Gene Information gene info

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GENE：RYR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RYR1
FullNmae ryanodine receptor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10483
EnsembleID ENSG00000196218
Uniprot P21817

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RYR1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RYR1 GO:0001666,GO:0003151,GO:0005219,GO:0005219,GO:0005219,GO:0005219,GO:0005219,GO:0005245,GO:0005262,GO:0005509,GO:0005516,GO:0005524,GO:0005737,GO:0005790,GO:0005886,GO:0005938,GO:0006816,GO:0006936,GO:0006941,GO:0014701,GO:0014802,GO:0014808,GO:0014808,GO:0015278,GO:0016529,GO:0030018,GO:0031000,GO:0031090,GO:0031674,GO:0033017,GO:0033017,GO:0033017,GO:0033017,GO:0034704,GO:0042383,GO:0043588,GO:0043931,GO:0048741,GO:0048763,GO:0048763,GO:0051209,GO:0051209,GO:0051289,GO:0051480,GO:0070062,GO:0071277,GO:0071313,GO:0071313,GO:1990425

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RYR1 hsa:6261 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
RYR1 hsa:6261 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
RYR1 hsa:6261 path:hsa04713 Circadian entrainment - Homo sapiens (human)
RYR1 hsa:6261 path:hsa04730 Long-term depression - Homo sapiens (human)
RYR1 hsa:6261 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
RYR1 hsa:6261 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
RYR1 hsa:6261 path:hsa05020 Prion disease - Homo sapiens (human)
RYR1 hsa:6261 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PLCG1 RYR1 17474147 23180781 physical association peptide array InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 RYR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RYR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RYR1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RYR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RYR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RYR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RYR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RYR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RYR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 RYR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RYR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
RYR1 CACNA1S 25361965 interaction type N/A PTMCode2
CACNA1S RYR1 25361965 interaction type N/A PTMCode2
CAMK2B RYR1 25361965 interaction type N/A PTMCode2
RYR1 CAMK2B 25361965 interaction type N/A PTMCode2
HOMER1 RYR1 25361965 interaction type N/A PTMCode2
RYR1 HOMER1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
S100A1 RYR1 14525934 25348397 27898060 9298970 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CALM1 RYR1 25348397 N/A physical interaction ComPPI
FKBP1A RYR1 11171121 11237759 11279144 12704193 14525934 18268335 24234451 25348397 27898060 8521476 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
NCK1 RYR1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 RYR1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
PRKACA RYR1 14525934 14532276 25348397 8380342 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKG1 RYR1 14525934 14532276 25348397 8380342 N/A experimental interaction detection,in vitro ComPPI,HPRD
TTN RYR1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RYR2 RYR1 12213830 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PPP1CA RYR1 18755143 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
RYR1 CAMK2G 25348397 N/A in vitro ComPPI
RYR1 TRDN 10212196 10531621 11069905 14525934 14638677 25348397 27898060 7721813 9287354 9890886 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
RYR1 HOMER2 12223488 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RYR1 HOMER3 12223488 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RYR1 HOMER1 12223488 12810060 14525934 14660561 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
RYR1 ANK1 25348397 N/A physical interaction ComPPI
RYR1 TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RYR1 PLCG1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
RYR1 PPP2CA 18755143 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
RYR1 MYOM2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
RYR1 PDLIM3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RYR1 TULP3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RYR1 PDE4D 25348397 N/A anti bait coimmunoprecipitation ComPPI
CACNA1S RYR1 12496092 14525934 25348397 9199552 N/A experimental interaction detection,in vivo ComPPI,HPRD
RYR1 CALM2 12509414 14525934 N/A experimental interaction detection HPRD
RYR1 RYR1 12509414 14525934 N/A experimental interaction detection HPRD
METTL3 RYR1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
PPP1CB RYR1 27898060 9922179 N/A N/A OmniPath
PPP1CA RYR1 18755143 27898060 9922179 N/A N/A OmniPath
CAMK2A RYR1 1645727 27898060 stimulant N/A OmniPath
SRI RYR1 27898060 7592856 9312152 inhibition N/A OmniPath
PPP1CC RYR1 27898060 9922179 N/A N/A OmniPath
HOMER2 RYR1 12223488 27898060 stimulant N/A OmniPath

Visualization










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