Gene Information gene info

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GENE：RFC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RFC4
FullNmae replication factor C subunit 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9972
EnsembleID ENSG00000163918
Uniprot P35249

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RFC4 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RFC4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RFC4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RFC4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RFC4 GO:0003677,GO:0003689,GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005663,GO:0005663,GO:0005663,GO:0006261,GO:0006261,GO:0006271,GO:0006281,GO:0016887,GO:0017116,GO:0031390,GO:0031391,GO:0032508,GO:1900264

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RFC4 hsa:5984 path:hsa03030 DNA replication - Homo sapiens (human)
RFC4 hsa:5984 path:hsa03410 Base excision repair - Homo sapiens (human)
RFC4 hsa:5984 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
RFC4 hsa:5984 path:hsa03430 Mismatch repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RFC4 RFC1 14624239 26192618 interaction type N/A ACSN
RFC4 RFC2 14624239 26192618 interaction type N/A ACSN
RFC4 RFC3 14624239 26192618 interaction type N/A ACSN
RFC4 RFC5 14624239 26192618 interaction type N/A ACSN
RFC4 PCNA 26192618 interaction type N/A ACSN
RNF2 RFC4 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
PPP2R1A RFC4 20005715 interaction type N/A PSP
YWHAZ RFC4 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
AR RFC4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 RFC4 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 RFC4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RFC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RFC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RFC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RFC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RFC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RFC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RFC4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 RFC4 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 RFC4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 RFC4 19074876 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
ATP6V0A1 RFC4 25361965 interaction type N/A PTMCode2
RFC4 ATP6V0A1 25361965 interaction type N/A PTMCode2
BRD2 RFC4 25361965 interaction type N/A PTMCode2
RFC4 BRD2 25361965 interaction type N/A PTMCode2
RFC4 POLE 25361965 interaction type N/A PTMCode2
POLE RFC4 25361965 interaction type N/A PTMCode2
RFC4 PCNA 25361965 interaction type N/A PTMCode2
PCNA RFC4 25361965 interaction type N/A PTMCode2
RFC4 RAD17 25361965 interaction type N/A PTMCode2
RAD17 RFC4 25361965 interaction type N/A PTMCode2
RFC4 RFC5 25361965 interaction type N/A PTMCode2
RFC5 RFC4 25361965 interaction type N/A PTMCode2
RFC2 RFC4 25361965 interaction type N/A PTMCode2
RFC4 RFC2 25361965 interaction type N/A PTMCode2
LIG1 RFC4 25361965 interaction type N/A PTMCode2
RFC4 LIG1 25361965 interaction type N/A PTMCode2
POLD1 RFC4 25361965 interaction type N/A PTMCode2
RFC4 POLD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 RFC4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L RFC4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
USP20 RFC4 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RARA RFC4 25348397 N/A physical interaction ComPPI
PCNA RFC4 10051561 12171929 14525934 24234451 25348397 26496610 association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TAF12 RFC4 25348397 N/A physical interaction ComPPI
EIF2B2 RFC4 25348397 N/A physical interaction ComPPI
GABARAPL2 RFC4 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NR5A1 RFC4 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KEAP1 RFC4 25348397 N/A physical interaction ComPPI
TAF9B RFC4 25348397 N/A physical interaction ComPPI
RPL10 RFC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOTCH1 RFC4 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NFATC1 RFC4 25348397 N/A physical interaction ComPPI
JUN RFC4 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
DHX9 RFC4 25348397 N/A physical interaction ComPPI
NELFB RFC4 25348397 N/A physical interaction ComPPI
PAXIP1 RFC4 25348397 N/A physical interaction ComPPI
YWHAZ RFC4 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
NTRK1 RFC4 25348397 N/A physical interaction ComPPI
RPA1 RFC4 25348397 N/A physical interaction ComPPI
RFC2 RFC4 14525934 15655353 24234451 25348397 8692848 9228079 9488738 association,physical association two hybrid,coimmunoprecipitation,cosedimentation in solution,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CHTF18 RFC4 11486023 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DSCC1 RFC4 25348397 N/A physical interaction ComPPI
DERPC RFC4 25348397 N/A physical interaction ComPPI
CHTF8 RFC4 25348397 N/A physical interaction ComPPI
MYC RFC4 17353931 21150319 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
HNRNPU RFC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD247 RFC4 24234451 24502978 25348397 association pull down ComPPI,IntAct
FSCN1 RFC4 20603015 24234451 25348397 association pull down ComPPI,IntAct
NFATC2 RFC4 25348397 N/A physical interaction ComPPI
EWSR1 RFC4 25348397 N/A physical interaction ComPPI
EPRS1 RFC4 25348397 N/A physical interaction ComPPI
RPA2 RFC4 25348397 N/A physical interaction ComPPI
RPA3 RFC4 25348397 N/A physical interaction ComPPI
QARS1 RFC4 25348397 N/A physical interaction ComPPI
ABCE1 RFC4 25348397 N/A physical interaction ComPPI
RPS6 RFC4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EGFR RFC4 25348397 N/A physical interaction ComPPI
FKBP3 RFC4 25348397 N/A physical interaction ComPPI
RNF2 RFC4 25348397 N/A physical interaction ComPPI
YBX3 RFC4 25348397 N/A physical interaction ComPPI
TAF6 RFC4 25348397 N/A physical interaction ComPPI
NCSTN RFC4 25348397 N/A physical interaction ComPPI
EPHA4 RFC4 25348397 N/A physical interaction ComPPI
MDC1 RFC4 25348397 N/A physical interaction ComPPI
VCAM1 RFC4 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
PRKN RFC4 25348397 N/A physical interaction ComPPI
H3C1 RFC4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
IBTK RFC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK9 RFC4 25348397 N/A physical interaction ComPPI
TAF2 RFC4 25348397 N/A physical interaction ComPPI
FLII RFC4 25348397 N/A physical interaction ComPPI
DDX1 RFC4 25348397 N/A physical interaction ComPPI
RFC5 RFC4 14525934 16189514 24234451 25348397 25416956 30021884 8692848 9228079 9488738 association,physical association two hybrid,cross-linking study,experimental interaction detection,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
RNF41 RFC4 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NOP56 RFC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRE11 RFC4 25348397 N/A physical interaction ComPPI
ILF2 RFC4 25348397 N/A physical interaction ComPPI
CDK4 RFC4 10353443 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RFC4 RFC3 14525934 24234451 25348397 8692848 9488738 association,physical association experimental interaction detection,pull down,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
RFC4 BRD4 12192049 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RFC4 RAD17 11907025 14525934 14624239 24234451 25348397 association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
RFC4 RFC1 24234451 25348397 9488738 association,physical association cosedimentation in solution,pull down,physical interaction ComPPI,IntAct
RFC4 UIMC1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RFC4 RUVBL2 25348397 N/A physical interaction ComPPI
RFC4 MEPCE 25348397 N/A physical interaction ComPPI
RFC4 RPAP2 25348397 N/A physical interaction ComPPI
RFC4 PMS1 25348397 N/A physical interaction ComPPI
RFC4 PML 25348397 N/A physical interaction ComPPI
RFC4 FAN1 25348397 N/A physical interaction ComPPI
RFC4 ATAD5 25348397 N/A physical interaction ComPPI
RFC4 PIDD1 25348397 N/A physical interaction ComPPI
RFC4 SMARCAD1 25348397 N/A physical interaction ComPPI
RFC4 HDGF 21907836 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RFC4 PRAME 25348397 N/A physical interaction ComPPI
RFC4 MCM3 25348397 N/A physical interaction ComPPI
RFC4 FN1 25348397 N/A physical interaction ComPPI
RFC4 MPG 25348397 N/A physical interaction ComPPI
RFC4 TARDBP 25348397 N/A physical interaction ComPPI
RFC4 ABCF1 25348397 N/A physical interaction ComPPI
RFC4 HNRNPM 25348397 N/A physical interaction ComPPI
RFC4 IGF2BP3 25348397 N/A physical interaction ComPPI
RFC4 NMT1 25348397 N/A physical interaction ComPPI
RFC4 RTCB 25348397 N/A physical interaction ComPPI
RFC4 DIMT1 25348397 N/A physical interaction ComPPI
RFC4 EDC4 25348397 N/A physical interaction ComPPI
RFC4 EIF2B3 25348397 N/A physical interaction ComPPI
RFC4 RPL26L1 25348397 N/A physical interaction ComPPI
RFC4 TP53 25348397 N/A physical interaction ComPPI
RFC4 BRCA1 25348397 N/A physical interaction ComPPI
RFC4 SETD3 25348397 N/A physical interaction ComPPI
RFC4 TRIM33 25348397 N/A physical interaction ComPPI
RFC4 ZNF746 25348397 N/A physical interaction ComPPI
RFC4 RAD1 25348397 N/A physical interaction ComPPI
RFC4 IL13RA2 25348397 N/A physical interaction ComPPI
RFC4 CD58 25348397 N/A physical interaction ComPPI
RFC4 NEURL4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RFC4 FBXO45 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RFC4 G3BP1 25348397 N/A physical interaction ComPPI
RFC4 TES 25348397 N/A physical interaction ComPPI
RFC4 MCM9 25348397 N/A physical interaction ComPPI
RFC4 ESR2 21182203 24234451 25348397 association cosedimentation through density gradient ComPPI,IntAct
RFC4 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
RFC4 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
RTRAF RFC4 25348397 N/A physical interaction ComPPI
DSOR1 RFC4 25348397 N/A physical interaction ComPPI
HDAC1 RFC4 12045192 14525934 N/A experimental interaction detection HPRD
TANK RFC4 24234451 30561431 association virotrap IntAct
L1TD1 RFC4 24234451 25702638 association anti bait coimmunoprecipitation IntAct

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