Gene Information gene info

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GENE：PDE3A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDE3A
FullNmae phosphodiesterase 3A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8778
EnsembleID ENSG00000172572
Uniprot Q14432

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDE3A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDE3A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PDE3A GO:0001556,GO:0004114,GO:0004115,GO:0004115,GO:0004115,GO:0004119,GO:0005515,GO:0005829,GO:0005829,GO:0005829,GO:0006629,GO:0007186,GO:0009410,GO:0016020,GO:0019933,GO:0019933,GO:0019934,GO:0019934,GO:0030284,GO:0040020,GO:0043066,GO:0043116,GO:0043117,GO:0043401,GO:0043951,GO:0043951,GO:0046872,GO:0047555,GO:0060282,GO:0060700,GO:0060700,GO:0071321,GO:0071560,GO:0097190,GO:0097190,GO:0099130

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDE3A hsa:5139 path:hsa00230 Purine metabolism - Homo sapiens (human)
PDE3A hsa:5139 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PDE3A hsa:5139 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
PDE3A hsa:5139 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PDE3A hsa:5139 path:hsa04924 Renin secretion - Homo sapiens (human)
PDE3A hsa:5139 path:hsa05032 Morphine addiction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA3 PDE3A 19559773 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 PDE3A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IGF1R PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PDE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 PDE3A N/A rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 PDE3A 18668040 23313552 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS0000044FD7 PDE3A 24039954 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000011A030 PDE3A 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000458AD2 PDE3A 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 PDE3A 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000057FDB8 PDE3A 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD PDE3A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000032BDF4 PDE3A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000B59A2 PDE3A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 PDE3A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000096022 PDE3A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD PDE3A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 PDE3A 19536157 23313552 23824327 24906430 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000076B539 PDE3A 19536157 23824327 24906430 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00003E6EFA PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000116F83 PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EBD4B PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002AA55A PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000A939F PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 PDE3A 23313552 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00002C0FCB PDE3A 23313552 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00002FAA8C PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 PDE3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 PDE3A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000031F6C2 PDE3A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PDE3A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000302909 PDE3A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005BB0FD PDE3A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000035AC91 PDE3A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00003E5ECC PDE3A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000047A8F PDE3A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000214763 PDE3A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA PDE3A 22135298 phosphorylation N/A PhosphoSite
PRKCA PDE3A 22135298 phosphorylation N/A PhosphoSite
PDE3A ARFGEF2 25361965 interaction type N/A PTMCode2
ARFGEF2 PDE3A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PRKACA PDE3A 25348397 N/A physical interaction ComPPI
JUP PDE3A 25348397 N/A physical interaction ComPPI
YWHAZ PDE3A 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
PRKAR1A PDE3A 19332778 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA5 PDE3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAQ PDE3A 25348397 N/A physical interaction ComPPI
ARFGEF1 PDE3A 19332778 24234451 25348397 association,physical association anti bait coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
MMS19 PDE3A 25348397 N/A physical interaction ComPPI
TRIM25 PDE3A 25348397 N/A physical interaction ComPPI
UBE4B PDE3A 25348397 N/A physical interaction ComPPI
AKT1 PDE3A 25348397 N/A physical interaction ComPPI
FBXO7 PDE3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DPYSL2 PDE3A 25348397 N/A physical interaction ComPPI
GANAB PDE3A 25348397 N/A physical interaction ComPPI
CSDE1 PDE3A 25348397 N/A physical interaction ComPPI
GMPPB PDE3A 25348397 N/A physical interaction ComPPI
KIF11 PDE3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CCDC88A PDE3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WDR62 PDE3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MSH2 PDE3A 25348397 N/A physical interaction ComPPI
TUBA1C PDE3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRMT1 PDE3A 25348397 N/A physical interaction ComPPI
ARFGEF2 PDE3A 19332778 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP6V1B2 PDE3A 25348397 N/A physical interaction ComPPI
PDE3A RANBP6 25348397 N/A physical interaction ComPPI
PDE3A TRPC6 21799177 27898060 N/A N/A OmniPath
PRKACA PDE3A 16153182 27898060 2839485 stimulant N/A OmniPath
PRKCA PDE3A 16153182 19261611 24248367 25593322 27898060 stimulant N/A OmniPath

Visualization










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