHC1 INPP5D 10207047 10822173 23331499 8643691 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
DOK1 INPP5D 10822173 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
DOK2 INPP5D 10822173 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
DOK3 INPP5D 20005715 interaction type N/A PSP
GRB2 INPP5D 20005715 interaction type N/A PSP
PIK3R1 INPP5D 20005715 interaction type N/A PSP,SignaLink
SHC1 INPP5D 20005715 interaction type N/A PSP,SignaLink
GRB2 INPP5D 20005715 N/A N/A SignaLink
DOK3 INPP5D 10733577 14993273 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 INPP5D 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 INPP5D 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 INPP5D 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 INPP5D 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 INPP5D 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 INPP5D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA INPP5D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF INPP5D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 INPP5D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS INPP5D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A INPP5D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 INPP5D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 INPP5D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR INPP5D 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 INPP5D 19359473 19641183 19890474 20041145 \N rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000338542 INPP5D 19359473 19641183 19890474 20041145 22982040 24522920 25416803 25971362 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 INPP5D 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000DDD35 INPP5D 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
UBASH3B INPP5D 25348397 N/A physical interaction ComPPI
SH3KBP1 INPP5D 15090612 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KRTAP10-7 INPP5D 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
XIAP INPP5D 25348397 N/A physical interaction ComPPI
KRT31 INPP5D 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRT40 INPP5D 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DAB2 INPP5D 25348397 N/A physical interaction ComPPI
CBL INPP5D 16601135 25348397 27898060 9393882 N/A physical interaction ComPPI,OmniPath
SYK INPP5D 25348397 N/A physical interaction ComPPI
PECAM1 INPP5D 25348397 N/A physical interaction,in vitro ComPPI
CD2AP INPP5D 25348397 N/A physical interaction ComPPI
KIT INPP5D 11071635 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LYN INPP5D 12882960 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIK3R1 INPP5D 25348397 N/A physical interaction ComPPI
PTPN11 INPP5D 14525934 25348397 9110989 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CRKL INPP5D 11443118 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DOK1 INPP5D 10822173 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SLAMF1 INPP5D 11313386 24234451 25348397 association coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
INPP5D GRB2 10900203 14525934 25348397 8723348 9108392 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
INPP5D SHC1 10704825 12024011 14525934 24234451 25348397 8643691 8723348 8874179 N/A experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
INPP5D LILRB4 25348397 N/A in vitro ComPPI
INPP5D DOK3 10733577 14525934 14993273 17290227 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
INPP5D CD300LF 14525934 15184070 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
INPP5D DOK2 10822173 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
INPP5D CSF1R 14525934 15735664 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
INPP5D MET 14525934 15735664 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
INPP5D FLT3 14525934 25348397 9918857 N/A experimental interaction detection,in vivo ComPPI,HPRD
INPP5D CD22 10748054 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
INPP5D EPOR 10660611 14525934 15644415 24234451 25348397 association,physical association two hybrid,experimental interaction detection,pull down,physical interaction,mammalian protein protein interaction trap,in vivo,two hybrid ComPPI,HPRD,IntAct
INPP5D CSF3R 14525934 15470047 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
INPP5D JAK1 10875931 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
INPP5D JAK3 10875931 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
INPP5D GAB2 11402314 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
INPP5D FCGR2B 10382761 14525934 24234451 24642916 25348397 9148918 association,physical association affinity chromatography technology,experimental interaction detection,pull down,surface plasmon resonance,in vitro ComPPI,HPRD,IntAct
INPP5D HCK 12029088 14525934 24234451 25348397 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
INPP5D IL4R 11714803 14525934 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
INPP5D PRKCD 25348397 N/A physical interaction ComPPI
INPP5D TRIP10 25348397 N/A physical interaction ComPPI
INPP5D BCR 25348397 N/A physical interaction ComPPI
INPP5D MME 17342744 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
INPP5D ARAP1 25348397 N/A physical interaction ComPPI
INPP5D NCK1 25348397 N/A physical interaction ComPPI
INPP5D LRRK1 25348397 N/A physical interaction ComPPI
INPP5D INPPL1 25348397 N/A physical interaction ComPPI
INPP5D DAB1 25348397 N/A physical interaction ComPPI
INPP5D KHDRBS3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
INPP5D KRTAP10-9 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
INPP5D KRTAP10-3 25348397 N/A physical interaction ComPPI
INPP5D NOTCH2NLA 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
INPP5D ZDHHC17 25348397 N/A physical interaction ComPPI
INPP5D FAS 11786908 24234451 25348397 association pull down ComPPI,IntAct
INPP5D TNFRSF1A 11786908 24234451 25348397 association pull down ComPPI,IntAct
INPP5D SH2D1B 23322602 24234451 25348397 association pull down ComPPI,IntAct
INPP5D LY9 24234451 25348397 26221972 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
INPP5D CD244 24234451 24642916 25348397 26221972 association pull down,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
INPP5D SIRPA 24234451 24642916 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
GAB1 INPP5D 11402314 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
INPP5D FGR 10229804 14525934 N/A experimental interaction detection HPRD
INPP5D INPP5D 14525934 9422771 N/A experimental interaction detection HPRD
PLCG1 INPP5D 14525934 15953601 N/A experimental interaction detection HPRD
HMGA1 INPP5D 24234451 30021884 physical association cross-linking study IntAct
CDKN1A INPP5D 19322021 27898060 N/A N/A OmniPath
INPP5D LYN 12882960 27898060 N/A N/A OmniPath
TRAF6 INPP5D 24817116 27898060 N/A N/A OmniPath
SHC1 INPP5D 10194451 10207047 10704825 10822173 10900203 11970986 12008030 12024011 15470047 20697350 27898060 8643691 8723348 8874179 9083021 9099679 9393882 stimulant N/A OmniPath
PIK3R1 INPP5D 27898060 9918857 N/A N/A OmniPath
INPP5D PIK3R1 27898060 9918857 N/A N/A OmniPath

Visualization










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