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GENE：PKP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PKP2
FullNmae plakophilin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9024
EnsembleID ENSG00000057294
Uniprot Q99959

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PKP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PKP2 GO:0001533,GO:0002159,GO:0002934,GO:0005080,GO:0005080,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005882,GO:0005882,GO:0005886,GO:0005886,GO:0005886,GO:0005911,GO:0005911,GO:0005912,GO:0007043,GO:0007507,GO:0007507,GO:0010765,GO:0010810,GO:0014704,GO:0014704,GO:0014704,GO:0016020,GO:0017080,GO:0019215,GO:0019215,GO:0030054,GO:0030057,GO:0030057,GO:0030057,GO:0044325,GO:0045110,GO:0045110,GO:0045294,GO:0045294,GO:0045296,GO:0045296,GO:0048496,GO:0055010,GO:0060090,GO:0060090,GO:0072659,GO:0072659,GO:0086002,GO:0086005,GO:0086019,GO:0086019,GO:0086064,GO:0086073,GO:0086083,GO:0086091,GO:0098609,GO:0098609,GO:0098609,GO:0098911,GO:1900024

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PKP2 hsa:5318 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TFAP2C PKP2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA PKP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PKP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PKP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PKP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PKP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PKP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 PKP2 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000EC1BE PKP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 PKP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 PKP2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PKP2 DSG2 25361965 interaction type N/A PTMCode2
DSG2 PKP2 25361965 interaction type N/A PTMCode2
PKP2 JUP 25361965 interaction type N/A PTMCode2
JUP PKP2 25361965 interaction type N/A PTMCode2
PKP2 POLR3A 25361965 interaction type N/A PTMCode2
POLR3A PKP2 25361965 interaction type N/A PTMCode2
PKP2 DSP 25361965 interaction type N/A PTMCode2
DSP PKP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRT18 PKP2 10852826 14525934 24234451 25348397 physical association experimental interaction detection,far western blotting,physical interaction,in vitro ComPPI,HPRD,IntAct
KRT5 PKP2 10852826 14525934 24234451 25348397 physical association experimental interaction detection,far western blotting,physical interaction,in vitro ComPPI,HPRD,IntAct
VIM PKP2 10852826 24234451 25348397 physical association far western blotting ComPPI,IntAct
YWHAG PKP2 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMI1 PKP2 25348397 N/A physical interaction ComPPI
GTF2B PKP2 25348397 N/A physical interaction ComPPI
ERBB2 PKP2 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
GRN PKP2 25348397 N/A physical interaction ComPPI
CUL3 PKP2 25348397 N/A physical interaction ComPPI
JUP PKP2 11790773 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YWHAB PKP2 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ PKP2 12941695 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
APC PKP2 25348397 N/A physical interaction ComPPI
CDH1 PKP2 25348397 N/A physical interaction ComPPI
PKP2 SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKP2 MARK3 12941695 24234451 25348397 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,IntAct
PKP2 POLR3A 11416169 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PKP2 CTNNB1 11790773 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
PKP2 DSC1 11790773 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PKP2 DSC2 11790773 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PKP2 DSP 11790773 14525934 24234451 25225338 25348397 physical association two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
PKP2 DSG1 11790773 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PKP2 DSG2 11790773 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PKP2 SFN 15778465 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
PKP2 YWHAE 25348397 N/A physical interaction ComPPI
PKP2 CLK2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PKP2 DROSHA 25348397 N/A physical interaction ComPPI
PKP2 CEP250 25348397 N/A physical interaction ComPPI
PKP2 MTUS2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKP2 NDEL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKP2 EED 25348397 N/A physical interaction ComPPI
PKP2 RNF2 25348397 N/A physical interaction ComPPI
PKP2 ILK 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PKP2 MAST3 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PKP2 EFNB2 25348397 N/A physical interaction ComPPI
PKP2 MINDY3 25348397 N/A physical interaction ComPPI
PKP2 LPAR6 25348397 N/A physical interaction ComPPI
PKP2 PTGER3 25348397 N/A physical interaction ComPPI
PKP2 HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
PKP2 RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PKP2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PKP2 MATR3 25348397 N/A physical interaction ComPPI
PKP2 SEC16A 25348397 N/A physical interaction ComPPI
PKP2 GTSE1 25348397 N/A physical interaction ComPPI
PKP2 ESRRB 25348397 N/A physical interaction ComPPI
PKP2 EYA4 25348397 N/A physical interaction ComPPI
PKP2 TACR1 25348397 N/A physical interaction ComPPI
PKP2 HAVCR2 25348397 N/A physical interaction ComPPI
PKP2 TMEM52B 25348397 N/A physical interaction ComPPI
PKP2 NTAQ1 25348397 N/A physical interaction ComPPI
PKP2 SLC14A2 25348397 N/A physical interaction ComPPI
PKP2 PCDHGB1 25348397 N/A physical interaction ComPPI
PKP2 KLHL40 25348397 N/A physical interaction ComPPI
PKP2 LRRC4C 25348397 N/A physical interaction ComPPI
PKP2 TNFRSF19 25348397 N/A physical interaction ComPPI
PKP2 G3BP1 25348397 N/A physical interaction ComPPI
PKP2 GTF2IRD1 25348397 N/A physical interaction ComPPI
PKP2 EGFR 15657067 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PKP2 YWHAH 17979178 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PKP2 TRMT10C 18984158 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PKP2 FOS 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PKP2 MCM7 23764002 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PKP2 KRT8 10852826 24234451 25348397 physical association far western blotting ComPPI,IntAct
PKP2 KRT14 10852826 24234451 25348397 physical association far western blotting ComPPI,IntAct
PKP2 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
YWHAQ PKP2 25348397 N/A physical interaction ComPPI
PKP2 PKP2 10852826 14525934 N/A experimental interaction detection HPRD
MKI67 PKP2 24234451 26949251 association anti tag coimmunoprecipitation IntAct
L1TD1 PKP2 24234451 25702638 association anti bait coimmunoprecipitation IntAct

Visualization










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