GENE：DEFB1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DEFB1 |
| FullNmae | defensin beta 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2766 |
| EnsembleID | ENSG00000164825 |
| Uniprot | P60022 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DEFB1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DEFB1 | GO:0002227,GO:0002227,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005796,GO:0006935,GO:0006955,GO:0007186,GO:0009617,GO:0009617,GO:0016020,GO:0019731,GO:0019933,GO:0031731,GO:0031731,GO:0035584,GO:0042742,GO:0042802,GO:0045087,GO:0045087,GO:0050829,GO:0050829,GO:0050830,GO:0050830,GO:0050830,GO:0060474,GO:0061844,GO:0061844,GO:0070062,GO:0097225,GO:1990742 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DEFB1 | hsa:1672 | path:hsa02010 | ABC transporters - Homo sapiens (human) |
| DEFB1 | hsa:1672 | path:hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DEFB1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | DEFB1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | DEFB1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | DEFB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DEFB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DEFB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DEFB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC1 | DEFB1 | 23185513 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VIM | DEFB1 | 14525934 15383276 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| MAP4K2 | DEFB1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| HAP1 | DEFB1 | 25348397 | N/A | two hybrid,in vitro | ComPPI |
| DEFB1 | RIF1 | 14525934 15383276 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| DEFB1 | CCR6 | 12149255 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| DEFB1 | FBXW5 | 25348397 | N/A | physical interaction | ComPPI |
| DEFB1 | FAM172A | 25348397 | N/A | physical interaction | ComPPI |
| DEFB1 | PM20D2 | 25348397 | N/A | physical interaction | ComPPI |
| DEFB1 | NMT2 | 25348397 | N/A | physical interaction | ComPPI |
| DEFB1 | NMT1 | 25348397 | N/A | physical interaction | ComPPI |
| DEFB1 | PMPCA | 25348397 | N/A | physical interaction | ComPPI |
| DEFB1 | PMPCB | 25348397 | N/A | physical interaction | ComPPI |
| DEFB1 | IDE | 25348397 | N/A | physical interaction | ComPPI |