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GENE：ADAM15

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ADAM15
FullNmae ADAM metallopeptidase domain 15
LocusType gene with protein product
Status Approved
HGNC_id HGNC:193
EnsembleID ENSG00000143537
Uniprot Q13444

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ADAM15 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ADAM15 GO:0001525,GO:0001669,GO:0001953,GO:0002418,GO:0004222,GO:0004222,GO:0005178,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005912,GO:0006508,GO:0007160,GO:0007229,GO:0007229,GO:0008237,GO:0008584,GO:0009986,GO:0017124,GO:0022617,GO:0030308,GO:0030336,GO:0030574,GO:0031514,GO:0042246,GO:0045087,GO:0045087,GO:0046872,GO:0060317,GO:0070062,GO:1900121,GO:1904628,GO:1990910

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SH3PXD2A ADAM15 18296648 23180781 physical association pull down InnateDB
GRB2 ADAM15 18296648 23180781 physical association pull down InnateDB
NCK1 ADAM15 18296648 23180781 physical association pull down InnateDB
SRC ADAM15 18296648 23180781 physical association pull down InnateDB
MAPK1 ADAM15 18296648 23180781 physical association pull down InnateDB
PTK6 ADAM15 18296648 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
FOXP3 ADAM15 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ADAM15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ADAM15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ADAM15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ADAM15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ADAM15 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000035CC3E ADAM15 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000B989F ADAM15 23806264 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
LCK ADAM15 22135298 phosphorylation N/A PhosphoSite
HCK ADAM15 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
RBPMS ADAM15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FHL3 ADAM15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MAD2L2 ADAM15 10531379 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
YES1 ADAM15 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
SH3GLB1 ADAM15 16374509 24234451 25348397 physical association filter binding,physical interaction ComPPI,IntAct
PACSIN3 ADAM15 10531379 14525934 16374509 24234451 25348397 physical association two hybrid,experimental interaction detection,filter binding,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SORBS3 ADAM15 14525934 16374509 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NUP62 ADAM15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SP4 ADAM15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SPAG5 ADAM15 10531379 24234451 25348397 physical association two hybrid ComPPI,IntAct
MAPK1 ADAM15 25348397 N/A physical interaction ComPPI
LYN ADAM15 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
SRC ADAM15 11741929 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,phage display,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
LCK ADAM15 11741929 14525934 16374509 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
NCK1 ADAM15 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
MAPK3 ADAM15 25348397 N/A physical interaction ComPPI
GRB2 ADAM15 11741929 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SORBS1 ADAM15 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,in vitro ComPPI,HPRD,IntAct
CANX ADAM15 24234451 25348397 29568061 association pull down ComPPI,IntAct
ITGB3 ADAM15 24234451 24789099 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
NPHP1 ADAM15 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,phage display,physical interaction,in vitro ComPPI,HPRD,IntAct
SORBS2 ADAM15 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
SNX9 ADAM15 10531379 14525934 16374509 24234451 25348397 physical association two hybrid,experimental interaction detection,filter binding,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
TIMP3 ADAM15 25348397 N/A tandem affinity purification ComPPI
ADAM15 SH3D19 14525934 15280379 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ADAM15 TRIP13 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ADAM15 SNX33 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,phage display,in vitro,in vivo ComPPI,HPRD,IntAct
ADAM15 SH3PXD2A 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,phage display,physical interaction,in vitro ComPPI,HPRD,IntAct
ADAM15 ARHGEF7 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
ADAM15 ARHGEF6 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
ADAM15 SH3RF3 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
ADAM15 SH3RF1 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,in vitro ComPPI,HPRD,IntAct
ADAM15 FYN 11741929 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
ADAM15 HCK 11741929 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
ADAM15 MAD2L1 25348397 N/A physical interaction ComPPI
ADAM15 SNX30 25348397 N/A physical interaction ComPPI
ADAM15 PTK6 25348397 N/A physical interaction ComPPI
ADAM15 FBXO6 25348397 N/A physical interaction ComPPI
ADAM15 IL4I1 25348397 N/A physical interaction ComPPI
ADAM15 BANP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ADAM15 ADAM33 25348397 N/A physical interaction ComPPI
ADAM15 TRIM25 25348397 N/A physical interaction ComPPI
ADAM15 ABL1 11741929 14525934 24234451 25348397 physical association experimental interaction detection,pull down ComPPI,HPRD,IntAct
ADAM15 ITGA5 24234451 24789099 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
ADAM15 CX3CL1 24234451 24789099 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
SH3GL2 ADAM15 10531379 14525934 16374509 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SRC ADAM15 11741929 16374509 18296648 19718658 27898060 N/A N/A OmniPath
ADAM15 SRC 11741929 16374509 18296648 19718658 27898060 N/A N/A OmniPath
LCK ADAM15 11741929 16374509 27898060 stimulant N/A OmniPath
HCK ADAM15 11741929 16374509 27898060 stimulant N/A OmniPath
ADAM15 GRB2 11741929 16374509 18296648 27898060 N/A N/A OmniPath
ADAM15 MAPK1 18296648 27898060 N/A N/A OmniPath
MAPK12 ADAM15 11741929 27898060 N/A N/A OmniPath
ADAM15 ITGB3 27898060 9516430 9914169 stimulant N/A OmniPath
ADAM15 ITGAV 27898060 9914169 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008BCE42 ADAM15 27087310 direct interaction,inhibition N/A NPInter
URS00009AF7FB ADAM15 27087310 direct interaction,inhibition N/A NPInter

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