GENE:RND3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RND3 |
| FullNmae | Rho family GTPase 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:671 |
| EnsembleID | ENSG00000115963 |
| Uniprot | P61587 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RND3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RND3 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RND3 | GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0005886,GO:0005925,GO:0007015,GO:0007155,GO:0007165,GO:0007264,GO:0016477,GO:0019901,GO:0030036 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | RND3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | RND3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | RND3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | RND3 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | RND3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TLE5 | RND3 | 23546594 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXD3 | RND3 | 21478267 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002075FA | RND3 | 22132820 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS000012A1DD | RND3 | 20683643 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS000012A1DD | RND3 | 20683643 24151081 24667864 25416803 26254780 26935796 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00002075FA | RND3 | 22132820 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00004505E4 | RND3 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000122ED0 | RND3 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000DDD35 | RND3 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000065D58 | RND3 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000171525 | RND3 | 23821457 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000039E1E1 | RND3 | 25416803 25950430 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CPLANE2 | RND3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ROCK1 | RND3 | 12773565 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| ARHGAP5 | RND3 | 12842009 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| MAML1 | RND3 | 25348397 | N/A | physical interaction | ComPPI |
| FBXW7 | RND3 | 25348397 | N/A | physical interaction | ComPPI |
| NOTCH1 | RND3 | 25348397 | N/A | physical interaction | ComPPI |
| UBXN11 | RND3 | 11940653 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| CIT | RND3 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAB | RND3 | 23622247 24234451 25348397 | N/A | pull down | ComPPI,IntAct |
| YWHAZ | RND3 | 23622247 24234451 25348397 | N/A | isothermal titration calorimetry,pull down,surface plasmon resonance,x-ray crystallography | ComPPI,IntAct |
| RGS14 | RND3 | 25348397 | N/A | physical interaction | ComPPI |
| SFN | RND3 | 15778465 24234451 25348397 | physical association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| SKP2 | RND3 | 24045951 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| ARHGAP35 | RND3 | 25348397 | N/A | physical interaction | ComPPI |
| PLXNB1 | RND3 | 14732713 24234451 25348397 | physical association | affinity chromatography technology,physical interaction,affinity technology | ComPPI,IntAct |
| RND3 | PLEKHG5 | 25348397 | N/A | physical interaction | ComPPI |
| RND3 | RBPJ | 25348397 | N/A | physical interaction | ComPPI |
| RND3 | C14ORF119 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ROCK1 | RND3 | 12773565 15775972 27898060 | stimulant | N/A | OmniPath |
| PRKCZ | RND3 | 23622247 27898060 | N/A | N/A | OmniPath |
