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GENE：PARN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PARN
FullNmae poly(A)-specific ribonuclease
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8609
EnsembleID ENSG00000140694
Uniprot O95453

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PARN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PARN GO:0000184,GO:0000289,GO:0000495,GO:0003723,GO:0003723,GO:0003730,GO:0004518,GO:0004535,GO:0004535,GO:0004535,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0007292,GO:0009451,GO:0010587,GO:0016607,GO:0019901,GO:0032212,GO:0043169,GO:0046872,GO:0051973,GO:0070034,GO:0071051,GO:0090669,GO:0110008,GO:1904872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PARN hsa:5073 path:hsa03018 RNA degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PARN KHSRP 17177604 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PARN 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 PARN 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 PARN 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PARN 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 PARN 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 PARN 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 PARN 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PARN 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IGF1R PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PARN 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 PARN 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 PARN 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000007F792 PARN 23313552 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000076B539 PARN 23313552 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00005E6F45 PARN 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000041E11D PARN 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPKAPK2 PARN 22135298 phosphorylation N/A PhosphoSite
KHSRP PARN 25361965 interaction type N/A PTMCode2
PARN KHSRP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BYSL PARN 25348397 N/A physical interaction ComPPI
TP53BP1 PARN 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
PABPC1 PARN 17595167 24234451 25348397 physical association pull down ComPPI,IntAct
RPS6 PARN 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UPF2 PARN 25348397 N/A physical interaction ComPPI
SUMO2 PARN 25348397 N/A physical interaction ComPPI
MAPKAPK2 PARN 25348397 N/A physical interaction ComPPI
MDC1 PARN 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
UPF1 PARN 25348397 N/A physical interaction ComPPI
FOXA1 PARN 25348397 N/A physical interaction ComPPI
BARD1 PARN 20379136 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CSTF2 PARN 20379136 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CSTF1 PARN 25348397 N/A physical interaction ComPPI
NCBP1 PARN 20379136 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
PALS2 PARN 25348397 N/A physical interaction ComPPI
MPHOSPH6 PARN 14525934 15231747 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
UPF3A PARN 25348397 N/A physical interaction ComPPI
TEAD4 PARN 25348397 N/A physical interaction ComPPI
KHSRP PARN 14525934 15175153 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PARN SPATC1L 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PARN SIRT7 25348397 N/A physical interaction ComPPI
PARN H1-1 25348397 N/A physical interaction ComPPI
PARN CARNMT1 25348397 N/A physical interaction ComPPI
PARN PSG1 25348397 N/A physical interaction ComPPI
PARN TSR1 25348397 N/A physical interaction ComPPI
PARN TULP3 25348397 N/A physical interaction ComPPI
PARN ZC3HAV1 21876179 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPKAPK2 PARN 16964243 18669648 19690332 20932473 21173571 27898060 inhibition N/A OmniPath
PARN GADD45A 20932473 27898060 stimulant N/A OmniPath

Visualization










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