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GENE：RAD18

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RAD18
FullNmae RAD18 E3 ubiquitin protein ligase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18278
EnsembleID ENSG00000070950
Uniprot Q9NS91

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RAD18 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAD18 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAD18 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RAD18 GO:0000403,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005657,GO:0005737,GO:0005813,GO:0006281,GO:0006301,GO:0006513,GO:0006974,GO:0016604,GO:0031593,GO:0031625,GO:0035861,GO:0042405,GO:0042802,GO:0044877,GO:0046872,GO:0051865,GO:0051984,GO:0061630,GO:0097505,GO:0140678

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR RAD18 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 RAD18 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 RAD18 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RAD18 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RAD18 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000450F92 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002971AB RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000011A030 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000585553 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000BE495 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000383DF4 RAD18 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002AAD6B RAD18 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002AA55A RAD18 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000170CF4 RAD18 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 RAD18 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC7 RAD18 22135298 phosphorylation N/A PhosphoSite
CDK2 RAD18 22135298 phosphorylation N/A PhosphoSite
ATM RAD18 22135298 phosphorylation N/A PhosphoSite
RAD18 HLTF 25361965 interaction type N/A PTMCode2
HLTF RAD18 25361965 interaction type N/A PTMCode2
RAD18 POLH 25361965 interaction type N/A PTMCode2
POLH RAD18 25361965 interaction type N/A PTMCode2
RAD18 PCNA 25361965 interaction type N/A PTMCode2
PCNA RAD18 25361965 interaction type N/A PTMCode2
RAD18 WRNIP1 25361965 interaction type N/A PTMCode2
WRNIP1 RAD18 25361965 interaction type N/A PTMCode2
RAD18 TP53BP1 25361965 interaction type N/A PTMCode2
TP53BP1 RAD18 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 RAD18 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2I RAD18 12226657 19549727 23034805 24224485 24234451 25348397 27898060 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct,OmniPath
SNW1 RAD18 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L RAD18 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PCNA RAD18 25348397 N/A physical interaction ComPPI
ARRDC3 RAD18 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAGEA4 RAD18 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HK2 RAD18 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP1 RAD18 19228710 24234451 25348397 27898060 29656893 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct,OmniPath
JUNB RAD18 25348397 N/A physical interaction ComPPI
RAD18 UBE2B 10884424 10908344 14525934 17720710 18316726 19549727 21422291 24234451 25348397 physical association two hybrid,experimental interaction detection,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
RAD18 UBE2A 10884424 10908344 14525934 19549727 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid ComPPI,HPRD,IntAct
RAD18 HLTF 18316726 18719106 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
RAD18 RAD51 10880451 16224103 18342608 19396164 25348397 25893307 27898060 N/A physical interaction ComPPI,OmniPath
RAD18 POLH 25348397 N/A physical interaction ComPPI
RAD18 POLK 25348397 N/A physical interaction ComPPI
RAD18 TSG101 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAD18 SRRM2 25348397 N/A physical interaction ComPPI
RAD18 FANCD2 20967207 21355096 25348397 25893307 27898060 N/A physical interaction ComPPI,OmniPath
RAD18 FANCI 25348397 N/A physical interaction ComPPI
RAD18 CDC7 25348397 N/A physical interaction ComPPI
RAD18 H2AC1 25348397 N/A physical interaction ComPPI
RAD18 UBC 16196087 17550899 19285159 20935496 22343915 22742833 25162118 25348397 25756347 27898060 N/A physical interaction ComPPI,OmniPath
RAD18 NBN 25348397 N/A physical interaction ComPPI
RAD18 SLF1 22036607 24234451 25348397 26496610 27898060 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
RAD18 SHPRH 25348397 N/A pull down,physical interaction,physical interaction ComPPI
RAD18 SPRTN 25348397 N/A physical interaction ComPPI
RAD18 ORC2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAD18 WRNIP1 25348397 N/A physical interaction ComPPI
RAD18 MAPK8 25348397 N/A physical interaction ComPPI
RAD18 RFC2 25348397 N/A physical interaction ComPPI
RAD18 CPD 25348397 N/A physical interaction ComPPI
RAD18 ZMYM2 25348397 N/A physical interaction ComPPI
RAD18 RPL10A 25348397 N/A physical interaction ComPPI
RAD18 ECT2 25348397 N/A physical interaction ComPPI
RAD18 DTL 25348397 N/A physical interaction ComPPI
RAD18 TRIM23 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAD18 PCGF6 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAD18 TRIM8 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAD18 DZIP3 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAD18 BRCA1 24234451 25348397 29656893 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RAD18 MLKL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAD18 DBF4 25348397 N/A physical interaction ComPPI
RAD18 USP5 25348397 N/A physical interaction ComPPI
RAD18 SIVA1 25348397 N/A physical interaction ComPPI
RAD18 USP2 25348397 N/A physical interaction ComPPI
RAD18 TAX1BP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RAD18 RHNO1 25348397 N/A physical interaction ComPPI
RAD18 MAP3K1 25348397 N/A physical interaction ComPPI
RAD18 PSME3 25348397 N/A physical interaction ComPPI
RAD18 ZNF501 25348397 N/A physical interaction ComPPI
RAD18 RPS2 25348397 N/A physical interaction ComPPI
RAD18 ZFP41 25348397 N/A physical interaction ComPPI
RAD18 LLGL2 25348397 N/A physical interaction ComPPI
RAD18 XPO1 25348397 N/A physical interaction ComPPI
RAD18 CREM 25348397 N/A physical interaction ComPPI
RAD18 ITSN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 SRGAP3 25348397 N/A physical interaction ComPPI
RAD18 TNPO3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 LIN7C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 SLF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 CERK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 SRGAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 ATPAF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 CAVIN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 USP7 25348397 25961918 27898060 N/A physical interaction ComPPI,OmniPath
RAD18 JPH4 25348397 N/A physical interaction ComPPI
RAD18 ZNF692 25348397 N/A physical interaction ComPPI
RAD18 IRF9 25348397 N/A physical interaction ComPPI
RAD18 PIP4K2A 25348397 N/A physical interaction ComPPI
RAD18 TXNIP 25348397 N/A physical interaction ComPPI
RAD18 ARRB2 25348397 N/A physical interaction ComPPI
RAD18 TCEANC2 25348397 N/A physical interaction ComPPI
RAD18 TULP3 25348397 N/A physical interaction ComPPI
RAD18 KLHDC3 25348397 N/A physical interaction ComPPI
RAD18 SRP9 25348397 N/A physical interaction ComPPI
RAD18 UBE2M 25348397 N/A physical interaction ComPPI
RAD18 LLGL1 24234451 24366813 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RAD18 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
RAD18 PDCD5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAD18 DAZAP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAD18 CDK8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
H3C1 RAD18 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATF2 RAD18 25348397 N/A physical interaction ComPPI
ZNF263 RAD18 25348397 N/A physical interaction ComPPI
BATF3 RAD18 25348397 N/A physical interaction ComPPI
RAD18 RAD18 10908344 14525934 N/A experimental interaction detection HPRD
ATP5F1B RAD18 24234451 30021884 physical association cross-linking study IntAct
RAD18 PCNA 15359278 17108083 17720710 18245774 19706603 20064529 20600238 20675655 21227930 21858012 21967848 22904075 23345618 24958773 26170230 27898060 stimulant N/A OmniPath
RNF8 RAD18 19396164 27898060 stimulant N/A OmniPath
RAD18 RAD51C 19396164 27898060 stimulant N/A OmniPath
CDC7 RAD18 21098111 27898060 N/A N/A OmniPath

Visualization










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