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GENE：CYP27A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CYP27A1
FullNmae cytochrome P450 family 27 subfamily A member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2605
EnsembleID ENSG00000135929
Uniprot Q02318

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CYP27A1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CYP27A1 GO:0005506,GO:0005739,GO:0005743,GO:0005759,GO:0006699,GO:0006699,GO:0006699,GO:0006707,GO:0006707,GO:0008203,GO:0008395,GO:0016125,GO:0020037,GO:0030343,GO:0030343,GO:0031073,GO:0031073,GO:0036378,GO:0036378,GO:0047103,GO:0047748,GO:0047749

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CYP27A1 hsa:1593 path:hsa00120 Primary bile acid biosynthesis - Homo sapiens (human)
CYP27A1 hsa:1593 path:hsa01100 Metabolic pathways - Homo sapiens (human)
CYP27A1 hsa:1593 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)
CYP27A1 hsa:1593 path:hsa04979 Cholesterol metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR CYP27A1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
GATA3 CYP27A1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 CYP27A1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CYP27A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CYP27A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CYP27A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CYP27A1 12957378 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CYP27A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NR0B2 CYP27A1 15581596 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CYP27A1 11867220 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CYP27A1 11867220 trascriptional regulation,stimulation inferred by curator TFlink
SP3 CYP27A1 11867220 trascriptional regulation,stimulation inferred by curator TFlink
PPARG CYP27A1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PRDX4 CYP27A1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UQCRC2 CYP27A1 25348397 N/A physical interaction ComPPI
PC CYP27A1 25348397 N/A physical interaction ComPPI
FASN CYP27A1 25348397 N/A physical interaction ComPPI
CCT3 CYP27A1 25348397 N/A physical interaction ComPPI

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