GENE：CACNA1C
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CACNA1C |
| FullNmae | calcium voltage-gated channel subunit alpha1 C |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1390 |
| EnsembleID | ENSG00000151067 |
| Uniprot | Q13936 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CACNA1C | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CACNA1C | GO:0002520,GO:0005245,GO:0005245,GO:0005515,GO:0005516,GO:0005737,GO:0005886,GO:0005886,GO:0005886,GO:0005891,GO:0005891,GO:0007204,GO:0007507,GO:0008331,GO:0008331,GO:0008331,GO:0010881,GO:0010881,GO:0014069,GO:0016020,GO:0030018,GO:0030425,GO:0035115,GO:0035585,GO:0043010,GO:0043204,GO:0045762,GO:0046872,GO:0051393,GO:0060402,GO:0060402,GO:0061337,GO:0061577,GO:0061577,GO:0070588,GO:0070588,GO:0086002,GO:0086007,GO:0086012,GO:0086045,GO:0086056,GO:0086064,GO:0086091,GO:0098703,GO:0098839,GO:0098911,GO:0098912,GO:1990454 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CACNA1C | hsa:775 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04713 | Circadian entrainment - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04720 | Long-term potentiation - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04727 | GABAergic synapse - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04742 | Taste transduction - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04911 | Insulin secretion - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04924 | Renin secretion - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04929 | GnRH secretion - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa05412 | Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human) |
| CACNA1C | hsa:775 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CACNA1C | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | CACNA1C | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | CACNA1C | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | CACNA1C | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | CACNA1C | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | CACNA1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003E226A | CACNA1C | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000044FD7 | CACNA1C | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | CACNA1C | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E5ECC | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000014F13C | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000279B6F | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005BB0FD | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000035AC91 | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002367FA | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003EB4CF | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002394F5 | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F373E | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000027F5F3 | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045ED38 | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000759B6A | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB0E | CACNA1C | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076995 | CACNA1C | 25416803 27341015 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000034979B | CACNA1C | 25416803 27545043 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRC | CACNA1C | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKD1 | CACNA1C | 22135298 | phosphorylation | N/A | PhosphoSite |
| CACNA1C | BIN1 | 25361965 | interaction type | N/A | PTMCode2 |
| BIN1 | CACNA1C | 25361965 | interaction type | N/A | PTMCode2 |
| CALM1 | CACNA1C | 25361965 | interaction type | N/A | PTMCode2 |
| CACNA1C | CALM1 | 25361965 | interaction type | N/A | PTMCode2 |
| CALM3 | CACNA1C | 25361965 | interaction type | N/A | PTMCode2 |
| CACNA1C | CALM3 | 25361965 | interaction type | N/A | PTMCode2 |
| CALM2 | CACNA1C | 25361965 | interaction type | N/A | PTMCode2 |
| CACNA1C | CALM2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VCP | CACNA1C | 25348397 | N/A | physical interaction | ComPPI |
| PCBD1 | CACNA1C | 25348397 | N/A | physical interaction | ComPPI |
| CALM1 | CACNA1C | 25348397 | N/A | molecular sieving,pull down,x-ray crystallography,physical interaction,physical interaction | ComPPI |
| COPS5 | CACNA1C | 25348397 | N/A | physical interaction | ComPPI |
| HDAC4 | CACNA1C | 25348397 | N/A | physical interaction | ComPPI |
| PRKACA | CACNA1C | 25348397 | N/A | in vitro,in vivo | ComPPI |
| RYR2 | CACNA1C | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| PPM1A | CACNA1C | 25348397 | N/A | in vitro,in vivo | ComPPI |
| HNRNPL | CACNA1C | 25348397 | N/A | physical interaction | ComPPI |
| RIMS1 | CACNA1C | 11438519 25348397 27898060 | N/A | in vitro | ComPPI,OmniPath |
| SRI | CACNA1C | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| BIN1 | CACNA1C | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| CUL1 | CACNA1C | 25348397 | N/A | physical interaction | ComPPI |
| SIRT1 | CACNA1C | 25348397 | N/A | pull down,physical interaction | ComPPI |
| CAND1 | CACNA1C | 25348397 | N/A | physical interaction | ComPPI |
| CABP1 | CACNA1C | 15140941 21134641 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation,isothermal titration calorimetry,pull down,physical interaction,in vitro,in vivo | ComPPI,IntAct,OmniPath |
| CACNB3 | CACNA1C | 18535142 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction,in vitro | ComPPI,IntAct |
| DERL1 | CACNA1C | 25348397 | N/A | physical interaction | ComPPI |
| CACNA1C | GNB1 | 25348397 | N/A | two hybrid | ComPPI |
| CACNA1C | TRIM13 | 25348397 | N/A | physical interaction | ComPPI |
| CACNA1C | CACNB2 | 25348397 | N/A | anti tag coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI |
| CACNA1C | CACNB1 | 25348397 | N/A | anti tag coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI |
| CALM2 | CACNA1C | 15140941 16299511 16338416 19279214 20953164 24234451 | physical association | cosedimentation in solution,isothermal titration calorimetry,molecular sieving,pull down,x-ray crystallography,ion exchange chromatography | IntAct |
| SRC | CACNA1C | 12850569 17942635 27898060 | stimulant | N/A | OmniPath |
| SYT1 | CACNA1C | 12645522 27898060 | stimulant | N/A | OmniPath |
| PRKACA | CACNA1C | 10514522 10984483 2174428 27898060 7621818 8612821 8664319 9247274 | inhibition,stimulant | N/A | OmniPath |
| PRKCA | CACNA1C | 11035786 27898060 | inhibition | N/A | OmniPath |
| PRKD1 | CACNA1C | 22100296 22310722 27898060 | stimulant | N/A | OmniPath |
| FYN | CACNA1C | 12850569 27898060 | stimulant | N/A | OmniPath |
| PPP2R5C | CACNA1C | 10984483 27898060 | stimulant | N/A | OmniPath |