Gene Information gene info

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GENE：ATG2B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATG2B
FullNmae autophagy related 2B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20187
EnsembleID ENSG00000066739
Uniprot Q96BY7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATG2B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATG2B autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATG2B autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ATG2B GO:0000045,GO:0000407,GO:0000422,GO:0005789,GO:0005811,GO:0032266,GO:0034045,GO:0034727,GO:0044805,GO:0061709,GO:0120009,GO:0120013

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATG2B hsa:55102 path:hsa04136 Autophagy - other - Homo sapiens (human)
ATG2B hsa:55102 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ATG2B hsa:55102 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ATG2B hsa:55102 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
ATG2B hsa:55102 path:hsa05016 Huntington disease - Homo sapiens (human)
ATG2B hsa:55102 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ATG2B hsa:55102 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 ATG2B 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ATG2B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A ATG2B 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 ATG2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATG2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATG2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATG2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000315338 ATG2B 22350415 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000315338 ATG2B 22350415 22743998 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00004505E4 ATG2B 20371350 21572407 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000005CF5F ATG2B 23274497 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000042E1F ATG2B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 ATG2B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A ATG2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F ATG2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008931A ATG2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 ATG2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 ATG2B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 ATG2B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 ATG2B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ATG2B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ATG2B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ATG2B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 ATG2B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000032FC1A ATG2B 25416803 26771516 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MCM6 ATG2B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MCM2 ATG2B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AP1G2 ATG2B 25348397 N/A physical interaction ComPPI
SLAMF1 ATG2B 25348397 N/A physical interaction ComPPI
GSK3B ATG2B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NTRK1 ATG2B 25348397 N/A physical interaction ComPPI
SKP2 ATG2B 25348397 N/A physical interaction ComPPI
SPAG9 ATG2B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MCM4 ATG2B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MED4 ATG2B 25348397 N/A physical interaction ComPPI
SALL2 ATG2B 25348397 N/A physical interaction ComPPI
DUSP26 ATG2B 25348397 N/A physical interaction ComPPI
TKT ATG2B 25348397 N/A physical interaction ComPPI
MLF1 ATG2B 25348397 N/A physical interaction ComPPI
USP15 ATG2B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
WDR45 ATG2B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDIA6 ATG2B 24234451 30021884 physical association cross-linking study IntAct

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