GENE:NIPBL
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NIPBL |
| FullNmae | NIPBL cohesin loading factor |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:28862 |
| EnsembleID | ENSG00000164190 |
| Uniprot | Q6KC79 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NIPBL | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NIPBL | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NIPBL | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NIPBL | GO:0000070,GO:0000122,GO:0000785,GO:0001656,GO:0003007,GO:0003007,GO:0003151,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0006338,GO:0006974,GO:0007064,GO:0007064,GO:0007420,GO:0007420,GO:0007605,GO:0008104,GO:0032039,GO:0032116,GO:0034087,GO:0034088,GO:0035019,GO:0035115,GO:0035136,GO:0035261,GO:0036033,GO:0040018,GO:0042471,GO:0042634,GO:0042826,GO:0043231,GO:0045444,GO:0045778,GO:0045944,GO:0045995,GO:0048557,GO:0048565,GO:0048589,GO:0048592,GO:0048638,GO:0048703,GO:0050890,GO:0060325,GO:0061010,GO:0061038,GO:0061775,GO:0061780,GO:0070062,GO:0070087,GO:0071169,GO:0071481,GO:0090694,GO:0090694,GO:1990414,GO:1990841,GO:2001224 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NIPBL | hsa:25836 | path:hsa04110 | Cell cycle - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | NIPBL | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | NIPBL | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | NIPBL | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | NIPBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NIPBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NIPBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NIPBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | NIPBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NIPBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NIPBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NIPBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | NIPBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000055128B | NIPBL | 19826008 25416803 | mrna cleavage,inhibition | array technology,rna immunoprecipitation,quantitative reverse transcription pcr | TarBase |
| URS00004505E4 | NIPBL | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS000009262D | NIPBL | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000324096 | NIPBL | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS000035CC3E | NIPBL | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002152A8 | NIPBL | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000345DEB | NIPBL | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000204177 | NIPBL | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A71AD | NIPBL | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058DCD8 | NIPBL | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | NIPBL | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000259AE4 | NIPBL | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SNW1 | NIPBL | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDC5L | NIPBL | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDK6 | NIPBL | 22094256 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
| RAD21 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| RPL10 | NIPBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SF3A2 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| RPA1 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| KSR2 | NIPBL | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| EWSR1 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| RPA2 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| RPA3 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| SP100 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| SMC1A | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| CBX5 | NIPBL | 20562864 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| MED23 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| SMC3 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| EED | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| CDK8 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| TFG | NIPBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ARFGAP1 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| BRCA1 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| HINFP | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| LDHD | NIPBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TOMM40 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| PRSS23 | NIPBL | 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| MLLT3 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| USP37 | NIPBL | 25348397 | N/A | physical interaction | ComPPI |
| DBN1 | NIPBL | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| NIPBL | CBX3 | 25348397 | N/A | physical interaction | ComPPI |
| NIPBL | SIRT7 | 25348397 | N/A | physical interaction | ComPPI |
| NIPBL | PPT1 | 25348397 | N/A | physical interaction | ComPPI |
| NIPBL | MAU2 | 16802858 21934712 24234451 25348397 26496610 | association,physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| NIPBL | OBSL1 | 25348397 | N/A | physical interaction | ComPPI |
| NIPBL | CCDC8 | 25348397 | N/A | physical interaction | ComPPI |
| NIPBL | SUCO | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MKI67 | NIPBL | 24234451 26949251 | association | anti tag coimmunoprecipitation | IntAct |
