Gene Information gene info

GENE:TPM2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TPM2
FullNmae tropomyosin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12011
EnsembleID ENSG00000198467
Uniprot P07951

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TPM2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TPM2 GO:0003779,GO:0005829,GO:0005862,GO:0005884,GO:0006936,GO:0007015,GO:0008307,GO:0015629,GO:0042802,GO:0042803,GO:0043462,GO:0046982,GO:0051015,GO:0051015

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TPM2 hsa:7169 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
TPM2 hsa:7169 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
TPM2 hsa:7169 path:hsa04814 Motor proteins - Homo sapiens (human)
TPM2 hsa:7169 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
TPM2 hsa:7169 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TPM2 UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR TPM2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
MYC TPM2 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 TPM2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 TPM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000023F008 TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F1B8C TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000022AAA TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000519450 TPM2 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RRAD TPM2 25361965 interaction type N/A PTMCode2
TPM2 RRAD 25361965 interaction type N/A PTMCode2
PDLIM7 TPM2 25361965 interaction type N/A PTMCode2
TPM2 PDLIM7 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KANSL1 TPM2 25348397 N/A physical interaction ComPPI
S100A4 TPM2 14525934 25348397 8120097 N/A experimental interaction detection,in vitro ComPPI,HPRD
SKIL TPM2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
S100A2 TPM2 14525934 25348397 9092943 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PKIG TPM2 25348397 N/A physical interaction ComPPI
ACTB TPM2 14525934 25348397 9108196 N/A experimental interaction detection,in vivo ComPPI,HPRD
PPP1CB TPM2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK5R1 TPM2 25348397 N/A physical interaction ComPPI
PCGF2 TPM2 25348397 N/A physical interaction ComPPI
CPSF7 TPM2 25348397 N/A physical interaction ComPPI
TNNI1 TPM2 25348397 N/A physical interaction ComPPI
LGALS9C TPM2 25348397 N/A physical interaction ComPPI
MYH7 TPM2 25348397 N/A physical interaction ComPPI
SP1 TPM2 25348397 N/A physical interaction ComPPI
DSTN TPM2 25348397 N/A physical interaction ComPPI
PIK3CG TPM2 14525934 16094730 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPK3 TPM2 25348397 N/A physical interaction ComPPI
GRB2 TPM2 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN TPM2 14525934 1631061 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
TPM2 RRAD 14525934 25348397 27898060 8557685 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TPM2 PDLIM7 10359609 14525934 25348397 26496610 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TPM2 GRK2 14525934 16094730 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TPM2 TPM1 14525934 22939629 24234451 25348397 26186194 27898060 30021884 3857586 7568216 physical association cross-linking study,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct,OmniPath
TPM2 ACTA1 25348397 N/A physical interaction ComPPI
TPM2 LRRK2 25348397 N/A physical interaction ComPPI
TPM2 AKT1 20856200 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM2 TPM4 25348397 N/A physical interaction ComPPI
TPM2 AHCYL1 25348397 N/A physical interaction ComPPI
TPM2 TPM3 25348397 N/A physical interaction ComPPI
TPM2 STMN1 25348397 N/A physical interaction ComPPI
TPM2 SRXN1 25348397 N/A physical interaction ComPPI
TPM2 SF3B2 25348397 N/A physical interaction ComPPI
TPM2 DDB1 25348397 N/A physical interaction ComPPI
TPM2 NONO 25348397 N/A physical interaction ComPPI
TPM2 CORO1B 25348397 N/A physical interaction ComPPI
TPM2 SULT1A1 25348397 N/A physical interaction ComPPI
TPM2 STAM 25348397 N/A physical interaction ComPPI
TPM2 TAF15 25348397 N/A physical interaction ComPPI
TPM2 DYNC1H1 25348397 N/A physical interaction ComPPI
TPM2 DDX46 25348397 N/A physical interaction ComPPI
TPM2 DDX3X 25348397 N/A physical interaction ComPPI
TPM2 HECTD1 25348397 N/A physical interaction ComPPI
TPM2 RPA3 25348397 N/A physical interaction ComPPI
TPM2 RPA2 25348397 N/A physical interaction ComPPI
TPM2 MAGEA10 25348397 N/A physical interaction ComPPI
TPM2 FAM189B 25348397 N/A physical interaction ComPPI
TPM2 CFAP300 25348397 N/A physical interaction ComPPI
TPM2 ASPDH 25348397 N/A physical interaction ComPPI
TPM2 CIART 25348397 N/A physical interaction ComPPI
TPM2 ZNF250 25348397 N/A physical interaction ComPPI
TPM2 NEB 25348397 N/A physical interaction ComPPI
TPM2 ACTN1 25348397 N/A physical interaction ComPPI
TPM2 ACTN4 25348397 N/A physical interaction ComPPI
TPM2 CKMT1A 25348397 N/A physical interaction ComPPI
TPM2 PSMD5 25348397 N/A physical interaction ComPPI
TPM2 ACTN2 25348397 N/A physical interaction ComPPI
TPM2 ATP5PB 25348397 N/A physical interaction ComPPI
TPM2 BCAP31 25348397 N/A physical interaction ComPPI
TPM2 CAPZB 25348397 N/A physical interaction ComPPI
TPM2 CCAR1 25348397 N/A physical interaction ComPPI
TPM2 MYH3 25348397 N/A physical interaction ComPPI
TPM2 MYH6 25348397 N/A physical interaction ComPPI
TPM2 MYL6 25348397 N/A physical interaction ComPPI
TPM2 NDUFB10 25348397 N/A physical interaction ComPPI
TPM2 SSB 25348397 N/A physical interaction ComPPI
TPM2 UQCRC2 25348397 N/A physical interaction ComPPI
TPM2 ADD1 25348397 N/A physical interaction ComPPI
TPM2 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM2 CDK2 25348397 N/A physical interaction ComPPI
TPM2 FLNA 25348397 N/A physical interaction ComPPI
TPM2 MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM2 SYNPO 25348397 N/A physical interaction ComPPI
TPM2 ANLN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM2 MYO5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM2 MYO19 25348397 N/A physical interaction ComPPI
TPM2 MYO18A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM2 RBPJ 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
TPM2 RC3H1 25348397 N/A physical interaction ComPPI
TPM2 SLC25A48 25348397 N/A physical interaction ComPPI
TPM2 CFHR3 25348397 N/A physical interaction ComPPI
TPM2 TMEM205 25348397 N/A physical interaction ComPPI
TPM2 WAC 25348397 N/A physical interaction ComPPI
TPM2 ZNF22 25348397 N/A physical interaction ComPPI
TPM2 H1-6 25348397 N/A physical interaction ComPPI
TPM2 SINHCAF 25348397 N/A physical interaction ComPPI
TPM2 AKT2 25348397 N/A physical interaction ComPPI
TPM2 C1ORF43 25348397 N/A physical interaction ComPPI
TPM2 ZNF704 25348397 N/A physical interaction ComPPI
TPM2 SEMA6D 25348397 N/A physical interaction ComPPI
TPM2 ATAD1 25348397 N/A physical interaction ComPPI
TPM2 RRM2B 25348397 N/A physical interaction ComPPI
TPM2 CFAP97D1 25348397 N/A physical interaction ComPPI
TPM2 STOX1 25348397 N/A physical interaction ComPPI
TPM2 POC1B 25348397 N/A physical interaction ComPPI
TPM2 STK17B 25348397 N/A physical interaction ComPPI
TPM2 HAS3 25348397 N/A physical interaction ComPPI
TPM2 POTEB3 25348397 N/A physical interaction ComPPI
TPM2 RHOBTB2 25348397 N/A physical interaction ComPPI
TPM2 POF1B 25348397 N/A physical interaction ComPPI
TPM2 AGBL2 25348397 N/A physical interaction ComPPI
TPM2 SLC47A1 25348397 N/A physical interaction ComPPI
TPM2 YIPF1 25348397 N/A physical interaction ComPPI
TPM2 PDLIM5 25348397 N/A physical interaction ComPPI
TPM2 AKAP9 25348397 N/A physical interaction ComPPI
TPM2 NINL 25348397 N/A physical interaction ComPPI
TPM2 CCDC51 25348397 N/A physical interaction ComPPI
TPM2 SCG3 25348397 N/A physical interaction ComPPI
TPM2 TRIM25 25348397 N/A physical interaction ComPPI
TPM2 G3BP1 25348397 N/A physical interaction ComPPI
TPM2 CFTR 25348397 N/A physical interaction ComPPI
TPM2 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TPM2 EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TPM2 MAST2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TPM2 SNAPIN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RPA1 TPM2 25348397 N/A physical interaction ComPPI
SUB1 TPM2 25348397 N/A physical interaction ComPPI
IQGAP1 TPM2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEPTIN2 TPM2 25348397 N/A physical interaction ComPPI
TIMM44 TPM2 25348397 N/A physical interaction ComPPI
SLC4A1AP TPM2 25348397 N/A physical interaction ComPPI
COX4I1 TPM2 25348397 N/A physical interaction ComPPI
EBNA1BP2 TPM2 25348397 N/A physical interaction ComPPI
TPM2 TPM2 1304342 14525934 3857586 7568216 N/A experimental interaction detection HPRD
TPM2 CALR 24234451 30021884 physical association cross-linking study IntAct
PIK3CG TPM2 16094730 27898060 N/A N/A OmniPath

Visualization