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GENE：RASGRP3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RASGRP3
FullNmae RAS guanyl releasing protein 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14545
EnsembleID ENSG00000152689
Uniprot Q8IV61

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RASGRP3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RASGRP3 GO:0000165,GO:0005085,GO:0005085,GO:0005096,GO:0005509,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0007264,GO:0007265,GO:0007265,GO:0019900,GO:0019992,GO:0031267,GO:0032045,GO:0043547,GO:0048471

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RASGRP3 hsa:25780 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RASGRP3 hsa:25780 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
RASGRP3 hsa:25780 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
RASGRP3 hsa:25780 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
RASGRP3 hsa:25780 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP RASGRP3 21832049 23180781 physical association protein array InnateDB
NRAS RASGRP3 10777492 10835426 10934204 11221888 17283063 29145629 enzymatic reaction inferred by curator Reactome
KRAS RASGRP3 10777492 10835426 10934204 11221888 17283063 29145629 enzymatic reaction inferred by curator Reactome
HRAS RASGRP3 10777492 10835426 10934204 11221888 17283063 29145629 enzymatic reaction inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
AR RASGRP3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 RASGRP3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 RASGRP3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RASGRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RASGRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RASGRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RASGRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RASGRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RASGRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RASGRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB5 RASGRP3 21132541 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D RASGRP3 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065D58 RASGRP3 22473208 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F RASGRP3 22473208 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 RASGRP3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 RASGRP3 22473208 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 RASGRP3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 RASGRP3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC RASGRP3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000019D79B RASGRP3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 RASGRP3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040780F RASGRP3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 RASGRP3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 RASGRP3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EBD4B RASGRP3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005651EE RASGRP3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002D349B RASGRP3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F RASGRP3 25416803 27505319 mrna cleavage,inhibition nucleotide sequence identification,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD RASGRP3 22135298 phosphorylation N/A PhosphoSite
PRKCQ RASGRP3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
DYNLL2 RASGRP3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRKCQ RASGRP3 12730099 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKCD RASGRP3 14525934 15213298 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKCE RASGRP3 25348397 N/A physical interaction ComPPI
PRKACA RASGRP3 25348397 N/A physical interaction ComPPI
PIK3CA RASGRP3 25348397 N/A physical interaction ComPPI
PRKCB RASGRP3 12730099 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RASGRP3 APP 25348397 N/A physical interaction ComPPI
RASGRP3 DGKI 25348397 N/A physical interaction ComPPI
RASGRP3 SULT1C2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RASGRP3 GET1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RASGRP3 HSD17B11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
YWHAQ RASGRP3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KHDRBS2 RASGRP3 27898060 9571195 9743338 N/A N/A OmniPath
PRKCA RASGRP3 12730099 15213298 27898060 stimulant N/A OmniPath
APP RASGRP3 21832049 27898060 N/A N/A OmniPath
RASGRP3 APP 21832049 27898060 N/A N/A OmniPath
RASGRP3 AKT1 14707121 27898060 stimulant N/A OmniPath
PRKCQ RASGRP3 12730099 15545601 15657177 27898060 stimulant N/A OmniPath
RASGRP3 NRAS 10934204 27898060 2833817 9582122 inhibition,stimulant N/A OmniPath
DOK1 RASGRP3 27898060 9008161 9233798 stimulant N/A OmniPath
EFNB2 RASGRP3 27898060 9233798 stimulant N/A OmniPath

Visualization










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