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GENE：EYA4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EYA4
FullNmae EYA transcriptional coactivator and phosphatase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3522
EnsembleID ENSG00000112319
Uniprot O95677

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EYA4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EYA4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EYA4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
EYA4 GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0006281,GO:0006325,GO:0007601,GO:0009653,GO:0030154,GO:0045739,GO:0046872,GO:0048839,GO:0048856,GO:2001240

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR EYA4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F1 EYA4 12629508 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 EYA4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 EYA4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EYA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EYA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EYA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EYA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EYA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EYA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF EYA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 EYA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 EYA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004DA9DB EYA4 20827281 rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000184017 EYA4 20827281 rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000330617 EYA4 20827281 rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004DA9DB EYA4 20827281 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000330617 EYA4 20827281 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000184017 EYA4 20827281 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000521626 EYA4 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS0000028BB8 EYA4 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00003380CC EYA4 17612493 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
SIX1 EYA4 25361965 interaction type N/A PTMCode2
EYA4 SIX1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPK1IP1L EYA4 25348397 N/A physical interaction ComPPI
BAG3 EYA4 25348397 N/A physical interaction ComPPI
UBE2D2 EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PKP2 EYA4 25348397 N/A physical interaction ComPPI
PLEC EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ERC1 EYA4 25348397 N/A physical interaction ComPPI
RPA2 EYA4 25348397 N/A physical interaction ComPPI
RPA3 EYA4 25348397 N/A physical interaction ComPPI
SUPT5H EYA4 25348397 N/A physical interaction ComPPI
SIX1 EYA4 14525934 15492887 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
DVL3 EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PFDN2 EYA4 25348397 N/A physical interaction ComPPI
SIX2 EYA4 25348397 N/A physical interaction ComPPI
SEC24B EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SIX4 EYA4 25348397 N/A physical interaction ComPPI
HELZ EYA4 25348397 N/A physical interaction ComPPI
CCDC88A EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DCTPP1 EYA4 25348397 N/A physical interaction ComPPI
URGCP EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ERBB3 EYA4 25348397 N/A physical interaction ComPPI
AATK EYA4 25348397 N/A physical interaction ComPPI
LUZP1 EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SLC25A15 EYA4 25348397 N/A physical interaction ComPPI
FOXJ2 EYA4 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SOAT1 EYA4 25348397 N/A physical interaction ComPPI
DDI2 EYA4 25348397 N/A physical interaction ComPPI
SCO2 EYA4 25348397 N/A physical interaction ComPPI
AAK1 EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EOGT EYA4 25348397 N/A physical interaction ComPPI
PPIP5K2 EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GLO1 EYA4 25348397 N/A physical interaction ComPPI
QSER1 EYA4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COQ5 EYA4 25348397 N/A physical interaction ComPPI
EYA4 SCO1 25348397 N/A physical interaction ComPPI

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