GENE：LRRC8D
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LRRC8D |
| FullNmae | leucine rich repeat containing 8 VRAC subunit D |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16992 |
| EnsembleID | ENSG00000171492 |
| Uniprot | Q7L1W4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LRRC8D | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LRRC8D | GO:0001678,GO:0005225,GO:0005225,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0005886,GO:0005886,GO:0007165,GO:0015734,GO:0015810,GO:0016020,GO:0016020,GO:0034214,GO:0034702,GO:0071470,GO:0098656,GO:0098656 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LRRC8D | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | LRRC8D | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | LRRC8D | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | LRRC8D | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TFAP2C | LRRC8D | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | LRRC8D | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | LRRC8D | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | LRRC8D | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000031602A | LRRC8D | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003D5391 | LRRC8D | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000065D58 | LRRC8D | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | LRRC8D | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018C928 | LRRC8D | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | LRRC8D | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | LRRC8D | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000236310 | LRRC8D | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HNRNPL | LRRC8D | 25348397 | N/A | physical interaction | ComPPI |
| EXOSC4 | LRRC8D | 14525934 15231747 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| TRIM25 | LRRC8D | 25348397 | N/A | physical interaction | ComPPI |
| HTR3A | LRRC8D | 25348397 | N/A | physical interaction | ComPPI |
| LRRC8D | APP | 25348397 | N/A | physical interaction | ComPPI |
| LRRC8D | LRRC8B | 25348397 | N/A | physical interaction | ComPPI |
| LRRC8D | SLC17A2 | 25348397 | N/A | physical interaction | ComPPI |
| LRRC8D | LRRC8A | 24234451 24790029 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |