GENE：SH2B3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SH2B3 |
| FullNmae | SH2B adaptor protein 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29605 |
| EnsembleID | ENSG00000111252 |
| Uniprot | Q9UQQ2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SH2B3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SH2B3 | GO:0001780,GO:0005068,GO:0005173,GO:0005515,GO:0005829,GO:0005886,GO:0007169,GO:0008285,GO:0030159,GO:0035162,GO:0035556,GO:0035702,GO:0035855,GO:0036016,GO:0038163,GO:0038163,GO:0038163,GO:0043409,GO:0046426,GO:0048821,GO:0051898,GO:0060218,GO:0060761,GO:0070100,GO:0090331,GO:1900235,GO:1904893,GO:1990782,GO:1990869 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SH2B3 | hsa:10019 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SH2B3 | ERBB2 | 20005715 | interaction type | N/A | PSP,SignaLink |
| SH2B3 | LCK | 20005715 | interaction type | N/A | PSP,SignaLink |
| SH2B3 | PLCG1 | 20005715 | interaction type | N/A | PSP,SignaLink |
| SH2B3 | CD247 | 20005715 | interaction type | N/A | PSP |
| SH2B3 | ZAP70 | 20005715 | interaction type | N/A | PSP,SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SH2B3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | SH2B3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | SH2B3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | SH2B3 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | SH2B3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | SH2B3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | SH2B3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | SH2B3 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | SH2B3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | SH2B3 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002152A8 | SH2B3 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000F31F4 | SH2B3 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | SH2B3 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | SH2B3 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000070B1D | SH2B3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000101787 | SH2B3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FB065 | SH2B3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020CEC2 | SH2B3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D814 | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CAE0C | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008B558 | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A052 | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045147B | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E226A | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000044FD7 | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000057A7C | SH2B3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LCK | SH2B3 | 25361965 | interaction type | N/A | PTMCode2 |
| SH2B3 | LCK | 25361965 | interaction type | N/A | PTMCode2 |
| KIT | SH2B3 | 25361965 | interaction type | N/A | PTMCode2 |
| SH2B3 | KIT | 25361965 | interaction type | N/A | PTMCode2 |
| GRB2 | SH2B3 | 25361965 | interaction type | N/A | PTMCode2 |
| SH2B3 | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
| SH2B3 | CD247 | 25361965 | interaction type | N/A | PTMCode2 |
| CD247 | SH2B3 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ERBB2 | SH2B3 | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| KIT | SH2B3 | 11805142 14525934 24234451 24728074 25348397 | N/A | experimental interaction detection,fluorescence polarization spectroscopy,in vitro | ComPPI,HPRD,IntAct |
| SH2B3 | ZAP70 | 14525934 25348397 9169414 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SH2B3 | CD247 | 10799879 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SH2B3 | GRB2 | 14525934 25348397 27898060 8649391 8995445 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| SH2B3 | FLNA | 11163396 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| SH2B3 | LCK | 10799879 14525934 25348397 9169414 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| SH2B3 | PLCG1 | 25348397 | N/A | physical interaction | ComPPI |
| SH2B3 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| SH2B3 | EGFR | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| SH2B3 | ERBB3 | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| SH2B3 | TNS2 | 25348397 | N/A | physical interaction | ComPPI |
| SH2B3 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
| SH2B3 | HAVCR2 | 24234451 25348397 26492563 | association | pull down | ComPPI,IntAct |
| SH2B3 | SH2B3 | 14525934 8995445 | N/A | experimental interaction detection | HPRD |
| LCK | SH2B3 | 10799879 27898060 9169414 | stimulant | N/A | OmniPath |
| ZAP70 | SH2B3 | 27898060 9169414 | stimulant | N/A | OmniPath |