Gene Information gene info

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GENE：GSTA4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GSTA4
FullNmae glutathione S-transferase alpha 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4629
EnsembleID ENSG00000170899
Uniprot O15217

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GSTA4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GSTA4 GO:0004364,GO:0004364,GO:0005515,GO:0005829,GO:0006749,GO:0006749,GO:0006805,GO:0006805,GO:0042802,GO:0042803

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GSTA4 hsa:2941 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa00983 Drug metabolism - other enzymes - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa05200 Pathways in cancer - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa05204 Chemical carcinogenesis - DNA adducts - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
GSTA4 hsa:2941 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR GSTA4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GSTA4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 GSTA4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 GSTA4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 GSTA4 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 GSTA4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GSTA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GSTA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GSTA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GSTA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GSTA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 GSTA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GSTA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 GSTA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002367FA GSTA4 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA GSTA4 22135298 phosphorylation N/A PhosphoSite
PRKCA GSTA4 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
BAG3 GSTA4 25348397 N/A physical interaction ComPPI
LSM1 GSTA4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GSTA2 GSTA4 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
GSTA1 GSTA4 25348397 N/A physical interaction ComPPI
GSTA4 GSTO1 25348397 N/A physical interaction ComPPI
GSTA4 TRIB2 25348397 N/A physical interaction ComPPI
GSTA4 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GSTA4 GAS8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
C2ORF50 GSTA4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GSTA4 GSTA4 10329152 14525934 16189514 24234451 25416956 9461507 physical association experimental interaction detection,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,two hybrid HPRD,IntAct
PRKCA GSTA4 12646569 27898060 N/A N/A OmniPath

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