GENE：FER
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FER |
| FullNmae | FER tyrosine kinase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3655 |
| EnsembleID | ENSG00000151422 |
| Uniprot | P16591 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FER | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FER | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| FER | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| FER | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FER | GO:0000226,GO:0000785,GO:0001932,GO:0004713,GO:0004715,GO:0005154,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0005912,GO:0005938,GO:0006468,GO:0006468,GO:0006935,GO:0007155,GO:0007260,GO:0007281,GO:0008157,GO:0008284,GO:0008284,GO:0008286,GO:0008286,GO:0008289,GO:0009898,GO:0010591,GO:0010762,GO:0015629,GO:0015630,GO:0018108,GO:0019221,GO:0030027,GO:0030036,GO:0030054,GO:0030335,GO:0030838,GO:0032496,GO:0033007,GO:0034333,GO:0034446,GO:0034614,GO:0035426,GO:0035556,GO:0036006,GO:0036119,GO:0038095,GO:0038095,GO:0038109,GO:0042058,GO:0043304,GO:0044331,GO:0046777,GO:0048008,GO:0048008,GO:0050904,GO:0051092,GO:0060009,GO:0070102,GO:0072520,GO:0120179 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FER | hsa:2241 | path:hsa04520 | Adherens junction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PDGFRB | FER | 23589302 | phosphorylation reaction,stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | FER | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | FER | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | FER | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | FER | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000015D23B | FER | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002075FA | FER | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003E6EFA | FER | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | FER | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | FER | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075994C | FER | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E6F45 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FF522 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C4762 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001270D3 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CBE63 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000E7139 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000555DA6 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CEB74 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B0E50 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | FER | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRC | FER | 22135298 | phosphorylation | N/A | PhosphoSite |
| FER | EZR | 22135298 | phosphorylation | N/A | PhosphoSite |
| FER | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
| FER | AR | 22135298 | phosphorylation | N/A | PhosphoSite |
| FER | NSF | 22135298 | phosphorylation | N/A | PhosphoSite |
| FER | STAT3 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| FER | FER | 22135298 | phosphorylation | N/A | PhosphoSite |
| FER | JUP | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| FER | GAB1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| STAT3 | FER | 25361965 | interaction type | N/A | PTMCode2 |
| FER | CTTN | 25361965 | interaction type | N/A | PTMCode2 |
| CTTN | FER | 25361965 | interaction type | N/A | PTMCode2 |
| JUP | FER | 25361965 | interaction type | N/A | PTMCode2 |
| FER | JAK1 | 25361965 | interaction type | N/A | PTMCode2 |
| JAK1 | FER | 25361965 | interaction type | N/A | PTMCode2 |
| FER | CTNNB1 | 25361965 | interaction type | N/A | PTMCode2 |
| CTNNB1 | FER | 25361965 | interaction type | N/A | PTMCode2 |
| FER | TMF1 | 25361965 | interaction type | N/A | PTMCode2 |
| TMF1 | FER | 25361965 | interaction type | N/A | PTMCode2 |
| FER | CTNND1 | 25361965 | interaction type | N/A | PTMCode2 |
| CTNND1 | FER | 25361965 | interaction type | N/A | PTMCode2 |
| CDH1 | FER | 25361965 | interaction type | N/A | PTMCode2 |
| FER | CDH1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HSP90AB1 | FER | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| CRK | FER | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CTNND1 | FER | 12640114 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ERBB2 | FER | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| PIK3R1 | FER | 25348397 | N/A | physical interaction | ComPPI |
| JUP | FER | 14517306 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| YWHAB | FER | 14525934 15324660 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PIK3R3 | FER | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| HSP90AA1 | FER | 25348397 | N/A | physical interaction | ComPPI |
| CDH1 | FER | 25348397 | N/A | physical interaction | ComPPI |
| JAK1 | FER | 12738762 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| DNM1 | FER | 25348397 | N/A | physical interaction | ComPPI |
| FER | TMF1 | 14525934 25348397 9742951 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| FER | CTNNB1 | 12640114 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| FER | STAT3 | 10878010 12738762 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| FER | IRS1 | 11006284 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| FER | EGFR | 14525934 25348397 7623846 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| FER | CTTN | 10921917 14525934 25348397 9722593 9748248 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| FER | DNM2 | 25348397 | N/A | physical interaction | ComPPI |
| FER | DNM3 | 25348397 | N/A | physical interaction | ComPPI |
| FER | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| FER | ERBB3 | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| FER | CDC37 | 24234451 25036637 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| FER | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| FER | PPP1R7 | 25348397 | N/A | physical interaction | ComPPI |
| FER | LIMA1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FER | ARC | 25348397 | N/A | physical interaction | ComPPI |
| FER | ABI1 | 20598684 24234451 25348397 | N/A | array technology | ComPPI,IntAct |
| FER | CBX4 | 25348397 | N/A | tandem affinity purification | ComPPI |
| FER | NSF | 15322554 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
| FER | FYB1 | 22074159 24234451 25348397 | association | pull down | ComPPI,IntAct |
| PKM | FER | 25348397 | N/A | protein kinase assay | ComPPI |
| KCTD4 | FER | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,validated two hybrid | ComPPI,IntAct |
| SGG | FER | 25348397 | N/A | pull down | ComPPI |
| FER | FER | 10998246 14525934 17192257 | N/A | experimental interaction detection | HPRD |
| FER | CALM2 | 10411641 14525934 3350007 3472906 | N/A | experimental interaction detection | HPRD |
| H2BC21 | FER | 24234451 30021884 | physical association | cross-linking study | IntAct |
| FER | CTNNB1 | 12640114 27898060 | inhibition,stimulant | N/A | OmniPath |
| FER | CTTN | 10921917 16497976 17016520 17287340 17389395 18088087 18491316 18669648 18707149 19413330 20068231 27898060 9722593 9748248 | stimulant | N/A | OmniPath |
| FER | EZR | 10377409 1382070 15197272 15623525 16873375 22014578 24385580 25867068 26010871 27898060 9230083 | N/A | N/A | OmniPath |
| FER | AR | 23906537 27898060 | stimulant | N/A | OmniPath |
| FER | STAT3 | 10878010 12738762 12763138 15592455 15951569 16568091 17389395 18083107 18234692 19534553 27898060 7701321 | stimulant | N/A | OmniPath |
| PDGFRA | FER | 10998246 27898060 | N/A | N/A | OmniPath |
| FER | PECAM1 | 15592455 18083107 18088087 19342684 19690332 27898060 9298995 | N/A | N/A | OmniPath |