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GENE：DYNC1H1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DYNC1H1
FullNmae dynein cytoplasmic 1 heavy chain 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2961
EnsembleID ENSG00000197102
Uniprot Q14204

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DYNC1H1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DYNC1H1 immunogenic 36579538 Through literature reviews, a total of 108 ICD-related genes were identified (Supplement Table S1). retulator signature
DYNC1H1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DYNC1H1 GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005813,GO:0005829,GO:0005868,GO:0005868,GO:0005868,GO:0005874,GO:0005881,GO:0005938,GO:0007052,GO:0007052,GO:0007097,GO:0008090,GO:0008569,GO:0016020,GO:0016887,GO:0030175,GO:0030286,GO:0031122,GO:0032388,GO:0033962,GO:0034063,GO:0035578,GO:0045505,GO:0051293,GO:0051301,GO:0051959,GO:0060236,GO:0070062,GO:0090235,GO:0120162,GO:1904115,GO:1905832

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DYNC1H1 hsa:1778 path:hsa04145 Phagosome - Homo sapiens (human)
DYNC1H1 hsa:1778 path:hsa04814 Motor proteins - Homo sapiens (human)
DYNC1H1 hsa:1778 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)
DYNC1H1 hsa:1778 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DYNC1H1 ELP1 18303054 23180781 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 DYNC1H1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 DYNC1H1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
BMI1 DYNC1H1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 DYNC1H1 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR DYNC1H1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DYNC1H1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 DYNC1H1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 DYNC1H1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DYNC1H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC DYNC1H1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AD002 DYNC1H1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 DYNC1H1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D DYNC1H1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 DYNC1H1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016FF9C DYNC1H1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 DYNC1H1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000013E79D DYNC1H1 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F DYNC1H1 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A DYNC1H1 24374217 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DYNC1H1 DYNLRB1 25361965 interaction type N/A PTMCode2
DYNLRB1 DYNC1H1 25361965 interaction type N/A PTMCode2
DYNC1H1 DCTN1 25361965 interaction type N/A PTMCode2
DCTN1 DYNC1H1 25361965 interaction type N/A PTMCode2
DYNC1H1 DYNLT1 25361965 interaction type N/A PTMCode2
DYNLT1 DYNC1H1 25361965 interaction type N/A PTMCode2
DYNC1H1 MAPRE1 25361965 interaction type N/A PTMCode2
MAPRE1 DYNC1H1 25361965 interaction type N/A PTMCode2
DYNC1H1 DYNLT3 25361965 interaction type N/A PTMCode2
DYNLT3 DYNC1H1 25361965 interaction type N/A PTMCode2
DYNC1H1 PAFAH1B1 25361965 interaction type N/A PTMCode2
PAFAH1B1 DYNC1H1 25361965 interaction type N/A PTMCode2
NDEL1 DYNC1H1 25361965 interaction type N/A PTMCode2
DYNC1H1 NDEL1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPRE1 DYNC1H1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNRPB DYNC1H1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SNW1 DYNC1H1 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CDC5L DYNC1H1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SAP30BP DYNC1H1 25348397 N/A physical interaction ComPPI
DYNLL1 DYNC1H1 14525934 14760703 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
SNRPA1 DYNC1H1 25348397 N/A physical interaction ComPPI
TRAF6 DYNC1H1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GABARAPL2 DYNC1H1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FOXB1 DYNC1H1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAG DYNC1H1 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMI1 DYNC1H1 25348397 N/A physical interaction ComPPI
KEAP1 DYNC1H1 25348397 N/A physical interaction ComPPI
MCM2 DYNC1H1 25348397 N/A physical interaction ComPPI
MAP1LC3B DYNC1H1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
STRN DYNC1H1 25348397 N/A physical interaction ComPPI
PLOD3 DYNC1H1 25348397 N/A physical interaction ComPPI
NCOA5 DYNC1H1 25348397 N/A physical interaction ComPPI
PPP4C DYNC1H1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PRKCD DYNC1H1 25348397 N/A physical interaction ComPPI
GRB2 DYNC1H1 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
JUN DYNC1H1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD2 DYNC1H1 14525934 15231748 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
COPS5 DYNC1H1 25348397 N/A physical interaction ComPPI
USP7 DYNC1H1 25348397 N/A physical interaction ComPPI
TPM2 DYNC1H1 25348397 N/A physical interaction ComPPI
FLNC DYNC1H1 25348397 N/A physical interaction ComPPI
FLNA DYNC1H1 25348397 N/A physical interaction ComPPI
U2AF2 DYNC1H1 25348397 N/A physical interaction ComPPI
SPART DYNC1H1 19765186 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CUL3 DYNC1H1 25348397 N/A physical interaction ComPPI
DYNC1LI1 DYNC1H1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ DYNC1H1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
HSP90AA1 DYNC1H1 19875381 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NTRK1 DYNC1H1 25348397 N/A physical interaction ComPPI
YBX1 DYNC1H1 25348397 N/A physical interaction ComPPI
DYNLT3 DYNC1H1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC5 DYNC1H1 25348397 N/A physical interaction ComPPI
HSPA1A DYNC1H1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA1B DYNC1H1 25348397 N/A physical interaction ComPPI
MYC DYNC1H1 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
AKAP12 DYNC1H1 25348397 N/A physical interaction ComPPI
PRMT5 DYNC1H1 25348397 N/A physical interaction ComPPI
HNRNPL DYNC1H1 25348397 N/A physical interaction ComPPI
DCTN1 DYNC1H1 24234451 25348397 26496610 26638075 association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DUSP16 DYNC1H1 24234451 25348397 28330616 association pull down ComPPI,IntAct
CFTR DYNC1H1 25348397 N/A physical interaction ComPPI
NPHP1 DYNC1H1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RANBP9 DYNC1H1 25348397 N/A physical interaction ComPPI
PDHA1 DYNC1H1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RUFY1 DYNC1H1 25348397 N/A physical interaction ComPPI
BICD2 DYNC1H1 25348397 N/A physical interaction ComPPI
TNIK DYNC1H1 25348397 N/A physical interaction ComPPI
RPA2 DYNC1H1 25348397 N/A physical interaction ComPPI
YWHAQ DYNC1H1 25348397 N/A physical interaction ComPPI
PAFAH1B1 DYNC1H1 24234451 25348397 26496610 27173435 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
ARF6 DYNC1H1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HTATSF1 DYNC1H1 25348397 N/A physical interaction ComPPI
ARRB2 DYNC1H1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSEN2 DYNC1H1 21163940 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
ACTR1A DYNC1H1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 DYNC1H1 25348397 N/A physical interaction ComPPI
SYNCRIP DYNC1H1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR DYNC1H1 20029029 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
HTT DYNC1H1 17500595 17548833 24234451 25348397 association,physical association two hybrid,pull down,physical interaction ComPPI,IntAct
TENT5A DYNC1H1 25348397 N/A physical interaction ComPPI
PHB2 DYNC1H1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RNF2 DYNC1H1 25348397 N/A physical interaction ComPPI
SF3A1 DYNC1H1 25348397 N/A physical interaction ComPPI
HDAC6 DYNC1H1 25348397 N/A physical interaction ComPPI
MAP1LC3A DYNC1H1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SIRT1 DYNC1H1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
VCAM1 DYNC1H1 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 DYNC1H1 25348397 N/A physical interaction ComPPI
DNM1L DYNC1H1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATXN3 DYNC1H1 25348397 N/A physical interaction ComPPI
MAGED1 DYNC1H1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CUL7 DYNC1H1 25348397 N/A physical interaction ComPPI
H3C1 DYNC1H1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SRSF9 DYNC1H1 25348397 N/A physical interaction ComPPI
DYNC1H1 NDEL1 11163259 11163260 14525934 14970193 15208636 18331715 18784752 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
DYNC1H1 TSC22D1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 RAB5IF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 TOR1A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 EPB41 25348397 N/A physical interaction ComPPI
DYNC1H1 RYK 25348397 N/A physical interaction ComPPI
DYNC1H1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DYNC1H1 CSNK2B 25348397 N/A physical interaction ComPPI
DYNC1H1 SIRT7 25348397 N/A physical interaction ComPPI
DYNC1H1 KATNA1 25348397 N/A physical interaction ComPPI
DYNC1H1 KATNB1 24234451 25348397 26929214 association physical interaction,tandem affinity purification ComPPI,IntAct
DYNC1H1 LRRK2 25348397 N/A physical interaction ComPPI
DYNC1H1 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 DYNLT1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
DYNC1H1 DYNC1LI2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 MAX 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
DYNC1H1 FUS 25348397 N/A physical interaction ComPPI
DYNC1H1 DYNLRB1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 YARS1 25348397 N/A physical interaction ComPPI
DYNC1H1 STRN4 25348397 N/A physical interaction ComPPI
DYNC1H1 NUP133 25348397 N/A physical interaction ComPPI
DYNC1H1 TNKS1BP1 25348397 N/A physical interaction ComPPI
DYNC1H1 LONP1 25348397 N/A physical interaction ComPPI
DYNC1H1 EPPK1 25348397 N/A physical interaction ComPPI
DYNC1H1 MCCC1 25348397 N/A physical interaction ComPPI
DYNC1H1 MCCC2 25348397 N/A physical interaction ComPPI
DYNC1H1 HEXIM1 25348397 N/A physical interaction ComPPI
DYNC1H1 ZC3H4 25348397 N/A physical interaction ComPPI
DYNC1H1 LRRFIP1 25348397 N/A physical interaction ComPPI
DYNC1H1 BRCA1 25348397 N/A physical interaction ComPPI
DYNC1H1 ELP1 25348397 N/A physical interaction ComPPI
DYNC1H1 HSP90AA2P 25348397 N/A physical interaction ComPPI
DYNC1H1 FN1 25348397 N/A physical interaction ComPPI
DYNC1H1 PEX14 21525035 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
DYNC1H1 METTL21A 25348397 N/A physical interaction ComPPI
DYNC1H1 DDX1 25348397 N/A physical interaction ComPPI
DYNC1H1 DYNC1I2 25348397 N/A physical interaction ComPPI
DYNC1H1 PRUNE2 25348397 N/A physical interaction ComPPI
DYNC1H1 SERBP1 25348397 N/A physical interaction ComPPI
DYNC1H1 EIF3K 25348397 N/A physical interaction ComPPI
DYNC1H1 RPS24 25348397 N/A physical interaction ComPPI
DYNC1H1 RPS5 25348397 N/A physical interaction ComPPI
DYNC1H1 DYNC1I1 25348397 N/A physical interaction ComPPI
DYNC1H1 SPRTN 25348397 N/A physical interaction ComPPI
DYNC1H1 OBSL1 25348397 N/A physical interaction ComPPI
DYNC1H1 CCDC8 25348397 N/A physical interaction ComPPI
DYNC1H1 SUZ12 25348397 N/A physical interaction ComPPI
DYNC1H1 FBXW11 25348397 N/A physical interaction ComPPI
DYNC1H1 UNK 25348397 N/A physical interaction ComPPI
DYNC1H1 DCTN2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 NCBP1 25348397 N/A physical interaction ComPPI
DYNC1H1 PIN4 25348397 N/A physical interaction ComPPI
DYNC1H1 RUVBL2 25348397 N/A physical interaction ComPPI
DYNC1H1 OFD1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DYNC1H1 CNTRL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DYNC1H1 NINL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DYNC1H1 NIN 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DYNC1H1 RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DYNC1H1 SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DYNC1H1 POC5 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DYNC1H1 PPP2R3C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 HNRNPD 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
DYNC1H1 MKLN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 CLIP1 25348397 N/A physical interaction ComPPI
DYNC1H1 TPD52 25348397 N/A physical interaction ComPPI
DYNC1H1 RPRD2 25348397 N/A physical interaction ComPPI
DYNC1H1 BICRA 25348397 N/A physical interaction ComPPI
DYNC1H1 DCTN4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 DCTN5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNC1H1 NUMA1 25348397 N/A physical interaction ComPPI
DYNC1H1 SKI 25348397 N/A physical interaction ComPPI
DYNC1H1 CRY2 25348397 N/A physical interaction ComPPI
DYNC1H1 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
DYNC1H1 ATOH1 25348397 N/A physical interaction ComPPI
DYNC1H1 ZNF746 25348397 N/A physical interaction ComPPI
DYNC1H1 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
DYNC1H1 CYLD 25348397 N/A physical interaction ComPPI
DYNC1H1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DYNC1H1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DYNC1H1 HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DYNC1H1 TES 25348397 N/A physical interaction ComPPI
DYNC1H1 STK40 25348397 N/A physical interaction ComPPI
DYNC1H1 IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DYNC1H1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DYNC1H1 NF1 23583712 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
DYNC1H1 ESR1 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
DYNC1H1 TCTE1 24234451 25348397 26638075 association proximity-dependent biotin identification ComPPI,IntAct
DYNC1H1 DUX4 24234451 25348397 26816005 association pull down ComPPI,IntAct
DYNC1H1 KATNAL2 24234451 25348397 26929214 association tandem affinity purification ComPPI,IntAct
EEF1D DYNC1H1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
METTL21C DYNC1H1 25348397 N/A physical interaction ComPPI
HSCB DYNC1H1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
ZNF16 DYNC1H1 21874239 24234451 25348397 physical association two hybrid ComPPI,IntAct
DYNC1H1 DYNC1H1 21723285 24234451 N/A electron microscopy IntAct

Visualization










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