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GENE：DGKA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DGKA
FullNmae diacylglycerol kinase alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2849
EnsembleID ENSG00000065357
Uniprot P23743

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DGKA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DGKA GO:0004143,GO:0004143,GO:0004143,GO:0005509,GO:0005524,GO:0005543,GO:0005829,GO:0005886,GO:0005886,GO:0006654,GO:0007205,GO:0008289,GO:0016020,GO:0016301,GO:0030168,GO:0035556,GO:0046339,GO:0046339,GO:0046486,GO:0046834,GO:0046834

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DGKA hsa:1606 path:hsa00561 Glycerolipid metabolism - Homo sapiens (human)
DGKA hsa:1606 path:hsa00564 Glycerophospholipid metabolism - Homo sapiens (human)
DGKA hsa:1606 path:hsa01100 Metabolic pathways - Homo sapiens (human)
DGKA hsa:1606 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
DGKA hsa:1606 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
DGKA hsa:1606 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD2 DGKA 18729074 23180781 physical association tandem affinity purification InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 DGKA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 DGKA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C DGKA 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 DGKA 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DGKA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DGKA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DGKA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DGKA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DGKA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 DGKA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE DGKA 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SRC DGKA 22135298 phosphorylation N/A PhosphoSite
LCK DGKA 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SRC DGKA 14525934 15122338 17700527 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD2 DGKA 25348397 N/A physical interaction,tandem affinity purification ComPPI
SREK1 DGKA 14525934 14559993 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
ORC5 DGKA 25348397 N/A physical interaction ComPPI
IL21 DGKA 14525934 24234451 25241761 25348397 27898060 8626603 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct,OmniPath
FUS DGKA 25348397 N/A physical interaction ComPPI
SRC DGKA 15122338 17700527 27898060 stimulant N/A OmniPath

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