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GENE：P2RX4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol P2RX4
FullNmae purinergic receptor P2X 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8535
EnsembleID ENSG00000135124
Uniprot Q99571

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
P2RX4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
P2RX4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
P2RX4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
P2RX4 GO:0001614,GO:0001614,GO:0001894,GO:0002028,GO:0002931,GO:0004931,GO:0004931,GO:0005102,GO:0005507,GO:0005515,GO:0005524,GO:0005765,GO:0005765,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0007165,GO:0008217,GO:0008270,GO:0010524,GO:0010524,GO:0010614,GO:0016020,GO:0016020,GO:0019228,GO:0019233,GO:0019722,GO:0030054,GO:0032308,GO:0033198,GO:0034220,GO:0034405,GO:0035590,GO:0042118,GO:0042802,GO:0043025,GO:0043195,GO:0043197,GO:0043536,GO:0044297,GO:0045296,GO:0045429,GO:0048266,GO:0048471,GO:0048678,GO:0050850,GO:0050850,GO:0050920,GO:0050975,GO:0051897,GO:0051899,GO:0051928,GO:0055117,GO:0055119,GO:0060079,GO:0070062,GO:0070588,GO:0070588,GO:0071294,GO:0071318,GO:0097190,GO:0099604,GO:0099604,GO:1904141,GO:1904141,GO:2001028

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
P2RX4 hsa:5025 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
P2RX4 hsa:5025 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 P2RX4 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 P2RX4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 P2RX4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 P2RX4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 P2RX4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 P2RX4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 P2RX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA P2RX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF P2RX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 P2RX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 P2RX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS P2RX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 P2RX4 11299224 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 P2RX4 11299224 trascriptional regulation,stimulation inferred by curator TFlink
TP53 P2RX4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 P2RX4 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
P2RX4 CDH5 25361965 interaction type N/A PTMCode2
CDH5 P2RX4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRTAP5-9 P2RX4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EIF2B2 P2RX4 25348397 N/A physical interaction ComPPI
MCM2 P2RX4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ORC4 P2RX4 25348397 N/A physical interaction ComPPI
CDH5 P2RX4 12088286 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PIGH P2RX4 25348397 N/A physical interaction ComPPI
EIF2B1 P2RX4 25348397 N/A physical interaction ComPPI
EIF2B5 P2RX4 25348397 N/A physical interaction ComPPI
KCNJ8 P2RX4 25348397 N/A physical interaction ComPPI
TNPO3 P2RX4 25348397 N/A physical interaction ComPPI
P2RX4 WNT4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
P2RX4 NOTCH2NLA 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
P2RX4 CYBC1 25348397 N/A physical interaction ComPPI
P2RX4 EMC1 25348397 N/A physical interaction ComPPI
P2RX4 FDFT1 25348397 N/A physical interaction ComPPI
P2RX4 ARMCX3 25348397 N/A physical interaction ComPPI
P2RX4 FAM20B 25348397 N/A physical interaction ComPPI
P2RX4 GALNT1 25348397 N/A physical interaction ComPPI
P2RX4 SPTLC2 25348397 N/A physical interaction ComPPI
P2RX4 PGAP4 25348397 N/A physical interaction ComPPI
P2RX4 HS2ST1 25348397 N/A physical interaction ComPPI
P2RX4 COQ8B 25348397 N/A physical interaction ComPPI
P2RX4 EIF2B3 25348397 N/A physical interaction ComPPI
P2RX4 EIF2B4 25348397 N/A physical interaction ComPPI
P2RX4 SAAL1 25348397 N/A physical interaction ComPPI
P2RX4 DNAJC19 25348397 N/A physical interaction ComPPI
P2RX4 EMC7 25348397 N/A physical interaction ComPPI
P2RX4 PLD6 25348397 N/A physical interaction ComPPI
P2RX4 SPPL2B 25348397 N/A physical interaction ComPPI
P2RX4 CSGALNACT2 25348397 N/A physical interaction ComPPI
P2RX4 GLT8D1 25348397 N/A physical interaction ComPPI
P2RX4 KRTAP1-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
P2RX4 KRTAP12-3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DNAAF6 P2RX4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
P2RX4 P2RX7 17785580 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BBB77 P2RX4 27087310 direct interaction,inhibition N/A NPInter

Visualization










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