GENE:COBL
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | COBL |
| FullNmae | cordon-bleu WH2 repeat protein |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:22199 |
| EnsembleID | ENSG00000106078 |
| Uniprot | O75128 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| COBL | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| COBL | GO:0000578,GO:0001726,GO:0001726,GO:0001757,GO:0001843,GO:0001889,GO:0003785,GO:0003785,GO:0005515,GO:0005884,GO:0005884,GO:0005886,GO:0005886,GO:0005938,GO:0016020,GO:0030041,GO:0030041,GO:0030424,GO:0030425,GO:0030903,GO:0033504,GO:0043025,GO:0043025,GO:0044294,GO:0044294,GO:0044295,GO:0044295,GO:0048471,GO:0048471,GO:0048565,GO:0048669,GO:0051639,GO:0051639,GO:1900006,GO:1900029,GO:1990357 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | COBL | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | COBL | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | COBL | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | COBL | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | COBL | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | COBL | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | COBL | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | COBL | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | COBL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPRE1 | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FHL3 | COBL | 25348397 | N/A | physical interaction | ComPPI |
| PACSIN3 | COBL | 25348397 | N/A | physical interaction | ComPPI |
| ACTB | COBL | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CB | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PACSIN1 | COBL | 20936779 24234451 25348397 | physical association | physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| EP300 | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FLNA | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RPA1 | COBL | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | COBL | 25348397 | N/A | physical interaction | ComPPI |
| IQGAP1 | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PDLIM7 | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RPA2 | COBL | 25348397 | N/A | physical interaction | ComPPI |
| RPA3 | COBL | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | COBL | 25348397 | N/A | physical interaction | ComPPI |
| SYNPO | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FBXW11 | COBL | 25348397 | N/A | physical interaction | ComPPI |
| ACTR2 | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PACSIN2 | COBL | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| EZR | COBL | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MYH9 | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MYO1C | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LIMA1 | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DBN1 | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ALAS1 | COBL | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CAPZA2 | COBL | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TMOD3 | COBL | 25348397 | N/A | physical interaction | ComPPI |
| PLEKHA7 | COBL | 24234451 25348397 28877994 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| COBL | CDV3 | 25348397 | N/A | physical interaction | ComPPI |
