Gene Information gene info

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GENE：CACNA1A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CACNA1A
FullNmae calcium voltage-gated channel subunit alpha1 A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1388
EnsembleID ENSG00000141837
Uniprot O00555

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CACNA1A pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CACNA1A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CACNA1A GO:0001540,GO:0005245,GO:0005245,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005886,GO:0005891,GO:0007204,GO:0007268,GO:0008331,GO:0008331,GO:0008331,GO:0016020,GO:0016020,GO:0019905,GO:0034765,GO:0042995,GO:0043025,GO:0043025,GO:0045202,GO:0046872,GO:0050804,GO:0070588,GO:0098703,GO:1904645,GO:1904646,GO:1904646

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CACNA1A hsa:773 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04727 GABAergic synapse - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04730 Long-term depression - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04742 Taste transduction - Homo sapiens (human)
CACNA1A hsa:773 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
CACNA1A hsa:773 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
CACNA1A hsa:773 path:hsa05032 Morphine addiction - Homo sapiens (human)
CACNA1A hsa:773 path:hsa05033 Nicotine addiction - Homo sapiens (human)
CACNA1A hsa:773 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CACNA1A CSNK2B 21078624 23180781 physical association pull down InnateDB
AMIGO2 CACNA1A 21078624 23180781 physical association pull down InnateDB
CACNA1A TUBB2B 21078624 23180781 physical association pull down InnateDB
CACNA1A LAMB1 21078624 23180781 physical association pull down InnateDB
CACNA1A ARHGAP22 21078624 23180781 physical association pull down InnateDB
RBM12B CACNA1A 21078624 23180781 physical association pull down InnateDB
CACNA1A TSPOAP1 21078624 23180781 physical association pull down InnateDB
YLPM1 CACNA1A 21078624 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
AR CACNA1A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CACNA1A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CACNA1A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CACNA1A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CACNA1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 CACNA1A 20371350 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 CACNA1A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 CACNA1A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE CACNA1A 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE CACNA1A 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00000C403E CACNA1A 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00001ADE63 CACNA1A 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 CACNA1A 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS000038446A CACNA1A 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00003804D8 CACNA1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000453664 CACNA1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 CACNA1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 CACNA1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 CACNA1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 CACNA1A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000D0874 CACNA1A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000239117 CACNA1A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000083D87 CACNA1A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00004DA9DB CACNA1A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00001AFC71 CACNA1A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000134ADC CACNA1A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00001B968D CACNA1A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00004B4B85 CACNA1A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000075ABF4 CACNA1A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000045147B CACNA1A 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CACNA1A CACNB1 25361965 interaction type N/A PTMCode2
CACNB1 CACNA1A 25361965 interaction type N/A PTMCode2
CACNA1A CACNB3 25361965 interaction type N/A PTMCode2
CACNB3 CACNA1A 25361965 interaction type N/A PTMCode2
APBA1 CACNA1A 25361965 interaction type N/A PTMCode2
CACNA1A APBA1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SPRY1 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GET3 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EFEMP2 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTGDS CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CALM1 CACNA1A 25348397 N/A two hybrid,physical interaction ComPPI
MOAP1 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EHMT2 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KDM5B CACNA1A 25348397 N/A physical interaction ComPPI
SUMF2 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MATK CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOTCH1 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2L3 CACNA1A 25348397 N/A physical interaction ComPPI
GRN CACNA1A 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
PCSK6 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KALRN CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPM1A CACNA1A 14525934 15728831 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ACTN1 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LRP1 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NELFCD CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SYT1 CACNA1A 14525934 25348397 9303303 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LTBP4 CACNA1A 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
PCSK5 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SRSF1 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ABI1 CACNA1A 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
SCP2 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A CACNB4 10212211 14525934 25348397 9442082 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CACNA1A CABP1 11865310 14525934 14570872 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CACNA1A GNB1 14525934 25348397 9009193 N/A experimental interaction detection,in vitro ComPPI,HPRD
CACNA1A BCL6 16147992 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CACNA1A ABCA2 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A AGRN 21078624 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
CACNA1A ALDOA 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A AMIGO2 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A PCED1B 25348397 N/A physical interaction ComPPI
CACNA1A AP2M1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A ARHGAP22 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A BTG3 25348397 N/A physical interaction ComPPI
CACNA1A TSPOAP1 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A C1QTNF1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A CKAP5 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A CRIM1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A CRMP1 25348397 N/A physical interaction ComPPI
CACNA1A CSNK2B 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A DNAJB5 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A EFEMP1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A EIF3A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A FBLN1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A HHATL 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A HECW1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A HIVEP1 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A HSPG2 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A IP6K1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A JAG2 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A KHDRBS3 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A TELO2 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A KIAA1191 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A SRRM4 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A LAMB1 21078624 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
CACNA1A LLGL1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A ADGRL1 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A LTBP1 25348397 N/A physical interaction ComPPI
CACNA1A LTBP3 25348397 N/A physical interaction ComPPI
CACNA1A MATN2 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A MEGF6 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A MEGF8 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A CYSRT1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A MIA3 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A NDUFB8 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A NELL1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A NELL2 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A NOXA1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A OLIG1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A PPIG 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A PPP1R12C 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A RBM12B 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A RIMBP2 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A RPL31 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A RPS17 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A PUF60 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A TAF15 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A TSC22D1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A TSPAN7 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A TUBB2B 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A UQCRC2 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A VARS1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A VPS52 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A VWF 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A WBP1 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A YLPM1 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CACNA1A ZCCHC17 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A ZNF233 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNA1A GNB2 25348397 N/A physical interaction ComPPI
CACNA1A KLHL1 25348397 N/A physical interaction ComPPI
CACNA1A TCTN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CACNA1A TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CACNA1A MAP1B 25348397 N/A physical interaction ComPPI
CACNA1A GOLGA6L9 21078624 24234451 25348397 physical association two hybrid ComPPI,IntAct
PMM1 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MANBAL CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CACNB1 CACNA1A 1370480 14525934 N/A experimental interaction detection HPRD
CALM2 CACNA1A 21078624 24234451 physical association two hybrid IntAct
PRKACA CACNA1A 12410316 27898060 inhibition N/A OmniPath
CACNA1A CSNK2B 21078624 27898060 N/A N/A OmniPath
CACNA1A ARHGAP22 21078624 27898060 N/A N/A OmniPath
CACNA1A AMIGO2 21078624 27898060 N/A N/A OmniPath
CACNA1A TSPOAP1 21078624 27898060 N/A N/A OmniPath
CACNA1A YLPM1 21078624 27898060 N/A N/A OmniPath
CACNA1A RBM12B 21078624 27898060 N/A N/A OmniPath
CACNA1A LAMB1 21078624 27898060 N/A N/A OmniPath
CACNA1A TUBB2B 21078624 27898060 N/A N/A OmniPath

Visualization










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