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GENE：PAK6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PAK6
FullNmae p21 (RAC1) activated kinase 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16061
EnsembleID ENSG00000137843
Uniprot Q9NQU5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PAK6 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PAK6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PAK6 GO:0001650,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006468,GO:0006915,GO:0007010,GO:0007612,GO:0007613,GO:0007626,GO:0014069,GO:0016310,GO:0030054,GO:0035556,GO:0043408,GO:0045296,GO:0106310,GO:0140058,GO:1990138

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PAK6 hsa:56924 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PAK6 hsa:56924 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PAK6 hsa:56924 path:hsa04360 Axon guidance - Homo sapiens (human)
PAK6 hsa:56924 path:hsa04510 Focal adhesion - Homo sapiens (human)
PAK6 hsa:56924 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PAK6 hsa:56924 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PAK6 hsa:56924 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PAK6 hsa:56924 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PAK6 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP PAK6 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 PAK6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PAK6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PAK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 PAK6 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 PAK6 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 PAK6 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000076B539 PAK6 19536157 22927820 23313552 23824327 24906430 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000204177 PAK6 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000025EABA PAK6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PAK6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PAK6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PAK6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PAK6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA PAK6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PAK6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PAK6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B PAK6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 PAK6 23313552 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002F5FEE PAK6 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK14 PAK6 22135298 phosphorylation N/A PhosphoSite
MAP2K6 PAK6 22135298 phosphorylation N/A PhosphoSite
PAK6 MDM2 22135298 phosphorylation N/A PhosphoSite
PAK6 PACSIN1 22135298 phosphorylation N/A PhosphoSite
PAK6 AR 22135298 phosphorylation N/A PhosphoSite
PAK6 LIMK1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDC42 PAK6 11773441 14525934 20936779 24234451 25348397 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro ComPPI,HPRD,IntAct
YWHAG PAK6 25348397 N/A physical interaction ComPPI
RAC1 PAK6 25348397 N/A physical interaction ComPPI
HSP90AB1 PAK6 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
AR PAK6 11278661 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAPK14 PAK6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
YWHAZ PAK6 25348397 N/A physical interaction ComPPI
HSP90AA1 PAK6 25348397 N/A physical interaction ComPPI
CDH1 PAK6 25348397 N/A physical interaction ComPPI
SNX2 PAK6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PKM PAK6 25348397 N/A protein kinase assay ComPPI
YWHAQ PAK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MDM2 PAK6 25348397 N/A physical interaction ComPPI
YWHAE PAK6 25348397 N/A physical interaction ComPPI
TPD52L1 PAK6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PAK4 PAK6 25348397 N/A physical interaction ComPPI
RHOJ PAK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PAK6 ESR1 11773441 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PAK6 LNX1 25348397 N/A physical interaction ComPPI
PAK6 APP 25348397 N/A physical interaction ComPPI
PAK6 HSP90AA2P 25348397 N/A physical interaction ComPPI
PAK6 NEK6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PAK6 CDK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PAK6 SEMA3B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PAK6 LRRK2 24234451 24510904 24947832 25348397 N/A protein array ComPPI,IntAct
PAK6 LRRK1 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
PAK6 RHOV 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK6 HSF2BP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK6 PTPRD 22305495 24234451 25348397 N/A protein array ComPPI,IntAct
PAK6 DAPK1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
AURKB PAK6 14573606 15550393 27898060 N/A N/A OmniPath
MAPK14 PAK6 15550393 21900206 27898060 stimulant N/A OmniPath
PAK6 AR 11278661 11773441 14573606 23132866 27898060 stimulant N/A OmniPath
MAP2K6 PAK6 15550393 27898060 stimulant N/A OmniPath
PAK6 PACSIN1 24204982 27898060 N/A N/A OmniPath

Visualization










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