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GENE：UBE2K

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UBE2K
FullNmae ubiquitin conjugating enzyme E2 K
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4914
EnsembleID ENSG00000078140
Uniprot P61086

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UBE2K immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UBE2K apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UBE2K apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
UBE2K GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006511,GO:0010800,GO:0010994,GO:0031625,GO:0032433,GO:0032434,GO:0034450,GO:0035458,GO:0043161,GO:0060340,GO:0061631,GO:0070936,GO:1903265

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UBE2K hsa:3093 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 UBE2K 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 UBE2K 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 UBE2K 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 UBE2K 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC UBE2K 21750653 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 UBE2K 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000021D7C8 UBE2K 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004719AB UBE2K 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000306C70 UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000038446A UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 UBE2K 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002CAE0C UBE2K 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA UBE2K 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 UBE2K 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000B59A2 UBE2K 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC UBE2K 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 UBE2K 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SUMO1 UBE2K 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I UBE2K 15723079 18691969 21098080 21139563 25348397 26344197 27898060 N/A physical interaction ComPPI,OmniPath
RNF183 UBE2K 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BAG3 UBE2K 25348397 N/A physical interaction ComPPI
RING1 UBE2K 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MKRN3 UBE2K 25348397 N/A physical interaction ComPPI
DDI1 UBE2K 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TXNDC17 UBE2K 25348397 N/A physical interaction ComPPI
BIRC8 UBE2K 25348397 N/A physical interaction ComPPI
RNF5 UBE2K 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PICK1 UBE2K 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
REL UBE2K 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RNF111 UBE2K 25348397 N/A physical interaction ComPPI
CBLC UBE2K 25348397 N/A physical interaction ComPPI
FZR1 UBE2K 25348397 N/A physical interaction ComPPI
UBE2D2 UBE2K 25348397 N/A physical interaction ComPPI
SIAH1 UBE2K 19549727 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBB UBE2K 25348397 N/A pull down,physical interaction,comigration in sds page,surface plasmon resonance array ComPPI
UBC UBE2K 11916981 16007098 16868077 20826778 21281599 22496338 23105008 24882218 24912152 25348397 25799589 27898060 9857030 N/A pull down,physical interaction,comigration in sds page,surface plasmon resonance array ComPPI,OmniPath
RPS27A UBE2K 25348397 N/A pull down,physical interaction,comigration in sds page,surface plasmon resonance array ComPPI
UBA52 UBE2K 25348397 N/A pull down,physical interaction,comigration in sds page,surface plasmon resonance array ComPPI
DLD UBE2K 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UBE2N UBE2K 25348397 N/A physical interaction ComPPI
PRPF40A UBE2K 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
WWP2 UBE2K 25348397 N/A physical interaction ComPPI
CDC6 UBE2K 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TXN UBE2K 25348397 N/A physical interaction ComPPI
HNRNPL UBE2K 25348397 N/A physical interaction ComPPI
UHRF2 UBE2K 25348397 N/A physical interaction ComPPI
RAB1A UBE2K 25348397 N/A physical interaction ComPPI
SDCBP UBE2K 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRIT1 UBE2K 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEDD4L UBE2K 17429078 22496338 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NEDD8 UBE2K 14525934 25348397 9857030 N/A experimental interaction detection,in vitro ComPPI,HPRD
MDM2 UBE2K 25348397 N/A physical interaction ComPPI
ITSN1 UBE2K 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ZDHHC17 UBE2K 24234451 24705354 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HTT UBE2K 14525934 17500595 23275563 24234451 25348397 27898060 8702625 9700202 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct,OmniPath
VHL UBE2K 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRIM63 UBE2K 25348397 N/A physical interaction ComPPI
RNF2 UBE2K 25348397 N/A physical interaction ComPPI
ITCH UBE2K 25348397 N/A physical interaction ComPPI
CCNB1 UBE2K 20965177 24234451 25348397 27898060 physical association pull down,physical interaction ComPPI,IntAct,OmniPath
UBE2K TRIM3 11513855 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
UBE2K PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UBE2K NFKB1 14525934 25348397 27898060 9535861 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
UBE2K DSTYK 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2K DDX58 25348397 N/A physical interaction ComPPI
UBE2K RNF125 19549727 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2K RNF138 19549727 24234451 25348397 25416956 27173435 association,physical association two hybrid,physical interaction,two hybrid array,tandem affinity purification,two hybrid prey pooling approach,validated two hybrid,inference by socio-affinity scoring ComPPI,IntAct
UBE2K BFAR 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2K UBOX5 25348397 N/A physical interaction ComPPI
UBE2K DTX3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2K MARCHF7 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2K TRIM27 24234451 25348397 27107012 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
UBE2K RNF185 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2K TRIM35 25348397 N/A physical interaction ComPPI
UBE2K BIRC7 25348397 N/A physical interaction ComPPI
UBE2K RNF4 25348397 N/A physical interaction ComPPI
UBE2K TRIM34 25348397 N/A physical interaction ComPPI
UBE2K RNF167 25348397 N/A physical interaction ComPPI
UBE2K TRAF7 25348397 N/A physical interaction ComPPI
UBE2K MKRN2 25348397 N/A physical interaction ComPPI
UBE2K RNF41 25348397 N/A physical interaction ComPPI
UBE2K MARCHF3 25348397 N/A physical interaction ComPPI
UBE2K RNF32 25348397 N/A physical interaction ComPPI
UBE2K RNF114 25348397 N/A physical interaction ComPPI
UBE2K LRSAM1 25348397 N/A physical interaction ComPPI
UBE2K DTX3L 25348397 N/A physical interaction ComPPI
UBE2K DZIP3 25348397 N/A physical interaction ComPPI
UBE2K MID1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2K TRIM39 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2K RNF144A 25348397 N/A physical interaction ComPPI
UBE2K TRIM2 25348397 N/A physical interaction ComPPI
UBE2K TRIM31 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2K TRIM5 25348397 N/A physical interaction ComPPI
UBE2K RBCK1 25348397 N/A physical interaction ComPPI
UBE2K DIABLO 20537984 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UBE2K BRCA1 25348397 N/A physical interaction ComPPI
UBE2K CASP12 25348397 N/A physical interaction ComPPI
UBE2K NUB1 25348397 N/A physical interaction ComPPI
UBE2K NXF1 25348397 N/A physical interaction ComPPI
UBE2K WDR1 25348397 N/A physical interaction ComPPI
UBE2K WDR61 25348397 N/A physical interaction ComPPI
UBE2K TYMS 25348397 N/A physical interaction ComPPI
UBE2K ANAPC11 25348397 N/A physical interaction ComPPI
UBE2K IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2K UBA1 17597759 2265617 25348397 27898060 8125920 9857030 N/A physical interaction ComPPI,OmniPath
UBE2K TP53 10634809 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
UBE2K PRRG4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2K MIPOL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2K AMFR 25348397 N/A physical interaction ComPPI
UBE2K BARD1 25348397 N/A physical interaction ComPPI
UBE2K SENP1 25348397 N/A physical interaction ComPPI
UBE2K MAP3K1 25348397 N/A physical interaction ComPPI
UBE2K HNRNPA1 25348397 N/A physical interaction ComPPI
UBE2K PEDS1 25348397 N/A physical interaction ComPPI
UBE2K UBE2V1 25348397 N/A physical interaction ComPPI
UBE2K RC3H2 25348397 N/A physical interaction ComPPI
UBE2K SMURF1 25348397 N/A physical interaction ComPPI
UBE2K CYHR1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
UBE2K ARL15 25348397 N/A physical interaction ComPPI
UBE2K USP1 25348397 N/A physical interaction ComPPI
UBE2K PRKN 25348397 N/A physical interaction ComPPI
UBE2K PJA1 25348397 N/A physical interaction ComPPI
UBE2K HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBE2K NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBE2K IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBE2K EXOSC7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2K CCNC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2K TSN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2K TRIM50 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2K PAX6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAIP UBE2K 25348397 N/A physical interaction ComPPI
TRIM43 UBE2K 25348397 N/A physical interaction ComPPI

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