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GENE：NECTIN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NECTIN2
FullNmae nectin cell adhesion molecule 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9707
EnsembleID ENSG00000130202
Uniprot Q92692

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NECTIN2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NECTIN2 GO:0001618,GO:0001675,GO:0002860,GO:0002860,GO:0002891,GO:0002891,GO:0005515,GO:0005886,GO:0005886,GO:0005911,GO:0005915,GO:0005925,GO:0007010,GO:0007156,GO:0007156,GO:0007286,GO:0007289,GO:0009566,GO:0009986,GO:0015026,GO:0016020,GO:0019064,GO:0019064,GO:0030382,GO:0032990,GO:0033005,GO:0033005,GO:0042271,GO:0042271,GO:0042802,GO:0042803,GO:0043296,GO:0044291,GO:0044406,GO:0044782,GO:0045954,GO:0046596,GO:0046596,GO:0046718,GO:0046814,GO:0046814,GO:0050839,GO:0050839,GO:0050862,GO:0050862,GO:0051649,GO:0051654,GO:0060370,GO:0060370,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NECTIN2 hsa:5819 path:hsa03266 Virion - Herpesvirus - Homo sapiens (human)
NECTIN2 hsa:5819 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
NECTIN2 hsa:5819 path:hsa04520 Adherens junction - Homo sapiens (human)
NECTIN2 hsa:5819 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NECTIN2 PTPN11 12913096 19098271 22285893 26192618 26755705 interaction type N/A ACSN
NECTIN2 PTPN6 12913096 19098271 22285893 26192618 26755705 interaction type N/A ACSN
NECTIN2 TIGIT 12913096 19098271 22285893 26192618 26755705 interaction type N/A ACSN
NECTIN2 CD226 12913096 19098271 22285893 26192618 26755705 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
GATA2 NECTIN2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 NECTIN2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NECTIN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NECTIN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NECTIN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NECTIN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NECTIN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NECTIN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NECTIN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NECTIN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NECTIN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 NECTIN2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00003CF1AD NECTIN2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
KRTAP10-5 NECTIN2 24234451 25348397 25416956 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP5-9 NECTIN2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-1 NECTIN2 25348397 N/A two hybrid,physical interaction ComPPI
KRTAP10-8 NECTIN2 25348397 N/A two hybrid ComPPI
KRTAP12-2 NECTIN2 25348397 N/A two hybrid ComPPI
KRTAP10-7 NECTIN2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NECTIN2 MDFI 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
NECTIN2 NECTIN3 12011057 14525934 21982860 23758976 24234451 25348397 physical association experimental interaction detection,protein array,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
NECTIN2 CD226 12913096 14525934 15536144 21982860 24234451 25348397 physical association experimental interaction detection,protein array,physical interaction,in vivo ComPPI,HPRD,IntAct
NECTIN2 ATP5MF 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NECTIN2 PICK1 14525934 15811349 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NECTIN2 AFDN 23750010 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NECTIN2 MAPK6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NECTIN2 NECTIN4 21982860 24234451 25348397 physical association protein array,physical interaction ComPPI,IntAct
NECTIN2 TIGIT 21982860 24234451 25348397 27978489 28515320 physical association molecular sieving,protein array,surface plasmon resonance,x-ray crystallography,physical interaction ComPPI,IntAct
NECTIN2 DUS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NECTIN2 LYRM4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NECTIN2 SIAH1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NECTIN2 KRTAP10-3 25348397 N/A physical interaction ComPPI
NECTIN2 NOTCH2NLA 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NECTIN2 CEACAM21 25348397 N/A physical interaction ComPPI
NECTIN2 FUT9 25348397 N/A physical interaction ComPPI
NECTIN2 TBC1D22A 25348397 N/A physical interaction ComPPI
NECTIN2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NECTIN2 TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NECTIN2 CDH1 25348397 N/A physical interaction ComPPI
NECTIN2 CTDSPL 25348397 N/A physical interaction ComPPI
NECTIN2 TMEM30B 25348397 N/A physical interaction ComPPI
NECTIN2 RARS1 25348397 N/A physical interaction ComPPI
NECTIN2 SYPL2 25348397 N/A physical interaction ComPPI
NECTIN2 BTBD1 25348397 N/A physical interaction ComPPI
NECTIN2 SERPINA12 25348397 N/A physical interaction ComPPI
NECTIN2 PANK2 25348397 N/A physical interaction ComPPI
NECTIN2 ALOXE3 25348397 N/A physical interaction ComPPI
NECTIN2 APOD 25348397 N/A physical interaction ComPPI
NECTIN2 AKAP12 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NECTIN2 HNRNPL 25348397 N/A physical interaction ComPPI
NECTIN2 DBN1 23750010 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct
NECTIN2 CYSRT1 25348397 N/A two hybrid ComPPI
NECTIN2 KRTAP1-1 25348397 N/A two hybrid ComPPI
NECTIN2 TGM1 25348397 N/A two hybrid ComPPI
NECTIN2 LCE1C 25348397 N/A two hybrid ComPPI
NECTIN2 LCE5A 25348397 N/A two hybrid ComPPI
NECTIN2 LCE2B 25348397 N/A two hybrid ComPPI
NECTIN2 LCE2C 25348397 N/A two hybrid ComPPI
NECTIN2 NR4A3 25348397 N/A two hybrid ComPPI
NECTIN2 P4HB 25348397 N/A two hybrid ComPPI
NECTIN2 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
USP53 NECTIN2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NECTIN2 NECTIN2 14525934 21982860 22902367 22927415 23758976 24234451 28515320 9845526 physical association cosedimentation in solution,experimental interaction detection,molecular sieving,protein array,surface plasmon resonance,x-ray crystallography,enzyme linked immunosorbent assay HPRD,IntAct
NECTIN2 GP1BA 24234451 29997244 physical association luminescence based mammalian interactome mapping IntAct
DNAJC5 NECTIN2 24234451 29997244 physical association bioluminescence resonance energy transfer,luminescence based mammalian interactome mapping IntAct
NECTIN2 SSH1 24234451 30021884 physical association cross-linking study IntAct
AFDN NECTIN2 10225955 10733589 15811349 23750010 27898060 N/A N/A OmniPath

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