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GENE：MAML1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAML1
FullNmae mastermind like transcriptional coactivator 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13632
EnsembleID ENSG00000161021
Uniprot Q92585

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAML1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAML1 GO:0002193,GO:0003162,GO:0003713,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006468,GO:0007219,GO:0007221,GO:0010831,GO:0016607,GO:0019901,GO:0042605,GO:0045445,GO:0045944,GO:0060928

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAML1 hsa:9794 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
MAML1 hsa:9794 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
MAML1 hsa:9794 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MAML1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MAML1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 MAML1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A MAML1 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
YBX1 MAML1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR MAML1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC7 MAML1 20203086 trascriptional regulation,stimulation inferred by curator TFlink
HDAC9 MAML1 20203086 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F4AC3 MAML1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001DE669 MAML1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F MAML1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 MAML1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 MAML1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB MAML1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000048B5E9 MAML1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NOTCH1 MAML1 25361965 interaction type N/A PTMCode2
MAML1 NOTCH1 25361965 interaction type N/A PTMCode2
NOTCH3 MAML1 25361965 interaction type N/A PTMCode2
MAML1 NOTCH3 25361965 interaction type N/A PTMCode2
MAML1 RBPJ 25361965 interaction type N/A PTMCode2
RBPJ MAML1 25361965 interaction type N/A PTMCode2
MAML1 NOTCH4 25361965 interaction type N/A PTMCode2
NOTCH4 MAML1 25361965 interaction type N/A PTMCode2
MAML1 MAML2 25361965 interaction type N/A PTMCode2
MAML2 MAML1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EGLN3 MAML1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
NOTCH4 MAML1 11101851 11585921 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAML1 NOTCH1 11101851 12644465 14525934 16530044 18427106 19907488 20972443 22325781 23022380 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
MAML1 CREBBP 12050117 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAML1 NOTCH2 11101851 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAML1 NOTCH3 11101851 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAML1 EP300 12050117 12391150 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAML1 CDK8 14525934 15546612 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAML1 RBPJ 14525934 16530044 17284587 19907488 21475249 23022380 24234451 25348397 25609649 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
MAML1 MAML2 25348397 N/A physical interaction ComPPI
MAML1 MAML3 25348397 N/A physical interaction ComPPI
MAML1 PIAS1 25348397 N/A physical interaction ComPPI
MAML1 HDAC9 20203086 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAML1 PHF8 23022380 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAML1 SMARCA4 23022380 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAML1 PBRM1 23022380 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAML1 EWSR1 25348397 N/A physical interaction ComPPI
MAML1 XPO1 25348397 N/A physical interaction ComPPI
MAML1 HUWE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAML1 RND3 25348397 N/A physical interaction ComPPI
MAML1 ZMIZ1 25348397 N/A physical interaction ComPPI
MAML1 RMND5A 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
MAML1 FRYL 23022380 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAML1 KDM1A 23022380 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAML1 MAML1 11101851 14525934 N/A experimental interaction detection HPRD
MAML1 CTNNB1 17875709 27898060 stimulant N/A OmniPath
MAML1 H4C1 17300219 27898060 inhibition N/A OmniPath
FOXO1 MAML1 18391971 27898060 stimulant N/A OmniPath
MAML1 H3C1 17300219 27898060 stimulant N/A OmniPath
MAML1 TP53 18758483 27898060 stimulant N/A OmniPath
MAML1 RBPJ 11101851 11997524 16530044 16921404 17145710 23022380 25609649 26186194 26496610 27898060 stimulant N/A OmniPath
EP300 MAML1 12050117 12391150 15546612 16530044 17300219 19304754 27898060 stimulant N/A OmniPath
MAML1 EP300 12050117 12391150 15546612 16530044 17300219 19304754 27898060 stimulant N/A OmniPath
MAML1 NOTCH1 11101851 11390662 11997524 12370315 12644465 16530044 21820430 22100894 23022380 27898060 inhibition,stimulant N/A OmniPath
GSK3B MAML1 19740771 27898060 inhibition N/A OmniPath
MAML1 NOTCH2 11101851 27898060 stimulant N/A OmniPath
MAML1 NOTCH3 11101851 27898060 stimulant N/A OmniPath
MAML1 CDK8 15546612 27898060 stimulant N/A OmniPath
MAML1 NOTCH4 11101851 11585921 27898060 stimulant N/A OmniPath
MAML1 CCNC 15546612 27898060 stimulant N/A OmniPath
MAML1 CCNT1 15546612 27898060 stimulant N/A OmniPath
MAML1 MEF2C 16510869 27898060 stimulant N/A OmniPath

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