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GENE：SMAD6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMAD6
FullNmae SMAD family member 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6772
EnsembleID ENSG00000137834
Uniprot O43541

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMAD6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SMAD6 GO:0000785,GO:0000976,GO:0001657,GO:0003148,GO:0003180,GO:0003183,GO:0003184,GO:0003281,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005794,GO:0005829,GO:0005829,GO:0006357,GO:0006955,GO:0007179,GO:0007352,GO:0008285,GO:0009653,GO:0016604,GO:0030154,GO:0030279,GO:0030509,GO:0030509,GO:0030512,GO:0030512,GO:0030514,GO:0030514,GO:0031589,GO:0031625,GO:0032496,GO:0032926,GO:0032991,GO:0034616,GO:0034713,GO:0035904,GO:0042802,GO:0043066,GO:0043627,GO:0045444,GO:0045668,GO:0046872,GO:0060392,GO:0060395,GO:0060976,GO:0070410,GO:0070411,GO:0070411,GO:0070412,GO:0070698,GO:0071144,GO:0140311,GO:0140416,GO:0140416,GO:0140416,GO:1902895

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SMAD6 hsa:4091 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD6 MAP3K7 10748100 11737269 23180781 physical association anti tag coimmunoprecipitation InnateDB
TAB1 SMAD6 11737269 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD6 ITCH 15946939 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD6 PELI1 16951688 19352540 23180781 23331499 stimulation,physical association anti tag coimmunoprecipitation,two hybrid InnateDB,SignaLink
SMAD6 SMAD6 10722652 12857866 20663871 22298955 26467481 9892110 bind,up-regulates activity,down-regulates,down-regulates activity N/A Signor
SMAD6 SMAD1 11483516 12857866 18988627 21071413 23331499 9256479 9335505 stimulation N/A SignaLink,SignaLink
SMAD6 TGFBR1 23331499 9892110 stimulation N/A SignaLink,SignaLink
SMAD6 SMAD3 23331499 9892110 stimulation N/A SignaLink,SignaLink
SMAD6 SMAD2 21071413 23331499 9256479 9892110 stimulation N/A SignaLink,SignaLink
SMAD6 BMPR1A 10564272 23331499 stimulation N/A SignaLink,SignaLink
SMAD6 ACVR1 10564272 23331499 stimulation N/A SignaLink,SignaLink
SMURF1 SMAD6 11278251 15123739 15221015 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
PRMT1 SMAD6 23747011 methylation reaction,inhibition N/A SignaLink
UBE2O SMAD6 23455153 ubiquitination reaction,inhibition N/A SignaLink
SMAD6 BMPR1B 10564272 23331499 stimulation N/A SignaLink
SMAD6 TAB1 11737269 23331499 stimulation N/A SignaLink
SMAD6 HOXC8 10722652 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR SMAD6 18971253 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 SMAD6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SMAD6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SMAD6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C SMAD6 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SMAD6 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SMAD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 SMAD6 14755548 trascriptional regulation,stimulation inferred by curator TFlink
JUN SMAD6 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC SMAD6 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 SMAD6 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 SMAD6 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 SMAD6 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 SMAD6 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA SMAD6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F SMAD6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 SMAD6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 SMAD6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SMAD6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SMAD6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SMAD6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 SMAD6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 SMAD6 25074381 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000040EC3B SMAD6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 SMAD6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 SMAD6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 SMAD6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042E8CC SMAD6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 SMAD6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 SMAD6 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKX SMAD6 22135298 phosphorylation N/A PhosphoSite
BMPR1B SMAD6 25361965 interaction type N/A PTMCode2
SMAD6 BMPR1B 25361965 interaction type N/A PTMCode2
TOB1 SMAD6 25361965 interaction type N/A PTMCode2
SMAD6 TOB1 25361965 interaction type N/A PTMCode2
SMAD7 SMAD6 25361965 interaction type N/A PTMCode2
SMAD6 SMAD7 25361965 interaction type N/A PTMCode2
SMURF2 SMAD6 25361965 interaction type N/A PTMCode2
SMAD6 SMURF2 25361965 interaction type N/A PTMCode2
SMAD6 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 SMAD6 25361965 interaction type N/A PTMCode2
SMAD6 STAMBP 25361965 interaction type N/A PTMCode2
STAMBP SMAD6 25361965 interaction type N/A PTMCode2
HOXC8 SMAD6 25361965 interaction type N/A PTMCode2
SMAD6 HOXC8 25361965 interaction type N/A PTMCode2
WWP1 SMAD6 25361965 interaction type N/A PTMCode2
SMAD6 WWP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 SMAD6 25348397 N/A physical interaction ComPPI
FKBP1A SMAD6 16720724 24234451 25348397 physical association two hybrid ComPPI,IntAct
SMAD4 SMAD6 25348397 N/A physical interaction ComPPI
SMURF2 SMAD6 14525934 15231748 15761153 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
TOB1 SMAD6 12782279 14525934 25348397 27898060 N/A two hybrid,two hybrid ComPPI,HPRD,OmniPath
SMAD1 SMAD6 11483516 14525934 24234451 25348397 9436979 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RNF111 SMAD6 14525934 14657019 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD7 SMAD6 14525934 25348397 9256479 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RUNX2 SMAD6 14525934 16299379 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
SMAD2 SMAD6 25348397 N/A physical interaction ComPPI
SMAD5 SMAD6 25348397 N/A physical interaction ComPPI
CTBP1 SMAD6 14645520 24850914 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CTBP2 SMAD6 25348397 N/A physical interaction ComPPI
WWP1 SMAD6 25348397 N/A physical interaction ComPPI
UBB SMAD6 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC SMAD6 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A SMAD6 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 SMAD6 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
WWP2 SMAD6 25348397 N/A physical interaction ComPPI
PIGR SMAD6 25348397 N/A physical interaction ComPPI
PRKX SMAD6 16491121 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,protein kinase assay ComPPI,IntAct
BMPR2 SMAD6 25348397 N/A physical interaction ComPPI
MAPK6 SMAD6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEDD4L SMAD6 25348397 N/A physical interaction ComPPI
CUL2 SMAD6 25348397 N/A physical interaction ComPPI
RPS6KA5 SMAD6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ACVR1B SMAD6 25348397 N/A physical interaction ComPPI
ZEB1 SMAD6 25348397 N/A physical interaction ComPPI
YAP1 SMAD6 25348397 N/A physical interaction ComPPI
BMPR1B SMAD6 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
STRAP SMAD6 10757800 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ITCH SMAD6 25348397 N/A physical interaction ComPPI
PIAS4 SMAD6 25348397 N/A physical interaction ComPPI
USP11 SMAD6 25348397 N/A physical interaction ComPPI
MAP3K7 SMAD6 10748100 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR2B SMAD6 25348397 N/A physical interaction ComPPI
MYD88 SMAD6 25348397 N/A physical interaction ComPPI
NEDD4 SMAD6 25348397 N/A physical interaction ComPPI
SMURF1 SMAD6 11278251 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1 SMAD6 25348397 N/A physical interaction ComPPI
ELAVL1 SMAD6 25348397 N/A physical interaction ComPPI
BMPR1A SMAD6 25348397 N/A physical interaction ComPPI
STAMBP SMAD6 11483516 14525934 25348397 N/A anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
SMAD6 HOXC8 10722652 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SMAD6 TAB1 11737269 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD6 TSC22D1 25348397 N/A physical interaction ComPPI
SMAD6 TGFBR1 14525934 25348397 9335505 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD6 ACTR1B 25348397 N/A physical interaction ComPPI
SMAD6 BAMBI 25348397 N/A physical interaction ComPPI
SMAD6 UBE2O 23455153 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD6 USP15 25348397 N/A physical interaction ComPPI
SMAD6 BPIFA1 25348397 N/A physical interaction ComPPI
SMAD6 LYZ 25348397 N/A physical interaction ComPPI
SMAD6 NASP 25348397 N/A physical interaction ComPPI
SMAD6 RNF165 23610558 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PELI1 SMAD6 25348397 N/A physical interaction ComPPI
SMAD6 SMAD6 24234451 9436979 physical association anti tag coimmunoprecipitation,two hybrid IntAct
CHRM5 SMAD6 24234451 28298427 physical association ubiquitin reconstruction IntAct
MAP3K7 SMAD6 10748100 11737269 27898060 N/A N/A OmniPath
SMAD6 MAP3K7 10748100 11737269 27898060 inhibition N/A OmniPath
SMAD6 SMAD1 11483516 12857866 27898060 9256479 9335505 9436979 inhibition,stimulant N/A OmniPath
SMAD6 HOXC8 10722652 27898060 inhibition,stimulant N/A OmniPath
SMAD6 SMAD2 27898060 9256479 989211 9892110 inhibition,stimulant N/A OmniPath
SMAD6 NR2C2 11737269 27898060 inhibition N/A OmniPath
SMAD6 SMAD4 15817471 22298955 27898060 9256479 inhibition N/A OmniPath
SMAD6 TAB1 11737269 27898060 inhibition,stimulant N/A OmniPath
TAB1 SMAD6 11737269 27898060 N/A N/A OmniPath
SMAD6 TGFBR1 20663871 27898060 9335505 9436979 9892110 inhibition,stimulant N/A OmniPath
SMAD6 SMAD3 27898060 9892110 inhibition,stimulant N/A OmniPath
SMAD6 BMPR1A 10564272 27898060 inhibition,stimulant N/A OmniPath
SMAD6 BMPR1B 10564272 11483516 15761153 27898060 9436979 stimulant N/A OmniPath
UBE2O SMAD6 23455153 27898060 inhibition N/A OmniPath
SMAD6 ACVR1 10564272 20663871 23455153 27898060 stimulant N/A OmniPath
SMAD6 PELI1 16951688 19352540 27898060 stimulant N/A OmniPath
SMURF1 SMAD6 11278251 15221015 17676934 21897371 22298955 27898060 inhibition,stimulant N/A OmniPath
PRKX SMAD6 16491121 27898060 N/A N/A OmniPath

Visualization










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