GENE：WNT5B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | WNT5B |
| FullNmae | Wnt family member 5B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16265 |
| EnsembleID | ENSG00000111186 |
| Uniprot | Q9H1J7 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| WNT5B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| WNT5B | GO:0002062,GO:0005102,GO:0005109,GO:0005125,GO:0005576,GO:0005615,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0030182,GO:0030182,GO:0030335,GO:0030666,GO:0042692,GO:0045165,GO:0045444,GO:0060070,GO:0062023,GO:0070062,GO:0070062,GO:0070307,GO:0071300,GO:1904105,GO:2000052 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| WNT5B | hsa:81029 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| WNT5B | hsa:81029 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | WNT5B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | WNT5B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | WNT5B | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | WNT5B | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | WNT5B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| APPBP2 | WNT5B | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| WNT5A | WNT5B | 25348397 | N/A | physical interaction | ComPPI |
| PORCN | WNT5B | 10866835 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| WNT5B | LRP5 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT5B | LRP6 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT5B | FZD3 | 15578921 16273260 27898060 | stimulant | N/A | OmniPath |
| WNT5B | FZD6 | 16273260 27898060 | stimulant | N/A | OmniPath |