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GENE：MCPH1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MCPH1
FullNmae microcephalin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6954
EnsembleID ENSG00000147316
Uniprot Q8NEM0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MCPH1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MCPH1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MCPH1 GO:0000122,GO:0000132,GO:0000278,GO:0005515,GO:0005654,GO:0005737,GO:0005815,GO:0021987,GO:0042802,GO:0046605,GO:0050727,GO:0060348,GO:0060623,GO:0071539,GO:0097150

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PHF11 MCPH1 21988832 23180781 physical association two hybrid array InnateDB

Source Target Pmid Interactiontype Methods Database
AR MCPH1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MCPH1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MCPH1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 MCPH1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MCPH1 18971253 22136275 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MCPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 MCPH1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000041CB9C MCPH1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 MCPH1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
RPA1 MCPH1 25361965 interaction type N/A PTMCode2
MCPH1 RPA1 25361965 interaction type N/A PTMCode2
MCPH1 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 MCPH1 25361965 interaction type N/A PTMCode2
MCPH1 TP53BP1 25361965 interaction type N/A PTMCode2
TP53BP1 MCPH1 25361965 interaction type N/A PTMCode2
MCPH1 MDC1 25361965 interaction type N/A PTMCode2
MDC1 MCPH1 25361965 interaction type N/A PTMCode2
SMARCC2 MCPH1 25361965 interaction type N/A PTMCode2
MCPH1 SMARCC2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NMI MCPH1 25348397 N/A physical interaction ComPPI
LGALS3 MCPH1 25348397 N/A physical interaction ComPPI
MITD1 MCPH1 25348397 N/A physical interaction ComPPI
CTSL MCPH1 25348397 N/A physical interaction ComPPI
VIM MCPH1 25348397 N/A physical interaction ComPPI
ACTG1 MCPH1 25348397 N/A physical interaction ComPPI
SMARCC1 MCPH1 25348397 N/A physical interaction ComPPI
TP53BP1 MCPH1 25348397 N/A physical interaction ComPPI
MCM5 MCPH1 25348397 N/A physical interaction ComPPI
GABARAPL2 MCPH1 25348397 N/A physical interaction ComPPI
UXT MCPH1 25348397 N/A physical interaction ComPPI
MCM2 MCPH1 25348397 N/A physical interaction ComPPI
RACK1 MCPH1 25348397 N/A physical interaction ComPPI
S100A16 MCPH1 25348397 N/A physical interaction ComPPI
ATR MCPH1 25348397 N/A physical interaction ComPPI
RBM39 MCPH1 25348397 N/A physical interaction ComPPI
FZR1 MCPH1 25348397 N/A physical interaction ComPPI
FLNA MCPH1 25348397 N/A physical interaction ComPPI
ENO1 MCPH1 25348397 N/A physical interaction ComPPI
E2F1 MCPH1 18660752 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
SMARCA4 MCPH1 25348397 N/A physical interaction ComPPI
RPA1 MCPH1 25348397 N/A physical interaction ComPPI
DNAJA3 MCPH1 25348397 N/A physical interaction ComPPI
AKR7A2 MCPH1 25348397 N/A physical interaction ComPPI
HNRNPL MCPH1 25348397 N/A physical interaction ComPPI
COPB2 MCPH1 25348397 N/A physical interaction ComPPI
ABCC2 MCPH1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF3F MCPH1 25348397 N/A physical interaction ComPPI
RAD51 MCPH1 25348397 N/A physical interaction ComPPI
BRCA2 MCPH1 25348397 N/A physical interaction ComPPI
ATM MCPH1 25348397 N/A physical interaction ComPPI
E2F2 MCPH1 18660752 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SMARCB1 MCPH1 25348397 N/A physical interaction ComPPI
CRACR2A MCPH1 25348397 N/A physical interaction ComPPI
TRAP1 MCPH1 25348397 N/A physical interaction ComPPI
RNF8 MCPH1 18001825 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
HNRNPA2B1 MCPH1 25348397 N/A physical interaction ComPPI
TPT1 MCPH1 25348397 N/A physical interaction ComPPI
PPA1 MCPH1 25348397 N/A physical interaction ComPPI
CHEK1 MCPH1 25348397 N/A physical interaction ComPPI
CCT5 MCPH1 25348397 N/A physical interaction ComPPI
POLD1 MCPH1 25348397 N/A physical interaction ComPPI
USP8 MCPH1 25348397 N/A physical interaction ComPPI
COPS3 MCPH1 25348397 N/A physical interaction ComPPI
MDC1 MCPH1 25348397 N/A physical interaction ComPPI
FBLN1 MCPH1 25348397 N/A physical interaction ComPPI
H2AX MCPH1 25348397 N/A physical interaction ComPPI
NBN MCPH1 25348397 N/A physical interaction ComPPI
PPRC1 MCPH1 25348397 N/A physical interaction ComPPI
COL1A1 MCPH1 25348397 N/A physical interaction ComPPI
EIF4A2 MCPH1 25348397 N/A physical interaction ComPPI
KDM1A MCPH1 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BRCA1 MCPH1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
AKIP1 MCPH1 25348397 N/A physical interaction ComPPI
SMARCC2 MCPH1 25348397 N/A physical interaction ComPPI
TERF2 MCPH1 19287395 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
TERF2IP MCPH1 19287395 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC6 MCPH1 25348397 N/A physical interaction ComPPI
TADA2A MCPH1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FBXW11 MCPH1 25348397 N/A physical interaction ComPPI
POLR2G MCPH1 25348397 N/A physical interaction ComPPI
MT2A MCPH1 25348397 N/A physical interaction ComPPI
RSL24D1 MCPH1 25348397 N/A physical interaction ComPPI
RUVBL2 MCPH1 25348397 N/A physical interaction ComPPI
HSPD1 MCPH1 25348397 N/A physical interaction ComPPI
CDC27 MCPH1 22139841 25348397 27898060 N/A physical interaction ComPPI,OmniPath
WDR61 MCPH1 25348397 N/A physical interaction ComPPI
NR2F1 MCPH1 25348397 N/A physical interaction ComPPI
KAT5 MCPH1 25348397 N/A physical interaction ComPPI
LAMTOR5 MCPH1 25348397 N/A physical interaction ComPPI
ZMIZ2 MCPH1 25348397 N/A physical interaction ComPPI
EMG1 MCPH1 25348397 N/A physical interaction ComPPI
TAF1D MCPH1 25348397 N/A physical interaction ComPPI
THAP11 MCPH1 25348397 N/A physical interaction ComPPI
CHD4 MCPH1 25348397 N/A physical interaction ComPPI
PMVK MCPH1 25348397 N/A physical interaction ComPPI
SMARCA2 MCPH1 25348397 N/A physical interaction ComPPI
TSEN54 MCPH1 25348397 N/A physical interaction ComPPI
DNAJC19 MCPH1 25348397 N/A physical interaction ComPPI
SUPT6H MCPH1 25348397 N/A physical interaction ComPPI
WDR75 MCPH1 25348397 N/A physical interaction ComPPI
MCPH1 PHF11 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MCPH1 OBSL1 25348397 N/A physical interaction ComPPI
MCPH1 B3GALT6 25348397 N/A physical interaction ComPPI
MCPH1 CCDC77 25348397 N/A physical interaction ComPPI
MCPH1 COL27A1 25348397 N/A physical interaction ComPPI
MCPH1 MRPL46 25348397 N/A physical interaction ComPPI
MCPH1 NCCRP1 25348397 N/A physical interaction ComPPI
MCPH1 SMOX 25348397 N/A physical interaction ComPPI
MCPH1 WDR53 25348397 N/A physical interaction ComPPI
MCPH1 WDR73 25348397 N/A physical interaction ComPPI
MCPH1 WNT10B 25348397 N/A physical interaction ComPPI
MCPH1 ZNF827 25348397 N/A physical interaction ComPPI
MCPH1 MCPH1 18660752 24234451 physical association anti tag coimmunoprecipitation,bimolecular fluorescence complementation IntAct
NCBP3 MCPH1 24234451 26382858 association pull down IntAct
MCPH1 E2F1 18660752 23001041 27898060 stimulant N/A OmniPath
MCPH1 SMARCC2 19525936 27898060 stimulant N/A OmniPath
H2AX MCPH1 17599047 22154951 25733871 27898060 stimulant N/A OmniPath
MCPH1 BRCA2 19549900 20107607 27898060 stimulant N/A OmniPath

Visualization










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