GENE：EXT1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EXT1 |
| FullNmae | exostosin glycosyltransferase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3512 |
| EnsembleID | ENSG00000182197 |
| Uniprot | Q16394 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EXT1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EXT1 | GO:0000139,GO:0000271,GO:0001501,GO:0001503,GO:0001958,GO:0001974,GO:0002067,GO:0002524,GO:0003128,GO:0003415,GO:0003416,GO:0005515,GO:0005783,GO:0005789,GO:0005789,GO:0005794,GO:0005794,GO:0006024,GO:0007033,GO:0007165,GO:0007369,GO:0007411,GO:0007492,GO:0007498,GO:0008217,GO:0008375,GO:0008375,GO:0008543,GO:0009642,GO:0010467,GO:0014033,GO:0015012,GO:0015012,GO:0015014,GO:0015020,GO:0015020,GO:0016020,GO:0016757,GO:0017145,GO:0019882,GO:0021554,GO:0021772,GO:0030163,GO:0030199,GO:0030204,GO:0030210,GO:0030509,GO:0031069,GO:0032836,GO:0033627,GO:0035176,GO:0035249,GO:0035264,GO:0035988,GO:0036022,GO:0036336,GO:0036339,GO:0042044,GO:0042060,GO:0042311,GO:0042328,GO:0042596,GO:0042803,GO:0043931,GO:0045165,GO:0045202,GO:0045453,GO:0046872,GO:0046982,GO:0048733,GO:0050508,GO:0050508,GO:0050509,GO:0050509,GO:0050891,GO:0050901,GO:0051923,GO:0055078,GO:0060047,GO:0060070,GO:0060218,GO:0060351,GO:0060441,GO:0060506,GO:0060560,GO:0060792,GO:0061484,GO:0061744,GO:0061974,GO:0062094,GO:0065003,GO:0070593,GO:0071503,GO:0071625,GO:0071711,GO:0071847,GO:0072112,GO:0072498,GO:0097021,GO:0097241,GO:0098586,GO:0120193,GO:1901706,GO:1904888,GO:1990823 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| EXT1 | hsa:2131 | path:hsa00534 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human) |
| EXT1 | hsa:2131 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | EXT1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | EXT1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | EXT1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | EXT1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | EXT1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | EXT1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | EXT1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | EXT1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | EXT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF1 | EXT1 | 22037484 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000ED600 | EXT1 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00003CF1AD | EXT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000214763 | EXT1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000047A8F | EXT1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A6D0C | EXT1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | EXT1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000059EB31 | EXT1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC4BD | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000284586 | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000475586 | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002ED720 | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000192A75 | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | EXT1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B0B46 | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F6E49 | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004DA9DB | EXT1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | EXT1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CF3F0 | EXT1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CNTF | EXT1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FBXW7 | EXT1 | 25348397 | N/A | physical interaction | ComPPI |
| NOTCH1 | EXT1 | 25348397 | N/A | physical interaction | ComPPI |
| PEX19 | EXT1 | 25348397 | N/A | physical interaction | ComPPI |
| PLAUR | EXT1 | 25348397 | N/A | physical interaction | ComPPI |
| TRAP1 | EXT1 | 10545594 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| SYP | EXT1 | 25348397 | N/A | physical interaction | ComPPI |
| TFR2 | EXT1 | 25348397 | N/A | physical interaction | ComPPI |
| OSTF1 | EXT1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CD79B | EXT1 | 25348397 | N/A | physical interaction | ComPPI |
| MYH1 | EXT1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| SCGB2A2 | EXT1 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | EXT2 | 10639137 10679296 25348397 27898060 | N/A | physical interaction,in vitro,in vivo | ComPPI,OmniPath |
| EXT1 | SYNE4 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | ERGIC3 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | NAAA | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | B4GAT1 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | MPPE1 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | CRP | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | GAA | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | SLC39A5 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | NRROS | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | TOR1AIP2 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | TOR1AIP2 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | EXT1 | 10639137 10679296 14525934 | N/A | experimental interaction detection | HPRD |