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GENE：EPS8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EPS8
FullNmae EGFR pathway substrate 8, signaling adaptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3420
EnsembleID ENSG00000151491
Uniprot Q12929

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EPS8 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EPS8 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EPS8 GO:0003779,GO:0003779,GO:0005515,GO:0005886,GO:0005903,GO:0005938,GO:0007266,GO:0008344,GO:0008360,GO:0010458,GO:0014069,GO:0016601,GO:0017146,GO:0030426,GO:0030832,GO:0031267,GO:0031982,GO:0032420,GO:0032426,GO:0032587,GO:0032587,GO:0035023,GO:0036336,GO:0048149,GO:0051016,GO:0051017,GO:0051764,GO:0070062,GO:0070358,GO:0098978,GO:0099072,GO:1900029,GO:1990830

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BYSL EPS8 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
EPS8 ITGB3 20005715 interaction type N/A PSP
EPS8 ITGB2 20005715 interaction type N/A PSP
EPS8 ITGB1 20005715 interaction type N/A PSP
EPS8 CD3E 20005715 interaction type N/A PSP
EPS8 SRC 20005715 interaction type N/A PSP
EPS8 ITGB5 20005715 interaction type N/A PSP
EPS8 ITGB7 20005715 interaction type N/A PSP
EPS8 SRC 10395945 18988627 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR EPS8 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 EPS8 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 EPS8 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 EPS8 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C EPS8 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EPS8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EPS8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EPS8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EPS8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 EPS8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 EPS8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 EPS8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EPS8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 EPS8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 EPS8 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 EPS8 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00004214BB EPS8 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 EPS8 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 EPS8 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000019F055 EPS8 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 EPS8 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001EE123 EPS8 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000037E170 EPS8 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EPS8 BAIAP2 25361965 interaction type N/A PTMCode2
BAIAP2 EPS8 25361965 interaction type N/A PTMCode2
EPS8 SRC 25361965 interaction type N/A PTMCode2
SRC EPS8 25361965 interaction type N/A PTMCode2
EPS8 ABI1 25361965 interaction type N/A PTMCode2
ABI1 EPS8 25361965 interaction type N/A PTMCode2
EPS8 SHB 25361965 interaction type N/A PTMCode2
SHB EPS8 25361965 interaction type N/A PTMCode2
EPS8 CASK 25361965 interaction type N/A PTMCode2
CASK EPS8 25361965 interaction type N/A PTMCode2
EPS8 DVL1 25361965 interaction type N/A PTMCode2
DVL1 EPS8 25361965 interaction type N/A PTMCode2
EPS8 SOS1 25361965 interaction type N/A PTMCode2
SOS1 EPS8 25361965 interaction type N/A PTMCode2
EPS8 SHC1 25361965 interaction type N/A PTMCode2
SHC1 EPS8 25361965 interaction type N/A PTMCode2
EGFR EPS8 25361965 interaction type N/A PTMCode2
EPS8 EGFR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BYSL EPS8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SMARCE1 EPS8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RSPH14 EPS8 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HNRNPC EPS8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AIMP2 EPS8 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ITGB5 EPS8 12606711 14525934 24234451 25348397 N/A experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
MAP1LC3B EPS8 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCDC85B EPS8 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
BORCS6 EPS8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
XAGE2 EPS8 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
CBL EPS8 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
SHB EPS8 14525934 25348397 7537362 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SRC EPS8 10395945 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SHC1 EPS8 14525934 25348397 7791787 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SOS1 EPS8 10499589 14525934 16520382 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
GRB2 EPS8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ITGB1 EPS8 25348397 N/A pull down,in vitro ComPPI
CD3E EPS8 17617578 24234451 25348397 physical association filamentous phage display ComPPI,IntAct
SERPINA5 EPS8 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ITGB3 EPS8 12606711 14525934 24234451 25348397 N/A experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
EPS8 DVL1 10581192 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
EPS8 ABI1 1049958 10499589 11099046 12127568 14525934 15289329 25348397 9010225 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EPS8 BAIAP2 14525934 15289329 16189514 19564905 24234451 24584464 25348397 25416956 25814554 26186194 27898060 physical association anti bait coimmunoprecipitation,cosedimentation in solution,experimental interaction detection,fluorescent resonance energy transfer,molecular sieving,pull down,physical interaction,two hybrid array,two hybrid pooling approach,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct,OmniPath
EPS8 USP6NL 11099046 14525934 24234451 25348397 8700527 association experimental interaction detection,in vivo ComPPI,HPRD,IntAct
EPS8 TEX28 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EPS8 HOOK2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EPS8 ACTA1 11524436 12127568 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
EPS8 MYO15A 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EPS8 MRPL20 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EPS8 CASK 14525934 16688213 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
EPS8 EGFR 12127568 14525934 24234451 24658140 25348397 7532293 physical association anti tag coimmunoprecipitation,experimental interaction detection,ubiquitin reconstruction,physical interaction,in vivo ComPPI,HPRD,IntAct
EPS8 DVL1P1 25348397 N/A physical interaction ComPPI
EPS8 BLOC1S6 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EPS8 PCM1 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
EPS8 C8ORF33 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 MDC1 25348397 N/A physical interaction ComPPI
EPS8 CFTR 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EPS8 ALDH7A1 21988832 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
EPS8 CTNNA3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 CSNK2B 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 SLC27A4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 TDP2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPS8 XRCC6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 CXCL2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 MAP3K11 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 NFKB2 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
EPS8 RFXAP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 BCKDK 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
EPS8 SF3B3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 ZZZ3 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
EPS8 GULP1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 ADAM22 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 ARMC1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 SCRN3 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
EPS8 NACC2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 PROSER2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 TPRN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPS8 ANKRD28 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
EPS8 BAIAP2L1 21098279 22921828 24234451 25348397 27898060 physical association isothermal titration calorimetry,nuclear magnetic resonance,peptide array,pull down,physical interaction ComPPI,IntAct,OmniPath
EPS8 RUNX1T1 25348397 N/A physical interaction ComPPI
EPS8 INPP5J 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EPS8 C19ORF25 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EPS8 C6ORF141 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPS8 RCAN3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPS8 AMPD2 25348397 N/A physical interaction ComPPI
EPS8 FGL1 25348397 N/A physical interaction ComPPI
EPS8 FBXW5 23314863 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPS8 GOLGA8DP 24234451 25348397 25416956 physical association two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SOX2 EPS8 25348397 N/A physical interaction ComPPI
DNALI1 EPS8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EPS8 EPS8 10499589 14525934 16189514 24234451 8700515 9010225 9303002 physical association experimental interaction detection,two hybrid pooling approach,two hybrid HPRD,IntAct
TANK EPS8 24234451 30561431 association virotrap IntAct

Source Target Pmid Interactiontype Methods Database
URS00009BDE68 EPS8 27087310 direct interaction,inhibition N/A NPInter

Visualization










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