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GENE：KPNA4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KPNA4
FullNmae karyopherin subunit alpha 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6397
EnsembleID ENSG00000186432
Uniprot O00629

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KPNA4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KPNA4 GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005654,GO:0005654,GO:0005654,GO:0005829,GO:0005829,GO:0006606,GO:0006607,GO:0008139,GO:0010467,GO:0014046,GO:0031965,GO:0042564,GO:0061608,GO:0061608

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KPNA4 hsa:3840 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)
KPNA4 hsa:3840 path:hsa05132 Salmonella infection - Homo sapiens (human)
KPNA4 hsa:3840 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KPNA4 IRF9 15175343 23180781 physical association gst pull down InnateDB
WAS KPNA4 23180781 24872192 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR KPNA4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 KPNA4 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 KPNA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KPNA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 KPNA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 KPNA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 KPNA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 KPNA4 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065D58 KPNA4 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000427B68 KPNA4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB KPNA4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 KPNA4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 KPNA4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D KPNA4 21572407 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005ACA7C KPNA4 21572407 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000008A99 KPNA4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F KPNA4 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000000C73C KPNA4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 KPNA4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 KPNA4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 KPNA4 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 KPNA4 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 KPNA4 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000081E1F KPNA4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 KPNA4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 KPNA4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 KPNA4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001799A3 KPNA4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000364FEF KPNA4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000017CCCB KPNA4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075BEA7 KPNA4 25416803 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00002C02E4 KPNA4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000019D79B KPNA4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000031D186 KPNA4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000250A40 KPNA4 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KPNA4 RECQL 25361965 interaction type N/A PTMCode2
RECQL KPNA4 25361965 interaction type N/A PTMCode2
KPNB1 KPNA4 25361965 interaction type N/A PTMCode2
KPNA4 KPNB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 KPNA4 25348397 N/A physical interaction ComPPI
DAXX KPNA4 25348397 N/A physical interaction ComPPI
FAM50B KPNA4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HNRNPC KPNA4 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA3 KPNA4 25348397 N/A physical interaction ComPPI
KPNA4 PLAA 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA4 TGM2 10100610 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
KPNA4 RECQL 14525934 24234451 25348397 9168958 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
KPNA4 ARRB2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA4 CSE1L 25348397 N/A physical interaction ComPPI
KPNA4 KPNB1 10523667 20818336 24234451 25348397 26496610 association anti tag coimmunoprecipitation,pull down,surface plasmon resonance,physical interaction ComPPI,IntAct
KPNA4 RAC1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
KPNA4 RCC1 25348397 N/A physical interaction ComPPI
KPNA4 H3-3A 25348397 N/A physical interaction ComPPI
KPNA4 TP53 19927155 25348397 27898060 N/A physical interaction ComPPI,OmniPath
KPNA4 MYC 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
KPNA4 CTCF 25348397 N/A physical interaction ComPPI
KPNA4 CUL4B 25348397 N/A physical interaction ComPPI
KPNA4 CDKN1B 25348397 N/A physical interaction ComPPI
KPNA4 EXO1 25348397 N/A physical interaction ComPPI
KPNA4 ELAVL1 25348397 N/A physical interaction ComPPI
KPNA4 PARD3 25348397 N/A physical interaction ComPPI
KPNA4 CUL3 25348397 N/A physical interaction ComPPI
KPNA4 APP 25348397 N/A physical interaction ComPPI
KPNA4 AICDA 25348397 N/A physical interaction ComPPI
KPNA4 CBX5 20562864 21888893 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
KPNA4 CSNK2A1 22113938 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
KPNA4 NACC1 25348397 N/A physical interaction ComPPI
KPNA4 SOX2 25348397 N/A physical interaction ComPPI
KPNA4 HDAC1 23752268 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA4 ACLY 25348397 N/A physical interaction ComPPI
KPNA4 LIN28A 25348397 N/A physical interaction ComPPI
KPNA4 HSF1 24234451 25036637 25348397 27173435 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
KPNA4 NUP50 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA4 MAT2B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA4 CYHR1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA4 MTA1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA4 PHF20L1 25348397 N/A physical interaction ComPPI
KPNA4 IER2 25348397 N/A physical interaction ComPPI
KPNA4 UNK 25348397 N/A physical interaction ComPPI
KPNA4 ACTR1A 25348397 N/A physical interaction ComPPI
KPNA4 ACTR1B 25348397 N/A physical interaction ComPPI
KPNA4 CANX 25348397 N/A physical interaction ComPPI
KPNA4 CLGN 25348397 N/A physical interaction ComPPI
KPNA4 COPB1 25348397 N/A physical interaction ComPPI
KPNA4 HSP90B1 25348397 N/A physical interaction ComPPI
KPNA4 IPO9 25348397 N/A physical interaction ComPPI
KPNA4 AHSA1 25348397 N/A physical interaction ComPPI
KPNA4 CCT2 25348397 N/A physical interaction ComPPI
KPNA4 CCT3 25348397 N/A physical interaction ComPPI
KPNA4 CCT6A 25348397 N/A physical interaction ComPPI
KPNA4 CCT6B 25348397 N/A physical interaction ComPPI
KPNA4 CCT7 25348397 N/A physical interaction ComPPI
KPNA4 CCT8 25348397 N/A physical interaction ComPPI
KPNA4 DNAJA1 25348397 N/A physical interaction ComPPI
KPNA4 LMNB1 25348397 N/A physical interaction ComPPI
KPNA4 MCM4 25348397 N/A physical interaction ComPPI
KPNA4 PC 25348397 N/A physical interaction ComPPI
KPNA4 PRPF8 25348397 N/A physical interaction ComPPI
KPNA4 UQCRC2 25348397 N/A physical interaction ComPPI
KPNA4 SEC63 25348397 N/A physical interaction ComPPI
KPNA4 KIF22 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA4 NCBP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA4 NUP153 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA4 NCBP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA4 LCOR 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA4 NUP107 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA4 MYH7B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA4 CTDSPL2 25348397 N/A physical interaction ComPPI
KPNA4 MECP2 25348397 N/A physical interaction ComPPI
KPNA4 B2M 25348397 N/A physical interaction ComPPI
KPNA4 MRGBP 25348397 N/A physical interaction ComPPI
KPNA4 RAN 25348397 N/A physical interaction ComPPI
KPNA4 SOST 25348397 N/A physical interaction ComPPI
KPNA4 CFAP20 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
KPNA4 FOXA1 25348397 N/A physical interaction ComPPI
KPNA4 WT1 25348397 N/A physical interaction ComPPI
KPNA4 LMNA 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
KPNA4 GTF2IRD1 25348397 N/A physical interaction ComPPI
KPNA4 HIF1A 25348397 N/A physical interaction ComPPI
KPNA4 MED26 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KPNA4 SLX4 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KPNA4 CBX1 21888893 24234451 25348397 association tandem affinity purification ComPPI,IntAct
KPNA4 CBX3 21888893 24234451 25348397 association tandem affinity purification ComPPI,IntAct
KPNA4 SF1 24234451 25348397 26420826 physical association two hybrid fragment pooling approach ComPPI,IntAct
KPNA4 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
KPNA4 HSD3B7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA4 NCBP3 24234451 25348397 26382858 association,physical association two hybrid,pull down,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA4 KAT5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KPNA4 NPM1 20701745 24234451 25348397 N/A pull down ComPPI,IntAct
MKI67 KPNA4 24234451 26949251 association anti tag coimmunoprecipitation IntAct
HSPA8 KPNA4 24234451 30021884 physical association cross-linking study IntAct
KPNA4 NOTCH1 20454918 27898060 stimulant N/A OmniPath
IRF9 KPNA4 15175343 27898060 N/A N/A OmniPath
WAS KPNA4 24872192 27898060 N/A N/A OmniPath

Visualization










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