GENE：COX7A2L
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | COX7A2L |
| FullNmae | cytochrome c oxidase subunit 7A2 like |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2289 |
| EnsembleID | ENSG00000115944 |
| Uniprot | O14548 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| COX7A2L | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| COX7A2L | GO:0002082,GO:0004129,GO:0005730,GO:0005739,GO:0005743,GO:0005746,GO:0005751,GO:0006123,GO:0097250,GO:1902600 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| COX7A2L | hsa:9167 | path:hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa05016 | Huntington disease - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| COX7A2L | hsa:9167 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | COX7A2L | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | COX7A2L | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | COX7A2L | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| MYC | COX7A2L | 12747840 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | COX7A2L | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP53 | COX7A2L | 16980608 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | COX7A2L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | COX7A2L | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000005481D | COX7A2L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000045147B | COX7A2L | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041E949 | COX7A2L | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000346991 | COX7A2L | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDAA | COX7A2L | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007A060 | COX7A2L | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A3D | COX7A2L | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076995 | COX7A2L | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| COX5A | COX7A2L | 25348397 | N/A | physical interaction | ComPPI |
| UQCRH | COX7A2L | 25348397 | N/A | physical interaction | ComPPI |
| U2AF2 | COX7A2L | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | COX7A2L | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | COX7A2L | 25348397 | N/A | physical interaction | ComPPI |
| MAGEA11 | COX7A2L | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| UQCRB | COX7A2L | 25348397 | N/A | physical interaction | ComPPI |
| COX7A2L | NDUFS4 | 24234451 24344204 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| COX7A2L | NDUFS5 | 24234451 24344204 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| COX7A2L | NDUFA4 | 25348397 | N/A | physical interaction | ComPPI |
| COX7A2L | COX6B1 | 25348397 | N/A | physical interaction | ComPPI |
| COX7A2L | UQCRQ | 25348397 | N/A | physical interaction | ComPPI |