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GENE：ELOC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ELOC
FullNmae elongin C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11617
EnsembleID ENSG00000154582
Uniprot Q15369

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ELOC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ELOC GO:0001222,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006367,GO:0006511,GO:0016567,GO:0016567,GO:0030674,GO:0031462,GO:0031466,GO:0070449,GO:0070449,GO:0140958

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ELOC hsa:6921 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
ELOC hsa:6921 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
ELOC hsa:6921 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
ELOC hsa:6921 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ELOC hsa:6921 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SOCS4 ELOC 17997974 23180781 physical association x-ray crystallography InnateDB
ELOC SOCS3 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELOC SPSB1 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPSB2 ELOC 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAB40C ELOC 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELOC WSB1 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELOC LRRC41 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
VHL ELOC 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
LRR1 ELOC 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
FEM1B ELOC 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
SOCS5 ELOC 15590694 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD9 ELOC 17936701 23180781 physical association gst pull down InnateDB
ELOC ASB3 15899873 23180781 physical association anti tag coimmunoprecipitation InnateDB
KMT2A ELOC 22174154 23180781 physical association anti tag coimmunoprecipitation InnateDB
NEDD8 ELOC 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB
CUL5 ELOC 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB
CUL3 ELOC 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ELOC 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ELOC 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA ELOC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ELOC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ELOC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ELOC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ELOC 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003CCBB9 ELOC 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000171525 ELOC 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000012A1DD ELOC 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000055BBE5 ELOC 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001AFC71 ELOC 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000028BB8 ELOC 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000022B729 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000292B1 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA ELOC 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SPSB3 ELOC 25348397 N/A physical interaction ComPPI
CUL5 ELOC 25348397 N/A pull down,physical interaction,physical interaction ComPPI
SOCS3 ELOC 10051596 14525934 15601820 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
EIF1B ELOC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RBM3 ELOC 25348397 N/A physical interaction ComPPI
TRAF6 ELOC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DCUN1D1 ELOC 25348397 N/A physical interaction ComPPI
LAGE3 ELOC 25348397 N/A physical interaction ComPPI
MED8 ELOC 12149480 14525934 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
DPPA4 ELOC 25348397 N/A physical interaction ComPPI
RACK1 ELOC 25348397 N/A physical interaction ComPPI
APPBP2 ELOC 25348397 N/A physical interaction ComPPI
RNF7 ELOC 25348397 N/A physical interaction ComPPI
SERTAD1 ELOC 25348397 N/A physical interaction ComPPI
SOCS1 ELOC 10051596 14525934 15304214 15601820 16643902 17183367 19385048 21119685 22787435 24234451 25348397 27898060 9869640 physical association two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid array,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
NOTCH4 ELOC 25348397 N/A physical interaction ComPPI
HIF1A ELOC 12004076 12050673 17353276 24234451 25348397 physical association filter binding,surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,surface plasmon resonance array ComPPI,IntAct
MYBBP1A ELOC 25348397 N/A physical interaction ComPPI
COPS5 ELOC 25348397 N/A physical interaction ComPPI
ARHGAP1 ELOC 25348397 N/A physical interaction ComPPI
RBX1 ELOC 12149480 24234451 25348397 association coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL3 ELOC 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GHR ELOC 25348397 N/A physical interaction ComPPI
MRAS ELOC 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBC ELOC 25348397 N/A physical interaction ComPPI
ILK ELOC 25348397 N/A physical interaction ComPPI
CISH ELOC 25348397 N/A physical interaction ComPPI
SOCS2 ELOC 16643902 19159283 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CFTR ELOC 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ARID1B ELOC 25348397 N/A physical interaction ComPPI
SQSTM1 ELOC 25348397 N/A physical interaction ComPPI
CTR9 ELOC 25348397 N/A physical interaction ComPPI
ECT2 ELOC 25348397 N/A physical interaction ComPPI
ABCE1 ELOC 25348397 N/A physical interaction ComPPI
ASB2 ELOC 25348397 N/A physical interaction ComPPI
NEDD8 ELOC 25348397 N/A physical interaction ComPPI
CUL2 ELOC 14525934 15601820 17183367 19327355 23563313 24234451 25348397 9447969 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SPR ELOC 25348397 N/A physical interaction ComPPI
ID3 ELOC 25348397 N/A physical interaction ComPPI
ADRB2 ELOC 25348397 N/A physical interaction ComPPI
CBX5 ELOC 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPOR ELOC 25348397 N/A physical interaction ComPPI
VHL ELOC 14525934 15601820 17353931 18305400 18323857 20871634 24234451 25348397 7660122 7660130 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PINX1 ELOC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SKP2 ELOC 25348397 N/A physical interaction ComPPI
NOS2 ELOC 25348397 N/A physical interaction ComPPI
COPS3 ELOC 25348397 N/A physical interaction ComPPI
COPS4 ELOC 25348397 N/A physical interaction ComPPI
COPS6 ELOC 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB ELOC 10205047 10587522 12004076 12050673 12149480 14525934 16189514 21516116 24234451 25348397 25416956 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
ELOC SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELOC LRRC41 11384984 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELOC ELOA3P 11994304 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELOC USP33 11739384 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ELOC EXT2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC ASB8 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ELOC ELOA 25348397 N/A physical interaction ComPPI
ELOC PAN2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC TCEAL1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC COMMD1 17183367 23563313 24234451 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
ELOC DIO2 25348397 N/A physical interaction ComPPI
ELOC ASB3 25348397 N/A physical interaction ComPPI
ELOC ASB9 25348397 N/A physical interaction ComPPI
ELOC MCM7 25348397 N/A physical interaction ComPPI
ELOC SPSB1 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC SPSB2 15601820 19159283 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC SPSB4 15601820 19159283 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC CORO7 21130766 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC UBXN7 18775313 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC FAF2 18775313 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC FEM1B 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC PCK1 25348397 N/A physical interaction ComPPI
ELOC PRAME 21822215 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ELOC RAB40B 25348397 N/A physical interaction ComPPI
ELOC ASB1 25348397 N/A physical interaction ComPPI
ELOC ASB6 25348397 N/A physical interaction ComPPI
ELOC WSB1 25348397 N/A physical interaction ComPPI
ELOC TOP2A 25348397 N/A physical interaction ComPPI
ELOC ZYG11B 14525934 17304241 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ELOC ZER1 17304241 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ELOC PCMTD2 25348397 N/A physical interaction ComPPI
ELOC KLHDC2 25348397 N/A physical interaction ComPPI
ELOC KLHDC3 25348397 N/A physical interaction ComPPI
ELOC KMT2A 25348397 N/A physical interaction ComPPI
ELOC OSGEP 25348397 N/A physical interaction ComPPI
ELOC LRR1 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC LRRC14 25348397 N/A physical interaction ComPPI
ELOC RAB40C 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC JTB 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELOC RCAN2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELOC WNT7B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELOC CENPC 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELOC CYP2J2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELOC EFNB3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELOC CPTP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELOC APEX1 25348397 N/A physical interaction ComPPI
ELOC ASB7 25348397 N/A physical interaction ComPPI
ELOC ASB10 25348397 N/A physical interaction ComPPI
ELOC ASB12 25348397 N/A physical interaction ComPPI
ELOC MTMR8 25348397 N/A physical interaction ComPPI
ELOC ASB13 25348397 N/A physical interaction ComPPI
ELOC ASB14 25348397 N/A physical interaction ComPPI
ELOC ASB15 25348397 N/A physical interaction ComPPI
ELOC ASB16 25348397 N/A physical interaction ComPPI
ELOC POP1 25348397 N/A physical interaction ComPPI
ELOC SOCS4 16643902 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ELOC FUS 25348397 N/A physical interaction ComPPI
ELOC CBFB 25348397 N/A pull down,physical interaction,physical interaction ComPPI
ELOC RAB40A 25348397 N/A physical interaction ComPPI
ELOC RAB40AL 25348397 N/A physical interaction ComPPI
ELOC TSC22D4 25348397 N/A physical interaction ComPPI
ELOC XPNPEP1 25348397 N/A physical interaction ComPPI
ELOC IFI16 25348397 N/A physical interaction ComPPI
ELOC MYH6 25348397 N/A physical interaction ComPPI
ELOC FBXO7 25348397 N/A physical interaction ComPPI
ELOC CTDSPL2 25348397 N/A physical interaction ComPPI
ELOC CHMP4B 25348397 N/A physical interaction ComPPI
ELOC SGO1 25348397 N/A physical interaction ComPPI
ELOC ID2 25348397 N/A physical interaction ComPPI
ELOC ID1 25348397 N/A physical interaction ComPPI
ELOC OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOC PCGF1 25348397 N/A physical interaction ComPPI
ELOC BCOR 25348397 N/A physical interaction ComPPI
ELOC NANOGP8 25348397 N/A physical interaction ComPPI
ELOC NANOG 25348397 N/A physical interaction ComPPI
ELOC POU5F1 25348397 N/A physical interaction ComPPI
ELOC LNX1 25348397 N/A physical interaction ComPPI
ELOC SOCS5 16643902 24234451 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ELOC TSC22D1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELOC PPRC1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELOC SNRPN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELOC EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELOC PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ELOC EPOP 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
ELOC HIF1AN 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
ELOC BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
ELOA2 ELOC 10692460 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NRBP1 ELOC 25348397 N/A physical interaction ComPPI
SAT2 ELOC 25348397 N/A physical interaction ComPPI
ARIH2 ELOC 24076655 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
METTL21C ELOC 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HIF-1 ELOC 12050673 24234451 physical association surface plasmon resonance IntAct
METTL3 ELOC 24234451 29507755 association anti tag coimmunoprecipitation IntAct
METTL14 ELOC 24234451 29507755 association anti tag coimmunoprecipitation IntAct
TANK ELOC 24234451 30561431 association virotrap IntAct
SOCS3 ELOC 10051596 12783885 15601820 17135358 18590740 19385048 22084247 27898060 9869640 N/A N/A OmniPath
ELOC H1-1 20551309 27898060 stimulant N/A OmniPath
SOCS5 ELOC 15590694 16643902 19385048 27898060 N/A N/A OmniPath
ELOC NOTCH4 22001063 27898060 inhibition N/A OmniPath
SOCS4 ELOC 16643902 17997974 19385048 27898060 N/A N/A OmniPath

Visualization










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