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GENE：TTN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TTN
FullNmae titin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12403
EnsembleID ENSG00000155657
Uniprot Q8WZ42

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TTN mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TTN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TTN GO:0000794,GO:0002020,GO:0003300,GO:0004674,GO:0004713,GO:0005509,GO:0005515,GO:0005516,GO:0005516,GO:0005524,GO:0005576,GO:0005829,GO:0006936,GO:0006936,GO:0006941,GO:0007076,GO:0008307,GO:0008307,GO:0010628,GO:0010628,GO:0010737,GO:0016310,GO:0019899,GO:0019901,GO:0030018,GO:0030240,GO:0030241,GO:0031433,GO:0031433,GO:0031674,GO:0035995,GO:0035995,GO:0042802,GO:0042805,GO:0042805,GO:0043621,GO:0045214,GO:0045859,GO:0048769,GO:0050714,GO:0050714,GO:0050790,GO:0051015,GO:0051371,GO:0051592,GO:0055003,GO:0055008,GO:0055013,GO:0060048,GO:0070062,GO:0097493,GO:0097493,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TTN hsa:7273 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
TTN hsa:7273 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TSGA10 TTN 20797700 23180781 physical association affinity chromatography technology InnateDB
TTN GFI1 19506020 23180781 physical association two hybrid InnateDB
ADRB2 TTN 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TTN 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 TTN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 TTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002E92A8 TTN 24453045 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA TTN 22135298 phosphorylation N/A PhosphoSite
CAMK2D TTN 22135298 phosphorylation N/A PhosphoSite
PRKG1 TTN 22135298 phosphorylation N/A PhosphoSite
PRKCA TTN 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
UBE2I TTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ACTN3 TTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
SH3GLB1 TTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
CRYAB TTN 25348397 N/A physical interaction,in vitro ComPPI
RBM3 TTN 25348397 N/A physical interaction ComPPI
IGHG1 TTN 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
AMOT TTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
LMNA TTN 25348397 N/A physical interaction ComPPI
ITGB5 TTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
CALM1 TTN 25348397 N/A cross-linking study,physical interaction ComPPI
KEAP1 TTN 25348397 N/A physical interaction ComPPI
MCM2 TTN 25348397 N/A physical interaction ComPPI
OPTN TTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
MAP1LC3B TTN 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SMURF2 TTN 18157088 24234451 25348397 physical association two hybrid ComPPI,IntAct
TLE3 TTN 25348397 N/A physical interaction ComPPI
MAPK1 TTN 25348397 N/A physical interaction ComPPI
VAV2 TTN 18654987 23414517 24234451 25348397 physical association two hybrid,physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
SP1 TTN 25348397 N/A physical interaction ComPPI
COPS5 TTN 25348397 N/A physical interaction ComPPI
FHL2 TTN 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
FLNA TTN 16902413 24234451 25348397 physical association two hybrid ComPPI,IntAct
TTN NBR1 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
TTN ANK1 25348397 N/A physical interaction,in vitro ComPPI
TTN MYBPC3 25348397 N/A physical interaction,in vitro ComPPI
TTN MYOM1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,in vitro ComPPI,IntAct
TTN MYOM2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,in vitro,proximity ligation assay ComPPI,IntAct
TTN TCAP 11846417 15582318 16962094 19622741 23414517 24234451 25348397 physical association two hybrid,molecular sieving,pull down,x-ray crystallography,physical interaction,two hybrid fragment pooling approach,comigration in non denaturing gel electrophoresis,in vitro,in vivo,atomic force microscopy ComPPI,IntAct
TTN TRIM63 18157088 23414517 24234451 25348397 physical association two hybrid,physical interaction,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,IntAct
TTN OBSCN 11448995 20133654 20489725 23414517 24234451 25348397 physical association two hybrid,fluorescent resonance energy transfer,isothermal titration calorimetry,molecular sieving,pull down,physical interaction,two hybrid fragment pooling approach,in vitro ComPPI,IntAct
TTN ANKRD1 23414517 24234451 25348397 physical association two hybrid,physical interaction,two hybrid fragment pooling approach,in vitro ComPPI,IntAct
TTN ANKRD2 25348397 N/A physical interaction,in vitro ComPPI
TTN ANKRD23 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
TTN ACTN1 11101506 24234451 25348397 physical association two hybrid,pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
TTN CAPN3 20860623 23414517 24234451 25348397 physical association two hybrid,physical interaction,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,IntAct
TTN MYBPC1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,in vitro ComPPI,IntAct
TTN ACTA1 25348397 N/A in vitro ComPPI
TTN ACTN2 11101506 11846417 16902413 23414517 24234451 25348397 9501083 association,physical association two hybrid,protein cross-linking with a bifunctional reagent,isothermal titration calorimetry,pull down,two hybrid fragment pooling approach,in vitro ComPPI,IntAct
TTN MYH9 25348397 N/A in vitro ComPPI
TTN NEB 12482578 16902413 24234451 25348397 physical association circular dichroism,classical fluorescence spectroscopy,two hybrid,filter binding,isothermal titration calorimetry,nuclear magnetic resonance,in vitro,in vivo ComPPI,IntAct
TTN PUF60 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TTN ASF1B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TTN MYPN 25348397 N/A physical interaction ComPPI
TTN ARRB1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TTN SQSTM1 25348397 N/A physical interaction ComPPI
TTN CUL3 25348397 N/A physical interaction ComPPI
TTN CUL4B 25348397 N/A physical interaction ComPPI
TTN CUL2 25348397 N/A physical interaction ComPPI
TTN CDK2 25348397 N/A physical interaction ComPPI
TTN NEDD8 25348397 N/A physical interaction ComPPI
TTN SRSF2 25348397 N/A physical interaction ComPPI
TTN SPEN 25348397 N/A physical interaction ComPPI
TTN CPSF6 25348397 N/A physical interaction ComPPI
TTN ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TTN ADRB2 25348397 N/A physical interaction ComPPI
TTN DYRK2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TTN SRPK2 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
TTN CEP57 25348397 N/A physical interaction ComPPI
TTN TRIM55 25348397 N/A physical interaction ComPPI
TTN RAPGEF2 25348397 N/A physical interaction ComPPI
TTN FHL1 23414517 24234451 25348397 physical association physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
TTN CUL7 25348397 N/A physical interaction ComPPI
TTN RNF2 25348397 N/A physical interaction ComPPI
TTN NTRK1 25348397 N/A physical interaction ComPPI
TTN ANXA7 25348397 N/A physical interaction ComPPI
TTN HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
TTN EWSR1 25348397 N/A physical interaction ComPPI
TTN GAN 25348397 N/A physical interaction ComPPI
TTN TSC22D2 25348397 N/A physical interaction ComPPI
TTN CDH1 25348397 N/A physical interaction ComPPI
TTN EGFR 25348397 N/A physical interaction ComPPI
TTN ADAM2 25348397 N/A physical interaction ComPPI
TTN UBE2A 25348397 N/A physical interaction ComPPI
TTN HEY1 25348397 N/A physical interaction ComPPI
TTN BRCA1 25348397 N/A physical interaction ComPPI
TTN OBSL1 20133654 20489725 24234451 25348397 physical association fluorescent resonance energy transfer,isothermal titration calorimetry,molecular sieving,pull down,x-ray crystallography,physical interaction ComPPI,IntAct
TTN MED19 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TTN MED10 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TTN MED29 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TTN MED26 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TTN ACTA2 24234451 25348397 9501083 physical association cosedimentation,cosedimentation in solution ComPPI,IntAct
TTN DFFA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TTN VDAC1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TTN DDX56 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TTN MCRS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TTN YWHAZ 20618440 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TTN FSTL1 20860622 24234451 25348397 physical association two hybrid ComPPI,IntAct
TTN MYC 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TTN DYSF 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
TTN ANKRD28 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN ASH2L 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN C1QTNF9 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN CCT6A 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN CLIP4 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN DNAJB5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN DNAJB6 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN ENO1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN ENO3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN ITGB1BP2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN JPH1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN LIMS1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN MAST2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN MYBPC2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN MYBPH 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN POMP 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN PYGM 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN RNF167 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN SGCG 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN ABLIM1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN ABLIM2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN ACTN4 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN ATP5F1D 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN CHD4 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN EXOSC10 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN FN1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN FNDC3B 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN GABARAP 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN HSPA1A 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN HSPA1B 25348397 N/A two hybrid fragment pooling approach ComPPI
TTN MYCBP2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN NEK9 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN NEO1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN PARD3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN PHGDH 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN RPL12 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN RYR1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN SF1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN TAB2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN TTC3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN UGP2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TTN ESR1 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
TTN ESR2 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
TTN SYNM 24234451 25348397 25447537 physical association two hybrid,pull down ComPPI,IntAct
TTN SUN2 22555292 24234451 25348397 association pull down ComPPI,IntAct
TTN HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TTN SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PKM TTN 25348397 N/A protein kinase assay ComPPI
YWHAQ TTN 25348397 N/A physical interaction ComPPI
TTN TTN 23414517 24234451 9804419 physical association two hybrid,x-ray crystallography,two hybrid fragment pooling approach IntAct
TTN CALM2 24234451 7607248 N/A cross-linking study IntAct
STK38L TTN 24234451 30108113 association pull down,proximity-dependent biotin identification IntAct
ERP29 TTN 24234451 30021884 physical association cross-linking study IntAct
STT3B TTN 24234451 30021884 physical association cross-linking study IntAct
CALU TTN 24234451 30021884 physical association cross-linking study IntAct
KTN1 TTN 24234451 30021884 physical association cross-linking study IntAct
HSPE1 TTN 24234451 30021884 physical association cross-linking study IntAct
NPM1 TTN 24234451 30021884 physical association cross-linking study IntAct
H2BC21 TTN 24234451 30021884 physical association cross-linking study IntAct
RSL1D1 TTN 24234451 30021884 physical association cross-linking study IntAct
TTN EBLN1 24234451 30021884 physical association cross-linking study IntAct
H1-2 TTN 24234451 30021884 physical association cross-linking study IntAct
H2BC9 TTN 24234451 30021884 physical association cross-linking study IntAct
HNRNPDL TTN 24234451 30021884 physical association cross-linking study IntAct
KRI1 TTN 24234451 30021884 physical association cross-linking study IntAct
HMGA1 TTN 24234451 30021884 physical association cross-linking study IntAct
H2BS1 TTN 24234451 30021884 physical association cross-linking study IntAct
KRT8 TTN 24234451 30021884 physical association cross-linking study IntAct
HNRNPF TTN 24234451 30021884 physical association cross-linking study IntAct
HNRNPA2B1 TTN 24234451 30021884 physical association cross-linking study IntAct
HNRNPA1L2 TTN 24234451 30021884 physical association cross-linking study IntAct
TARDBP TTN 24234451 30021884 physical association cross-linking study IntAct
PIK3R4 TTN 24234451 30021884 physical association cross-linking study IntAct
ATP5F1B TTN 24234451 30021884 physical association cross-linking study IntAct
H2AC4 TTN 24234451 30021884 physical association cross-linking study IntAct
H1-5 TTN 24234451 30021884 physical association cross-linking study IntAct
PRKACA TTN 19023132 27898060 N/A N/A OmniPath
CAMK2D TTN 20149875 23220127 23764881 25637629 27898060 N/A N/A OmniPath

Visualization










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