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GENE：PSENEN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSENEN
FullNmae presenilin enhancer, gamma-secretase subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30100
EnsembleID ENSG00000205155
Uniprot Q9NZ42

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSENEN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PSENEN GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0006509,GO:0007219,GO:0007220,GO:0007220,GO:0007220,GO:0010008,GO:0010950,GO:0010950,GO:0016020,GO:0016485,GO:0016485,GO:0016485,GO:0019899,GO:0031293,GO:0031293,GO:0032580,GO:0034205,GO:0034205,GO:0042734,GO:0042982,GO:0042987,GO:0042987,GO:0042987,GO:0042987,GO:0042987,GO:0043085,GO:0061133,GO:0061133,GO:0070765,GO:0070765,GO:0070765,GO:0070765,GO:0070765

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSENEN hsa:55851 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
PSENEN hsa:55851 path:hsa05010 Alzheimer disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PSEN1 PSENEN 12198112 12522139 14572442 21071413 23331499 interaction type N/A SignaLink,SignaLink
PSENEN PSEN1 12198112 12639958 14572442 15035625 18988627 21071413 23331499 inhibition N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
APH1A PSENEN 14572442 20005715 21071413 interaction type N/A PSP,SignaLink
NCSTN PSENEN 20005715 interaction type N/A PSP
NCSTN PSENEN 12198112 14572442 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
URS0000160683 PSENEN 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000019907A PSENEN 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000137EDE PSENEN 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000017CCCB PSENEN 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AB32B PSENEN 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075BEA7 PSENEN 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075A608 PSENEN 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PSENEN 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PSENEN NCSTN 25361965 interaction type N/A PTMCode2
NCSTN PSENEN 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FTL PSENEN 23685131 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid ComPPI,IntAct,OmniPath
THBD PSENEN 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 PSENEN 12198112 12639958 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NCSTN PSENEN 12198112 14525934 16641999 18201567 24234451 25348397 physical association anti bait coimmunoprecipitation,cosedimentation,cosedimentation in solution,experimental interaction detection,physical interaction,blue native page,in vitro ComPPI,HPRD,IntAct
CREB3 PSENEN 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
APH1A PSENEN 19376115 24234451 25348397 26280335 association,physical association anti tag coimmunoprecipitation,physical interaction,electron tomography,in vivo ComPPI,IntAct
APH1B PSENEN 25348397 N/A physical interaction ComPPI
PSENEN TMED10 14525934 16641999 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PSENEN PSEN1 12198112 12639958 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PSENEN ERLIN2 25348397 N/A physical interaction ComPPI
PSENEN GSAP 25348397 N/A physical interaction ComPPI
PSENEN SLC10A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSENEN SLC10A6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSENEN APP 12011466 27898060 N/A N/A OmniPath
PSENEN JAG2 12551931 27898060 N/A N/A OmniPath
PSEN1 PSENEN 12198112 12522139 12639958 14572442 15035625 15474363 22074918 27898060 N/A N/A OmniPath
PSENEN PSEN1 12198112 12522139 12639958 14572442 15035625 15474363 22074918 27898060 inhibition,stimulant N/A OmniPath
PSENEN RYK 19000841 27898060 stimulant N/A OmniPath
APH1A PSENEN 12522139 12740439 14572442 15322109 15474363 17911105 19376115 22074918 27898060 stimulant N/A OmniPath
APH1B PSENEN 12522139 27898060 stimulant N/A OmniPath

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