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GENE：MBD4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MBD4
FullNmae methyl-CpG binding domain 4, DNA glycosylase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6919
EnsembleID ENSG00000129071
Uniprot O95243

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MBD4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MBD4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MBD4 GO:0003677,GO:0003696,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0008263,GO:0016607,GO:0019104,GO:0032355,GO:0045008

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MBD4 hsa:8930 path:hsa03410 Base excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR MBD4 17483314 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 MBD4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MBD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MBD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MBD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MBD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MBD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MBD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC MBD4 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 MBD4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002394F5 MBD4 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075D15B MBD4 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 MBD4 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 MBD4 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 MBD4 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D MBD4 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 MBD4 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 MBD4 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C MBD4 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC379 MBD4 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 MBD4 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB MBD4 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C MBD4 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 MBD4 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000050CCE0 MBD4 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 MBD4 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075D860 MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002971AB MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039A052 MBD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 MBD4 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA MBD4 22135298 phosphorylation N/A PhosphoSite
MBD4 FADD 25361965 interaction type N/A PTMCode2
FADD MBD4 25361965 interaction type N/A PTMCode2
MBD4 DNMT3B 25361965 interaction type N/A PTMCode2
DNMT3B MBD4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
USP7 MBD4 25348397 N/A physical interaction ComPPI
APC MBD4 25348397 N/A physical interaction ComPPI
SIN3A MBD4 25348397 N/A physical interaction ComPPI
FADD MBD4 12702765 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
KIF20A MBD4 25348397 N/A physical interaction ComPPI
SUV39H1 MBD4 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HTT MBD4 23275563 24234451 25348397 physical association physical interaction,two hybrid prey pooling approach ComPPI,IntAct
DNMT3B MBD4 25348397 N/A physical interaction ComPPI
KDM1A MBD4 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRIM27 MBD4 17049487 21516116 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
MLH1 MBD4 10097147 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
FAS MBD4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MBD4 CSNK2B 14525934 14667819 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MBD4 HDAC1 25348397 N/A physical interaction ComPPI
MBD4 CDCA2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MBD4 SHMT2 25348397 N/A physical interaction ComPPI
MBD4 MOV10 25348397 N/A physical interaction ComPPI
MBD4 NXF1 25348397 N/A physical interaction ComPPI
MBD4 UHRF1 25348397 N/A physical interaction ComPPI
PSMD1 MBD4 24234451 30021884 physical association cross-linking study IntAct
PRKCA MBD4 19829383 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009AE403 MBD4 27087310 direct interaction,inhibition N/A NPInter

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