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GENE：DYRK1A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DYRK1A
FullNmae dual specificity tyrosine phosphorylation regulated kinase 1A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3091
EnsembleID ENSG00000157540
Uniprot Q13627

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DYRK1A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DYRK1A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DYRK1A GO:0003713,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0004712,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005737,GO:0005856,GO:0006338,GO:0006357,GO:0006468,GO:0006468,GO:0007399,GO:0007623,GO:0008353,GO:0016607,GO:0016607,GO:0018105,GO:0018105,GO:0018105,GO:0018107,GO:0018107,GO:0018108,GO:0018108,GO:0030424,GO:0030425,GO:0031115,GO:0033120,GO:0034205,GO:0036289,GO:0038083,GO:0038083,GO:0042802,GO:0043518,GO:0043621,GO:0045893,GO:0046777,GO:0048025,GO:0048156,GO:0048156,GO:0050321,GO:0090310,GO:0090312,GO:0106310,GO:0140857,GO:1990904

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DYRK1A FOXO1 11980723 12138125 16511445 19685005 26192618 interaction type N/A ACSN
DYRK1A GLI1 11980723 12138125 16511445 19685005 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink
DYRK1A SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
TRAF3 DYRK1A 22792062 23180781 physical association anti tag coimmunoprecipitation InnateDB
ISG15 DYRK1A 16009940 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
AR DYRK1A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DYRK1A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DYRK1A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DYRK1A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 DYRK1A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 DYRK1A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DYRK1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
REST DYRK1A 21252229 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 DYRK1A 18185580 23824327 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS00000F31F4 DYRK1A 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00003BBF48 DYRK1A 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000B59A2 DYRK1A 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000005481D DYRK1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C308D DYRK1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000028C188 DYRK1A 24861464 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr TarBase
URS0000184017 DYRK1A 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 DYRK1A 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002E0524 DYRK1A 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 DYRK1A 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 DYRK1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000366551 DYRK1A 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 DYRK1A 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000237E04 DYRK1A 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 DYRK1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F DYRK1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 DYRK1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5FFC DYRK1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F14FE DYRK1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 DYRK1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411672 DYRK1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D DYRK1A 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DYRK1A AMPH 22135298 phosphorylation N/A PhosphoSite
DYRK1A RCAN1 22135298 phosphorylation N/A PhosphoSite
DYRK1A POLR2A 22135298 phosphorylation N/A PhosphoSite
DYRK1A DYRK1A 22135298 phosphorylation N/A PhosphoSite
DYRK1A NFATC1 22135298 phosphorylation N/A PhosphoSite
DYRK1A SF3B1 22135298 phosphorylation N/A PhosphoSite
DYRK1A CCNL2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
DYRK1A LIN52 22135298 phosphorylation N/A PhosphoSite
DYRK1A SPRY2 22135298 phosphorylation N/A PhosphoSite
DYRK1A TP53 22135298 phosphorylation N/A PhosphoSite
DYRK1A CCND1 22135298 phosphorylation N/A PhosphoSite
DYRK1A FOXO1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
DYRK1A CDKL5 22135298 phosphorylation N/A PhosphoSite
DYRK1A SNCA 22135298 phosphorylation N/A PhosphoSite
DYRK1A DNM1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
GLI1 DYRK1A 25361965 interaction type N/A PTMCode2
DYRK1A GLI1 25361965 interaction type N/A PTMCode2
DNM1 DYRK1A 25361965 interaction type N/A PTMCode2
PHYHIP DYRK1A 25361965 interaction type N/A PTMCode2
DYRK1A PHYHIP 25361965 interaction type N/A PTMCode2
FOXO1 DYRK1A 25361965 interaction type N/A PTMCode2
CCNL2 DYRK1A 25361965 interaction type N/A PTMCode2
DYRK1A CREB1 25361965 interaction type N/A PTMCode2
CREB1 DYRK1A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DYNLL1 DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TBC1D7 DYRK1A 25348397 N/A physical interaction ComPPI
DYNLL2 DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
LZTS2 DYRK1A 23602568 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,bimolecular fluorescence complementation ComPPI,IntAct
ISG15 DYRK1A 25348397 N/A physical interaction ComPPI
FAM53C DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAG DYRK1A 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
FOXR2 DYRK1A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB DYRK1A 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
H4C1 DYRK1A 25348397 N/A physical interaction ComPPI
TBP DYRK1A 25348397 N/A physical interaction ComPPI
RB1 DYRK1A 23602568 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,bimolecular fluorescence complementation ComPPI,IntAct
CREBBP DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EP300 DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 DYRK1A 25348397 N/A physical interaction,tandem affinity purification ComPPI
SF3B1 DYRK1A 14525934 16512921 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CTBP1 DYRK1A 25348397 N/A physical interaction ComPPI
GLI1 DYRK1A 12138125 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKACA DYRK1A 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ABCD3 DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAB DYRK1A 14525934 17229891 17353931 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
PRKAR1A DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NTRK1 DYRK1A 25348397 N/A physical interaction ComPPI
BTRC DYRK1A 25348397 N/A physical interaction ComPPI
DNM1 DYRK1A 25348397 N/A physical interaction ComPPI
RBL2 DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAP3K5 DYRK1A 25348397 N/A physical interaction ComPPI
TRAF3 DYRK1A 25348397 N/A physical interaction ComPPI
NXF2 DYRK1A 25348397 N/A physical interaction ComPPI
XPO1 DYRK1A 25348397 N/A physical interaction ComPPI
CLTC DYRK1A 25348397 N/A physical interaction ComPPI
SRSF1 DYRK1A 18658135 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SFN DYRK1A 15778465 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAE DYRK1A 14525934 15369779 24234451 25348397 physical association experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
MED23 DYRK1A 25348397 N/A physical interaction ComPPI
HIPK2 DYRK1A 20940704 24234451 25348397 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct
TSC1 DYRK1A 25348397 N/A physical interaction ComPPI
SIRT1 DYRK1A 20167603 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
AMPH DYRK1A 25348397 N/A physical interaction ComPPI
PRKN DYRK1A 25348397 N/A physical interaction ComPPI
H3C1 DYRK1A 25348397 N/A physical interaction ComPPI
SH3GL2 DYRK1A 25348397 N/A physical interaction ComPPI
RAD54L2 DYRK1A 25348397 N/A physical interaction ComPPI
BARD1 DYRK1A 25348397 N/A physical interaction ComPPI
SNCA DYRK1A 25348397 N/A physical interaction ComPPI
ID2 DYRK1A 25348397 N/A physical interaction ComPPI
TRIM25 DYRK1A 25348397 N/A physical interaction ComPPI
ELAVL1 DYRK1A 25348397 N/A physical interaction ComPPI
FNTA DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CCNL2 DYRK1A 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SRSF5 DYRK1A 25348397 N/A physical interaction ComPPI
BRCA1 DYRK1A 25348397 N/A physical interaction ComPPI
CCNA2 DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PHYHIP DYRK1A 14525934 15694837 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
SRSF4 DYRK1A 25348397 N/A physical interaction ComPPI
SIPA1L1 DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EGLN2 DYRK1A 25348397 N/A physical interaction ComPPI
TROAP DYRK1A 23602568 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,bimolecular fluorescence complementation ComPPI,IntAct
RBL1 DYRK1A 23602568 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,bimolecular fluorescence complementation ComPPI,IntAct
CLASRP DYRK1A 25348397 N/A physical interaction ComPPI
DCAF7 DYRK1A 20940704 23602568 24234451 25348397 27173435 27705803 colocalization,association,physical association anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
DYRK1A CREB1 14525934 15694837 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DYRK1A FOXO1 11311120 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DYRK1A H2BC3 25348397 N/A physical interaction ComPPI
DYRK1A MAP3K1 20940704 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYRK1A LATS2 25348397 N/A physical interaction ComPPI
DYRK1A LIN52 25348397 N/A physical interaction ComPPI
DYRK1A APP 25348397 N/A physical interaction ComPPI
DYRK1A FAM117B 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DYRK1A GLCCI1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DYRK1A FAM117A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DYRK1A RNF169 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DYRK1A FNTB 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DYRK1A PPP1R3F 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DYRK1A KIAA0232 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DYRK1A CCDC8 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DYRK1A MOV10 25348397 N/A physical interaction ComPPI
DYRK1A NXF1 25348397 N/A physical interaction ComPPI
DYRK1A RFPL2 25348397 N/A physical interaction ComPPI
DYRK1A LIPH 25348397 N/A physical interaction ComPPI
DYRK1A CEFIP 25348397 N/A physical interaction ComPPI
DYRK1A LRCH3 25348397 N/A physical interaction ComPPI
DYRK1A KPRP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DYRK1A DYRK1A 14525934 17229891 N/A experimental interaction detection HPRD
TRAF2 DYRK1A 24234451 30561431 association virotrap IntAct
DYRK1A DNM1 11877424 15287745 17376771 19722700 27898060 inhibition N/A OmniPath
DYRK1A EIF2S1 11311121 27898060 inhibition N/A OmniPath
DYRK1A FOXO4 11313479 11689711 11896584 15538382 19188143 27898060 inhibition N/A OmniPath
DYRK1A FOXO3 19188143 27898060 inhibition N/A OmniPath
DYRK1A FOXO1 10358014 10358075 11311120 11410590 11980723 19188143 27898060 inhibition,stimulant N/A OmniPath
DYRK1A SIRT1 19107194 19690332 20027304 20167603 27898060 N/A N/A OmniPath
DYRK1A TP53 20696760 27898060 stimulant N/A OmniPath
DYRK1A GLI1 12138125 27898060 stimulant N/A OmniPath
DYRK1A NOTCH1 19383720 27898060 inhibition N/A OmniPath
DYRK1A CCND1 24119401 27898060 inhibition N/A OmniPath
DYRK1A RCAN1 12809556 16126726 27898060 stimulant N/A OmniPath
ISG15 DYRK1A 16009940 27898060 N/A N/A OmniPath
DYRK1A MAPT 11311121 21215781 27898060 inhibition N/A OmniPath
DYRK1A SNCA 16959772 27898060 stimulant N/A OmniPath
TRAF3 DYRK1A 22792062 27898060 N/A N/A OmniPath
DYRK1A CDC34 11546811 12037680 27898060 N/A N/A OmniPath
DYRK1A SPRY2 12593795 12815057 15637081 16000370 18678649 20804972 27898060 inhibition N/A OmniPath
DYRK1A TRIO 12551902 27898060 N/A N/A OmniPath
DYRK1A AMPH 11113134 15262992 16733250 27898060 inhibition N/A OmniPath
DYRK1A PTPN12 27898060 7520867 7909431 N/A N/A OmniPath
DYRK1A FOXO6 19188143 27898060 inhibition N/A OmniPath
DYRK1A SF3B1 16512921 20068231 27898060 stimulant N/A OmniPath
DYRK1A CCNL2 14623875 18452278 18669648 19413330 19651622 19664994 19664995 20068231 27898060 stimulant N/A OmniPath

Visualization










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