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GENE：SOCS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SOCS2
FullNmae suppressor of cytokine signaling 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19382
EnsembleID ENSG00000120833
Uniprot O14508

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SOCS2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SOCS2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SOCS2 GO:0001558,GO:0005131,GO:0005159,GO:0005515,GO:0005737,GO:0005829,GO:0005942,GO:0007259,GO:0007595,GO:0008269,GO:0009966,GO:0016567,GO:0032355,GO:0032870,GO:0035556,GO:0040015,GO:0043066,GO:0045666,GO:0046426,GO:0046854,GO:0046935,GO:0060396,GO:0060749

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SOCS2 hsa:8835 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
SOCS2 hsa:8835 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
SOCS2 hsa:8835 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
SOCS2 hsa:8835 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
SOCS2 hsa:8835 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SOCS2 SOCS3 16199887 23180781 physical association his pull down InnateDB
GHR SOCS2 12135564 23180781 physical association gst pull down,competition binding InnateDB
MACROH2A1 SOCS2 23180781 24752897 physical association anti tag coimmunoprecipitation InnateDB
PELP1 SOCS2 23180781 24752897 physical association anti tag coimmunoprecipitation InnateDB
SOCS2 GH1 24243840 29145629 physical association inferred by curator Reactome
SOCS2 GHR 24243840 29145629 physical association inferred by curator Reactome
SOCS2 GH2 24243840 29145629 physical association inferred by curator Reactome
SOCS2 IGF1R 16574995 23331499 9727029 stimulation N/A SignaLink
SOCS2 LEPR 18708154 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SOCS2 INSR 20005715 interaction type N/A PSP
SOCS2 IGF1R 20005715 interaction type N/A PSP
SOCS2 PTK2 20005715 interaction type N/A PSP
SOCS2 IGF1R 20005715 N/A N/A SignaLink
SOCS2 INSR 20005715 N/A N/A SignaLink
SOCS2 PTK2 16189514 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 SOCS2 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA1 SOCS2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 SOCS2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SOCS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 SOCS2 22291912 trascriptional regulation,stimulation inferred by curator TFlink
IRF3 SOCS2 22291912 trascriptional regulation,stimulation inferred by curator TFlink
MYB SOCS2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F0F49 SOCS2 25416803 27038552 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SOCS2 PRLR 25361965 interaction type N/A PTMCode2
PRLR SOCS2 25361965 interaction type N/A PTMCode2
GHR SOCS2 25361965 interaction type N/A PTMCode2
SOCS2 GHR 25361965 interaction type N/A PTMCode2
LEPR SOCS2 25361965 interaction type N/A PTMCode2
SOCS2 LEPR 25361965 interaction type N/A PTMCode2
IGF1R SOCS2 25361965 interaction type N/A PTMCode2
SOCS2 IGF1R 25361965 interaction type N/A PTMCode2
EPOR SOCS2 25361965 interaction type N/A PTMCode2
SOCS2 EPOR 25361965 interaction type N/A PTMCode2
INSR SOCS2 25361965 interaction type N/A PTMCode2
SOCS2 INSR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CUL5 SOCS2 16684815 19385048 21145461 21980433 23098073 23897481 24234451 25348397 27898060 29997244 physical association bioluminescence resonance energy transfer,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct,OmniPath
SOCS3 SOCS2 14525934 16199887 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BMI1 SOCS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RYBP SOCS2 25348397 N/A physical interaction ComPPI
RNF7 SOCS2 25348397 N/A physical interaction ComPPI
PRLR SOCS2 10455112 14525934 25348397 9202403 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTK2B SOCS2 20543098 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SOCS1 SOCS2 25348397 N/A physical interaction ComPPI
KIT SOCS2 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
LCK SOCS2 25348397 N/A physical interaction ComPPI
GHR SOCS2 10585430 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PLA2G1B SOCS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SOCS2 INSR 10453981 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SOCS2 EPOR 11781573 14525934 15644415 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,mammalian protein protein interaction trap,in vitro,two hybrid ComPPI,HPRD,IntAct
SOCS2 PTK2 25348397 N/A physical interaction ComPPI
SOCS2 ELOB 25348397 N/A physical interaction ComPPI
SOCS2 ELOC 16643902 19159283 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SOCS2 CCNC 25348397 N/A physical interaction ComPPI
SOCS2 FLT3 25348397 N/A physical interaction ComPPI
SOCS2 TPD52 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SOCS2 ARFIP2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SOCS2 STK38 25348397 N/A physical interaction ComPPI
SOCS2 IL7R 25348397 N/A physical interaction ComPPI
SOCS2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
IGF1R SOCS2 14525934 25348397 9727029 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SOCS2 SOCS3 16199887 27898060 N/A N/A OmniPath
SOCS3 SOCS2 16199887 27898060 N/A N/A OmniPath
SOCS2 IGF1R 16574995 27898060 9727029 stimulant N/A OmniPath
SOCS2 LEPR 18708154 27898060 inhibition,stimulant N/A OmniPath
SOCS2 GHR 10585430 12135564 16675548 21980433 25505247 27898060 inhibition N/A OmniPath
GHR SOCS2 10585430 12135564 16675548 21980433 25505247 27898060 N/A N/A OmniPath

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