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GENE：MAP3K4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K4
FullNmae mitogen-activated protein kinase kinase kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6856
EnsembleID ENSG00000085511
Uniprot Q9Y6R4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K4 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP3K4 GO:0000165,GO:0001890,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0010225,GO:0010468,GO:0016310,GO:0019100,GO:0032212,GO:0035556,GO:0043507,GO:0046872,GO:0048471,GO:0051973,GO:0060718,GO:0106310,GO:1900745,GO:1904355

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K4 hsa:4216 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP3K4 hsa:4216 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K4 MAP2K4 11175814 11274345 12738796 16799472 18855897 21614932 23331499 23850759 24104473 26192618 9305639 9841871 interaction type,stimulation N/A ACSN,SignaLink
GADD45B MAP3K4 11175814 14691480 23180781 24104473 26192618 9827804 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
GADD45G MAP3K4 11371360 23180781 24104473 26192618 9827804 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MAP3K4 MAP2K3 11175814 11274345 12738796 16799472 18855897 21614932 23850759 24104473 26192618 interaction type N/A ACSN
MAP3K4 MAP2K6 11175814 11274345 12738796 16799472 18855897 21614932 23331499 23850759 24104473 26192618 9305639 9841871 interaction type,stimulation N/A ACSN,SignaLink
CDK5 MAP3K4 21922195 23589330 23850759 26192618 interaction type N/A ACSN
MAP2K4 MAP3K4 23180781 9305639 9841871 phosphorylation reaction in-gel kinase assay InnateDB
MAP2K3 MAP3K4 23180781 9841871 phosphorylation reaction in-gel kinase assay InnateDB
MAP2K6 MAP3K4 23180781 9305639 9841871 phosphorylation reaction in-gel kinase assay InnateDB
RACK1 MAP3K4 18836437 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K4 MAP3K4 17242196 21152872 26467481 9305639 9841871 interaction type,phosphorylation reaction,up-regulates activity N/A Signor
AXIN1 MAP3K4 12878610 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AXIN1 MAP3K4 20005715 interaction type N/A PSP
GADD45B MAP3K4 20005715 interaction type N/A PSP
GADD45G MAP3K4 20005715 interaction type N/A PSP
AXIN1 MAP3K4 20005715 20005715 N/A N/A SignaLink
GADD45B MAP3K4 14743220 16256071 18988627 20005715 20005715 21071413 9827804 9827804 9827804 N/A N/A SignaLink
GADD45G MAP3K4 18988627 20005715 20005715 21071413 9827804 9827804 9827804 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP3K4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MAP3K4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MAP3K4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAP3K4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TAL1 MAP3K4 20028976 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MAP3K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP3K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP3K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAP3K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP3K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP3K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP3K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAP3K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MAP3K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003BBF48 MAP3K4 23622248 25416803 26253263 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clash,miRNA interference luciferase reporter assay TarBase
URS00000DDD35 MAP3K4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000029EBD MAP3K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075D2F5 MAP3K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000939AF MAP3K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 MAP3K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 MAP3K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 MAP3K4 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K4 MAP3K4 22135298 phosphorylation N/A PhosphoSite
MAP2K3 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 MAP2K3 25361965 interaction type N/A PTMCode2
ANXA2 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 ANXA2 25361965 interaction type N/A PTMCode2
PTK2B MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 PTK2B 25361965 interaction type N/A PTMCode2
GADD45A MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 GADD45A 25361965 interaction type N/A PTMCode2
AXIN1 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 AXIN1 25361965 interaction type N/A PTMCode2
RAC1 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 RAC1 25361965 interaction type N/A PTMCode2
MAP3K4 SH3KBP1 25361965 interaction type N/A PTMCode2
SH3KBP1 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 DIXDC1 25361965 interaction type N/A PTMCode2
DIXDC1 MAP3K4 25361965 interaction type N/A PTMCode2
TRAF4 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 TRAF4 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 MAP2K4 25361965 interaction type N/A PTMCode2
CDC42 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 CDC42 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC42 MAP3K4 14525934 24234451 25241761 25348397 9079650 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
SH3KBP1 MAP3K4 16256071 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
GADD45G MAP3K4 12052864 14525934 24234451 25348397 9827804 physical association two hybrid,experimental interaction detection,dihydrofolate reductase reconstruction,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
BAG3 MAP3K4 25348397 N/A physical interaction ComPPI
SGTB MAP3K4 25348397 N/A physical interaction ComPPI
PTPN6 MAP3K4 15601262 24234451 25348397 dephosphorylation reaction,colocalization experimental interaction detection,imaging technique ComPPI,IntAct
RAC1 MAP3K4 14525934 25348397 9305638 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BTK MAP3K4 25348397 N/A physical interaction ComPPI
PTK2B MAP3K4 14525934 15601262 15881658 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,imaging technique,in vitro ComPPI,HPRD,IntAct
RACGAP1 MAP3K4 14525934 25348397 9079650 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK8 MAP3K4 25348397 N/A physical interaction ComPPI
PTPN11 MAP3K4 14525934 15601262 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RUNX2 MAP3K4 14525934 15262978 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GSK3B MAP3K4 25348397 N/A physical interaction ComPPI
GADD45B MAP3K4 12052864 14525934 14743220 16256071 24234451 25348397 9827804 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,dihydrofolate reductase reconstruction,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
YWHAZ MAP3K4 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
UBC MAP3K4 16256071 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
AXIN1 MAP3K4 14525934 15262978 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BAG6 MAP3K4 25348397 N/A physical interaction ComPPI
MAP2K4 MAP3K4 14525934 25348397 9841871 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K1 MAP3K4 14525934 25348397 9841871 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K4 MAP2K6 12052864 14525934 24234451 25241761 25348397 9841871 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
MAP3K4 MAP2K3 24234451 25241761 25348397 physical association physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,IntAct
MAP3K4 BUB1B 14525934 25348397 9482735 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP3K4 MAPK13 14525934 24234451 25241761 25348397 9841871 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
MAP3K4 DIXDC1 14525934 15262978 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP3K4 TRAF4 14525934 16157600 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAP3K4 ANXA2 14525934 15601262 15881658 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
MAP3K4 GADD45A 12052864 14525934 24234451 25348397 9827804 physical association two hybrid,experimental interaction detection,dihydrofolate reductase reconstruction,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MAP3K4 ALK 25348397 N/A physical interaction ComPPI
MAP3K4 TPR 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP3K4 CNTRL 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP3K4 ZFP36 25348397 N/A physical interaction ComPPI
MAP3K4 MAP2K7 25348397 N/A physical interaction ComPPI
MAP3K4 RIPK2 25348397 N/A physical interaction ComPPI
MAP3K4 CHUK 25348397 N/A physical interaction ComPPI
MAP3K4 HNRNPD 25348397 N/A physical interaction ComPPI
MAP3K4 POLR2F 25348397 N/A physical interaction ComPPI
MAP3K4 RAP1B 25348397 N/A physical interaction ComPPI
MAP3K4 SORT1 25348397 N/A physical interaction ComPPI
MAP3K4 SRPRA 25348397 N/A physical interaction ComPPI
MAP3K4 KIF23 25348397 N/A physical interaction ComPPI
MAP3K4 SYNCRIP 25348397 N/A physical interaction ComPPI
MAP3K4 AP4E1 25348397 N/A physical interaction ComPPI
MAP3K4 GOLT1B 25348397 N/A physical interaction ComPPI
MAP3K4 KIF21A 25348397 N/A physical interaction ComPPI
MAP3K4 INTS14 25348397 N/A physical interaction ComPPI
MAP3K4 CNTROB 25348397 N/A physical interaction ComPPI
MAP3K4 NEDD1 25348397 N/A physical interaction ComPPI
MAP3K4 KIF7 25348397 N/A physical interaction ComPPI
MAP3K4 USF1 25348397 N/A physical interaction ComPPI
MAP3K4 SPATA1 25348397 N/A physical interaction ComPPI
MAP3K4 ACTBL2 25348397 N/A physical interaction ComPPI
MAP3K4 SIGLECL1 25348397 N/A physical interaction ComPPI
MAP3K4 FLNB 19270716 24234451 25348397 association,physical association pull down ComPPI,IntAct
MAP3K4 TBK1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
MAP3K4 MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
MAP3K4 MAP3K4 12052864 14525934 24234451 physical association two hybrid,two hybrid HPRD,IntAct
RPS25 MAP3K4 24234451 30021884 physical association cross-linking study IntAct
BOP1 MAP3K4 24234451 30021884 physical association cross-linking study IntAct
MAP3K4 RACK1 18836437 27898060 N/A N/A OmniPath
MAP3K7 MAP3K4 27898060 9890973 stimulant N/A OmniPath
MAP2K4 MAP3K4 11274345 12738796 15866172 18855897 21614932 27898060 9305639 9841871 N/A N/A OmniPath
MAP3K4 MAP2K4 11274345 12738796 15866172 18855897 21614932 27898060 9305639 9841871 stimulant N/A OmniPath
MAP2K3 MAP3K4 11274345 12738796 15866172 18855897 21614932 25241761 27898060 9305639 9841871 N/A N/A OmniPath
MAP3K4 MAP2K3 11274345 12738796 15866172 18855897 21614932 25241761 27898060 9305639 9841871 stimulant N/A OmniPath
MAP3K4 MAPK14 21152872 27898060 stimulant N/A OmniPath
GADD45B MAP3K4 14743220 16256071 27898060 9827804 stimulant N/A OmniPath
MAP3K4 MAP2K6 11274345 12052864 12738796 15866172 16157600 17726008 18855897 21614932 25241761 27898060 9305639 9841871 stimulant N/A OmniPath
PTPN11 MAP3K4 15601262 27898060 inhibition N/A OmniPath
AXIN1 MAP3K4 12878610 15262978 27898060 stimulant N/A OmniPath
GSK3B MAP3K4 17726008 27898060 inhibition N/A OmniPath
MAP3K4 GADD45G 27898060 9827804 N/A N/A OmniPath
MAP3K4 MAP4K3 27898060 9305639 stimulant N/A OmniPath
MAP3K4 MINK1 27898060 9305639 stimulant N/A OmniPath

Visualization










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