GENE：MYO5A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MYO5A |
| FullNmae | myosin VA |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7602 |
| EnsembleID | ENSG00000197535 |
| Uniprot | Q9Y4I1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MYO5A | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MYO5A | GO:0000146,GO:0000146,GO:0001726,GO:0003723,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005737,GO:0005764,GO:0005769,GO:0005770,GO:0005777,GO:0005783,GO:0005829,GO:0005884,GO:0006892,GO:0007015,GO:0015031,GO:0015629,GO:0016020,GO:0016020,GO:0016192,GO:0016459,GO:0030048,GO:0030050,GO:0030050,GO:0030426,GO:0031267,GO:0031982,GO:0032402,GO:0032433,GO:0032593,GO:0032869,GO:0042470,GO:0043005,GO:0051015,GO:0055037,GO:0070062,GO:0072659 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MYO5A | hsa:4644 | path:hsa04814 | Motor proteins - Homo sapiens (human) |
| MYO5A | hsa:4644 | path:hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MYO5A | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MYO5A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | MYO5A | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | MYO5A | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | MYO5A | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | MYO5A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00004F4657 | MYO5A | 22895360 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS00002FC5B0 | MYO5A | 20371350 22473208 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS00004F4657 | MYO5A | 22895360 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00000AA464 | MYO5A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005651EE | MYO5A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000475586 | MYO5A | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003ACE11 | MYO5A | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000010BD8D | MYO5A | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E92A8 | MYO5A | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | MYO5A | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F6E49 | MYO5A | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | MYO5A | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | MYO5A | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | MYO5A | 20371350 21572407 22473208 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | MYO5A | 20371350 21572407 22473208 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | MYO5A | 20371350 21572407 22473208 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001496AE | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018CD09 | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075E2C3 | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F0130 | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032FC1A | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000E7139 | MYO5A | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CE046 | MYO5A | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003E1A9 | MYO5A | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058BB84 | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D1FC | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D2F5 | MYO5A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A052 | MYO5A | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | MYO5A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | MYO5A | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000028DE3F | MYO5A | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | MYO5A | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DYNLL1 | MYO5A | 10844022 14525934 25348397 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| DYNLL2 | MYO5A | 10844022 11546872 14525934 17029413 20889982 25348397 27898060 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD,OmniPath |
| PPP1CB | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| FBXW7 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| SMAD2 | MYO5A | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| FLNA | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| FEZ1 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| PEX19 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| HGS | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| CDH5 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| DLGAP1 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| MYC | MYO5A | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| HNRNPL | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| IQGAP1 | MYO5A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PDLIM7 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| GRIA2 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| MYO18A | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| EXOC3 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| EXOC4 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| EID1 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| CDK2 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| SCP2 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| RAB27A | MYO5A | 12006666 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CREB3 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| OS9 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| DTNBP1 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| SSH1 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| BMF | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| SYNPO | MYO5A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TRIM3 | MYO5A | 10391919 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD,OmniPath |
| ANLN | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| MLPH | MYO5A | 11856727 11980908 12006666 12062444 14525934 14730011 15059972 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| IL20RA | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| UBE2O | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| PAN2 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| MYH9 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| MYL2 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| MYO1C | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| PPP6R2 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| LIMA1 | MYO5A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PLS3 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| DBN1 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| SIRT7 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| FBXO25 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| MYO1E | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| DKK3 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| MYH11 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| AVIL | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| SHANK2 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| GRIA1 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| CAPZA2 | MYO5A | 25348397 | N/A | physical interaction | ComPPI |
| MYO5A | EXOC6 | 25348397 | N/A | physical interaction | ComPPI |
| MYO5A | CCDC8 | 25348397 | N/A | physical interaction | ComPPI |
| MYO5A | MYO5C | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MYO5A | MYO19 | 25348397 | N/A | physical interaction | ComPPI |
| MYO5A | TMOD4 | 25348397 | N/A | physical interaction | ComPPI |
| MYO5A | TMOD3 | 25348397 | N/A | physical interaction | ComPPI |
| MYO5A | LRRIQ1 | 25348397 | N/A | physical interaction | ComPPI |
| MYO5A | FHIP2B | 25348397 | N/A | physical interaction | ComPPI |
| RAB11A | MYO5A | 14525934 19009530 27898060 | N/A | two hybrid | HPRD,OmniPath |
| NEFL | MYO5A | 12403814 14525934 | N/A | experimental interaction detection | HPRD |
| PRPH | MYO5A | 12403814 14525934 | N/A | experimental interaction detection | HPRD |
| TRIM2 | MYO5A | 11432975 14525934 27898060 | N/A | experimental interaction detection | HPRD,OmniPath |
| AKT2 | MYO5A | 17515613 27898060 | N/A | N/A | OmniPath |