GENE:TGFBRAP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TGFBRAP1 |
| FullNmae | transforming growth factor beta receptor associated protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16836 |
| EnsembleID | ENSG00000135966 |
| Uniprot | Q8WUH2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TGFBRAP1 | lysosomal_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TGFBRAP1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TGFBRAP1 | GO:0005160,GO:0005515,GO:0005737,GO:0005769,GO:0006355,GO:0006886,GO:0006914,GO:0007165,GO:0007179,GO:0008333,GO:0016020,GO:0016020,GO:0033263,GO:0034058,GO:0034058,GO:0034058,GO:0035542,GO:0043231,GO:0046332 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TGFBRAP1 | hsa:9392 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TGFBRAP1 | BMPR1A | 20005715 | interaction type | N/A | PSP |
| TGFBRAP1 | ACVR1B | 20005715 | interaction type | N/A | PSP |
| TGFBRAP1 | TGFBR1 | 20005715 | interaction type | N/A | PSP |
| TGFBRAP1 | ACVRL1 | 20005715 | interaction type | N/A | PSP |
| TGFBRAP1 | TGFBR2 | 20005715 | interaction type | N/A | PSP |
| TGFBRAP1 | ACVR2B | 20005715 | interaction type | N/A | PSP |
| TGFBRAP1 | TGFBR1 | 11278302 18988627 20005715 9545258 | N/A | N/A | SignaLink |
| TGFBRAP1 | TGFBR2 | 11278302 18988627 20005715 | N/A | N/A | SignaLink |
| TGFBRAP1 | ACVR1B | 11278302 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| TGFBRAP1 | ACVR2B | 11278302 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| TGFBRAP1 | ACVRL1 | 11278302 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| TGFBRAP1 | BMPR1A | 11278302 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TGFBRAP1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TGFBRAP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYB | TGFBRAP1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | TGFBRAP1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | TGFBRAP1 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00004B83FE | TGFBRAP1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003003B4 | TGFBRAP1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDAA | TGFBRAP1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018C928 | TGFBRAP1 | 25416803 26682928 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VPS11 | TGFBRAP1 | 24234451 25266290 25348397 26496610 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SMAD4 | TGFBRAP1 | 11278302 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| APPL1 | TGFBRAP1 | 24234451 25266290 25348397 | colocalization | confocal microscopy | ComPPI,IntAct |
| TGFBR2 | TGFBRAP1 | 11278302 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| SMAD2 | TGFBRAP1 | 11278302 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NRBF2 | TGFBRAP1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | TGFBRAP1 | 25348397 | N/A | physical interaction | ComPPI |
| RAB5A | TGFBRAP1 | 24234451 25266290 25348397 | colocalization | confocal microscopy | ComPPI,IntAct |
| EEA1 | TGFBRAP1 | 24234451 25266290 25348397 | colocalization | confocal microscopy | ComPPI,IntAct |
| ALOX5 | TGFBRAP1 | 10051563 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| ACVR1B | TGFBRAP1 | 11278302 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ACVRL1 | TGFBRAP1 | 11278302 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TGFBRAP1 | BMPR1A | 11278302 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TGFBRAP1 | ACVR2B | 11278302 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TGFBRAP1 | UVRAG | 20562859 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TGFBRAP1 | VPS41 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | ACVR1 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | TGFBR1 | 11278302 14525934 25348397 9545258 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| TGFBRAP1 | VPS18 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TGFBRAP1 | VPS16 | 24234451 25266290 25348397 26496610 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TGFBRAP1 | VPS8 | 24234451 25266290 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TGFBRAP1 | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | ISOC2 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | TMEM266 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | ARFGAP1 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | BMT2 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | CROCC | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | RAB5C | 24234451 25266290 25348397 | colocalization,physical association | pull down,confocal microscopy | ComPPI,IntAct |
| TGFBR1 | TGFBRAP1 | 11278302 27898060 9545258 | N/A | N/A | OmniPath |
